Real world use of Tixagevimab/Cilgavimab pre-exposure prophylaxis of COVID-19 in immunocompromised individuals: data from the OCTOPUS study.

Real world use of Tixagevimab/Cilgavimab pre-exposure prophylaxis of COVID-19 in immunocompromised individuals: data from the OCTOPUS study. | Authorea try { document.documentElement.classList.add('js'); } catch (e) { } var _gaq = _gaq || []; _gaq.push(['_setAccount', 'G-8VDV14Y67G']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 'https://ssl' : 'http://www') + '.google-analytics.com/ga.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s); })(); Skip to main content Preprints Collections Wiley Open Research IET Open Research Ecological Society of Japan All Collections About About Authorea FAQs Contact Us Quick Search anywhere Search for preprint articles, keywords, etc. Search Search ADVANCED SEARCH SCROLL This is a preprint and has not been peer reviewed. Data may be preliminary. 9 March 2024 V1 Latest version Share on Real world use of Tixagevimab/Cilgavimab pre-exposure prophylaxis of COVID-19 in immunocompromised individuals: data from the OCTOPUS study. Authors : Alessandra Vergori 0000-0001-6944-0686 [email protected] , Giulia Matusali , Eleonora Cimini , Licia Bordi 0000-0003-3962-3646 , Paola Borrelli , Simone Lanini , Roberta Palazzi , … Show All … , Jessica Paulicelli , Davide Mariotti , Valentina Mazzotta 0000-0002-0240-7504 , Stefania Notari , R. Casetti , Massimo Francalancia , Silvia Rosati , Alessandra D’Abramo , Cosmina Mija , Paola Mencarini , Eugenia Milozzi , Caraffa E , Simona Sica , Elisabetta Metafuni , Federica Sorà , Angela Rago , Agostina Siniscalchi , Elisabetta Abruzzese , Mariagrazia Garzia , Giovanni Luzi , Roberta Battistini , Luca Prosperini , Antonella Cingolani , Enrico Girardi , Fabrizio Maggi , and Andrea Antinori Show Fewer Authors Info & Affiliations https://doi.org/10.22541/au.171000716.67591832/v1 Published Vaccines Version of record Peer review timeline 511 views 73 downloads Contents Abstract Supplementary Material Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract We report real world use over time in immunocompromised subjects receiving tixagevimab/cilgavimab (T/C) pre-exposure prophylaxis (PrEP). Observational study on participants receiving T/C PrEP stratified: never had COVID-19 (NoC), hybrids (H) and breakthrough infections (BTIs) if COVID-19 before or after PrEP, respectively. Anti-RBD IgG and BA.5 neutralizing antibodies (nAbs), mucosal IgG, T-cell immunity at the administration of T/C (T0), 3 (T1), 6 (T2), and 9 (T3) months after, were measured. Comparison of markers in each group across timepoints, Poisson regression model for BTIs incidence rate ratios were performed. N=231 participants: median age 63 years (IQR 54.0-73.0), 84% hematological disease, median vaccine dose of three. N=72 NoC, 103 H and 56 (24%) BTIs, mostly mild/moderate, IR 4.2 (95%CI 3.2-5.4) BTIs/100 patients-months, no factors associated with. A significant increase of anti-RBD IgG at T1 was observed in all the groups, with a decline at T2. GMTs of anti-BA.5 nAbs were low at T1 for all the groups and around/below the cut off. No changes of IFN-γ. Overall, a mucosal response was observed at T1. An incidence of 24% of mild/moderate BTIs was observed. Anti-RBD IgG levels persistence was ensured, BA.5 nAbs were low/undetectable, cellular T immunity remained stable. Supplementary Material File (vergori et al_octopus study_final.docx) Download 451.55 KB Information & Authors Information Version history V1 Version 1 09 March 2024 Peer review timeline Published Vaccines Version of Record 17 Jul 2024 Published Copyright This work is licensed under a Non Exclusive No Reuse License. Keywords cell-mediated immunity covid-19 disease control humoral immunity immune responses passive prophylaxis sars coronavirus virus classification Authors Affiliations Alessandra Vergori 0000-0001-6944-0686 [email protected] Istituto Nazionale Malattie Infettive Lazzaro Spallanzani View all articles by this author Giulia Matusali Istituto Nazionale Malattie Infettive Lazzaro Spallanzani View all articles by this author Eleonora Cimini Istituto Nazionale Malattie Infettive Lazzaro Spallanzani View all articles by this author Licia Bordi 0000-0003-3962-3646 Istituto Nazionale Malattie Infettive Lazzaro Spallanzani View all articles by this author Paola Borrelli Universita degli Studi Gabriele d'Annunzio Chieti Pescara Dipartimento di Scienze Mediche Orali e Biotecnologiche View all articles by this author Simone Lanini Istituto Nazionale Malattie Infettive Lazzaro Spallanzani View all articles by this author Roberta Palazzi Istituto Nazionale Malattie Infettive Lazzaro Spallanzani View all articles by this author Jessica Paulicelli Istituto Nazionale Malattie Infettive Lazzaro Spallanzani View all articles by this author Davide Mariotti Istituto Nazionale Malattie Infettive Lazzaro Spallanzani View all articles by this author Valentina Mazzotta 0000-0002-0240-7504 Istituto Nazionale Malattie Infettive Lazzaro Spallanzani View all articles by this author Stefania Notari Istituto Nazionale Malattie Infettive Lazzaro Spallanzani View all articles by this author R. Casetti Istituto Nazionale Malattie Infettive Lazzaro Spallanzani View all articles by this author Massimo Francalancia Istituto Nazionale Malattie Infettive Lazzaro Spallanzani View all articles by this author Silvia Rosati Istituto Nazionale Malattie Infettive Lazzaro Spallanzani View all articles by this author Alessandra D’Abramo Istituto Nazionale Malattie Infettive Lazzaro Spallanzani View all articles by this author Cosmina Mija Istituto Nazionale Malattie Infettive Lazzaro Spallanzani View all articles by this author Paola Mencarini Istituto Nazionale Malattie Infettive Lazzaro Spallanzani View all articles by this author Eugenia Milozzi Istituto Nazionale Malattie Infettive Lazzaro Spallanzani View all articles by this author Caraffa E Istituto Nazionale Malattie Infettive Lazzaro Spallanzani View all articles by this author Simona Sica Fondazione Policlinico Universitario Agostino Gemelli IRCCS View all articles by this author Elisabetta Metafuni Fondazione Policlinico Universitario Agostino Gemelli IRCCS View all articles by this author Federica Sorà Fondazione Policlinico Universitario Agostino Gemelli IRCCS View all articles by this author Angela Rago Presidio Ospedaliero San Filippo Neri View all articles by this author Agostina Siniscalchi Presidio Ospedaliero San Filippo Neri View all articles by this author Elisabetta Abruzzese Ospedale Sant'Eugenio View all articles by this author Mariagrazia Garzia Azienda Ospedaliera San Camillo Forlanini View all articles by this author Giovanni Luzi Azienda Ospedaliera San Camillo Forlanini View all articles by this author Roberta Battistini Azienda Ospedaliera San Camillo Forlanini View all articles by this author Luca Prosperini Azienda Ospedaliera San Camillo Forlanini View all articles by this author Antonella Cingolani Fondazione Policlinico Universitario Agostino Gemelli IRCCS View all articles by this author Enrico Girardi Istituto Nazionale Malattie Infettive Lazzaro Spallanzani View all articles by this author Fabrizio Maggi Istituto Nazionale Malattie Infettive Lazzaro Spallanzani View all articles by this author Andrea Antinori Istituto Nazionale Malattie Infettive Lazzaro Spallanzani View all articles by this author Metrics & Citations Metrics Article Usage 511 views 73 downloads .FvxKWukQNSOunydq8rnd { width: 100px; } Citations Download citation Alessandra Vergori, Giulia Matusali, Eleonora Cimini, et al. Real world use of Tixagevimab/Cilgavimab pre-exposure prophylaxis of COVID-19 in immunocompromised individuals: data from the OCTOPUS study.. Authorea . 09 March 2024. DOI: https://doi.org/10.22541/au.171000716.67591832/v1 If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download. For more information or tips please see 'Downloading to a citation manager' in the Help menu . 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