Retrospective analysis of Vogt-Koyanagi-Harada’s recurrence within a case series of nineteen patients followed between 2003 and 2018 in an academic center

Retrospective analysis of Vogt-Koyanagi-Harada’s recurrence within a case series of nineteen patients followed between 2003 and 2018 in an academic center | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Retrospective analysis of Vogt-Koyanagi-Harada’s recurrence within a case series of nineteen patients followed between 2003 and 2018 in an academic center Alexandra Kozyreff, Alice Bughin, Chantal Lefebvre, Lucie Pothen, and 1 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-4638541/v1 This work is licensed under a CC BY 4.0 License Status: Published Journal Publication published 01 Jul, 2025 Read the published version in Journal of Ophthalmic Inflammation and Infection → Version 1 posted 9 You are reading this latest preprint version Abstract Purpose: to define a timeframe of recurrences according to the clinical presentation of the inflammation and to the course of the disease. This could influence the final visual acuity and avoid ocular complication such as cataract, glaucoma, choroidal neovascularization, subretinal fibrosis or fundus depigmentation. Material and methods: retrospective study of nineteen patients affected of Vogt-Koyanagi-Harada disease followed between 2003 and 2018. Results: within our case series, 53% of our patients had no recurrence during a follow-up up to one hundred and sixty-eight months. Among the nine patients presenting a recurrence, five had at least one episode of posterior inflammation, one exhibited anterior and posterior recurrence, and five developed at least one recurrence in anterior structures. According to the Kaplan Meier’s method, the overall survival without any recurrence at three months is equal to 68% ± 11%. All posterior segment inflammatory relapses occurred within three months and a half of initiation of systemic treatment. On the other hand, the timeline of anterior recurrence is more scattered. They appeared between two and thirty-seven months. This careful follow-up distinguishing the type of inflammatory recurrence made it possible to find final visual acuity greater than or equal to 9/10 (equivalent ≥ 20/25), with the exception of one amblyopic eye. Conclusion: The chronological occurrence of inflammatory episodes is earlier posteriorly than anteriorly. A posterior recurrence does not expose to a higher risk of anterior inflammation relapse during the follow-up. This distinction is important for understanding understandig the course of the disease. In fact, the differentiation between the initial acute phase (mainly posterior inflammation) and chronic recurrences (granulomatous anterior segment inflammation) allows better adaptation of systemic therapy and better visual prognosis in the long term. Vogt-Koyanagi-Harada disease granulomatous choroiditis recurrence acute initial phase chronic recurrent phase treatment survival curve Full Text Additional Declarations No competing interests reported. Cite Share Download PDF Status: Published Journal Publication published 01 Jul, 2025 Read the published version in Journal of Ophthalmic Inflammation and Infection → Version 1 posted Editorial decision: Revision requested 26 Aug, 2024 Reviews received at journal 21 Aug, 2024 Reviews received at journal 20 Aug, 2024 Reviewers agreed at journal 16 Aug, 2024 Reviewers agreed at journal 11 Aug, 2024 Reviewers invited by journal 09 Aug, 2024 Editor assigned by journal 27 Jul, 2024 Submission checks completed at journal 01 Jul, 2024 First submitted to journal 25 Jun, 2024 You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-4638541","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":321454101,"identity":"2d09a9af-8958-4bd5-a665-41e6b9891d19","order_by":0,"name":"Alexandra 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This could influence the final visual acuity and avoid ocular complication such as cataract, glaucoma, choroidal neovascularization, subretinal fibrosis or fundus depigmentation.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eMaterial and methods:\u003c/strong\u003e retrospective study of nineteen patients affected of Vogt-Koyanagi-Harada disease followed between 2003 and 2018.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eResults:\u003c/strong\u003e within our case series, 53% of our patients had no recurrence during a follow-up up to one hundred and sixty-eight months. Among the nine patients presenting a recurrence, five had at least one episode of posterior inflammation, one exhibited anterior and posterior recurrence, and five developed at least one recurrence in anterior structures.\u003c/p\u003e\n\u003cp\u003eAccording to the Kaplan Meier’s method, the overall survival without any recurrence at three months is equal to 68% ± 11%. All posterior segment inflammatory relapses occurred within three months and a half of initiation of systemic treatment. On the other hand, the timeline of anterior recurrence is more scattered. They appeared between two and thirty-seven months.\u003c/p\u003e\n\u003cp\u003eThis careful \u0026nbsp;follow-up distinguishing the type of inflammatory recurrence made it possible \u0026nbsp;to find final visual acuity greater than or equal to 9/10 (equivalent ≥ \u0026nbsp;20/25), with the exception of one amblyopic eye.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eConclusion:\u003c/strong\u003e The chronological occurrence of inflammatory episodes is earlier posteriorly than anteriorly. A posterior recurrence does not expose to a higher risk of anterior inflammation relapse during the follow-up. This distinction is important for understanding understandig the course of the disease. 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