POOR SLEEP QUALITY, CHRONIC PAIN, AND MELATONIN

Lenita Mayumi Suzuki, Daniel Tsutomu Suzuki, Viviane Canhizares Evangelista Araujo, Eduardo Vinicius Barboza dos Santos, Gabriela Henrica Abu Kamel Gazetta, Adriana Porto Nunes Gazetta, Marcia Abusio Cardin, Leila Maria Guissoni Campos
2025 · doi:10.56238/arev7n2-169 · W7077062806
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Abstract

Objective: Considering that inflammatory responses affect the nocturnal peak of melatonin and that sleep interruption activates inflammatory mechanisms that trigger changes in the effector systems that regulate the immune system, increasing the inflammatory response and pain, this study investigates the efficacy of melatonin as a treatment for the symptoms of the poor sleep quality and pain in the endometriosis. Methods: Endometriosis was diagnosed by medical history and imaging tests (ultrasound or magnetic resonance imaging). Pain intensity was assessed using a visual analogue scale (VAS). Sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI) questionnaire. Patients were treated with exogenous melatonin and signs of inflammation were assessed before and after treatment. Results: There was an improvement in sleep quality with melatonin compared with the placebo group, with no evidence of side effects. The dose of 3g exogenous melatonin was not effective for the symptom of pain. Conclusion: The poor sleep quality associated with the inflammatory state of endometriosis was controlled by the exogenous use of melatonin, reinforcing the role of sleep induction in conditions associated with chronic inflammation. However, melatonin was not effective in the pain state during treatment. The mechanisms involved in the modulation of pain in relation to the functional mechanisms of melatonin should be further investigated.
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MÁ QUALIDADE DO SONO, DOR CRÔNICA E MELATONINA DOI: https://doi.org/10.56238/arev7n2-169Palavras-chave: Ritmos circadianos, Dor, Melatonina, Dormir, EndometrioseResumo Objetivo: Considerando que as respostas inflamatórias afetam o pico noturno de melatonina e que a interrupção do sono ativa mecanismos inflamatórios que desencadeiam alterações nos sistemas efetores que regulam o sistema imunológico, aumentando a resposta inflamatória e a dor, este estudo investiga a eficácia da melatonina como tratamento para os sintomas da má qualidade do sono e dor na endometriose. Métodos: A endometriose foi diagnosticada por meio de anamnese e exames de imagem (ultrassonografia ou ressonância magnética). A intensidade da dor foi avaliada por meio de uma escala visual analógica (EVA). A qualidade do sono foi avaliada por meio do questionário Pittsburgh Sleep Quality Index (PSQI). Os pacientes foram tratados com melatonina exógena e os sinais de inflamação foram avaliados antes e após o tratamento. Resultados: Houve melhora na qualidade do sono com melatonina em comparação com o grupo placebo, sem evidência de efeitos colaterais. A dose de 3g de melatonina exógena não foi eficaz para o sintoma de dor. Conclusão: A má qualidade do sono associada ao estado inflamatório da endometriose foi controlada pelo uso exógeno de melatonina, reforçando o papel da indução do sono em condições associadas à inflamação crônica. No entanto, a melatonina não foi eficaz no estado de dor durante o tratamento. Os mecanismos envolvidos na modulação da dor em relação aos mecanismos funcionais da melatonina devem ser mais investigados.

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VAS-pain

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endometriosis

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