The clinical significance of estradiol gel applying to the therapy of operation combined with GnRHa in endometriosis

Objective To investigate the efficacy and tolerability of estradiol (E2) gel with postoperative patients of moderately severe ovarian endometriosis cyst, who suffer from the side effect of GnRH agonist. Methods Sixty samples were selected with stage Ⅲ~Ⅳ ovarian endometriosis after conservative operation by the same operator at the Department of Gynecology, Xiangya Hospital, Central South University, between February 2013 and August 2014. All of the patients after surgeries were randomly divided into three groups: control group (n=20) with only goserelin injection after conservative surgery, treatment group A (n=20) who received estradiol gel, and treatment group B (n=20) who received tibolone as an add-back therapy. The serum E2,follicle stimulating hormone (FSH), luteinizing hormone (LH), hypoestrogenic symptoms, the incidence of uterine bleeding, and the recurrence after conservative operation were compared among three groups. Results Three months later aster treatment with goserelin, the serum level of E2 of three groups showed statistically significant difference (P 0.05). The kupperman sore, the incidence of hot flashes sweating, tiring, and agrypnia of treatment groups A and B were significantly lower than the control group (P 0.05). Conclusions GnRHa combined with estradiol gel can improve symptoms of postoperative patients, reduce side effects effectively, and avoid increase of the risk of vagina bleeding and relapse. Key words: Estradiol/AD; Gels/AD; Endometriosis/TH; Gonadotropin-releasing hormone/AG/AD