Immune system and endometriosis.

Nicola Colacurci, N Colacurci, Fulvio Zullo, F Zullo, C Carravetta, Carlo Carravetta, M Galasso, Maurizio Galasso, A Di Filippo, Di Filippo A, I Strina, Ida Strina, G De Placido
Acta Europaea fertilitatis · 1992 · vol. 22(3) , pp. 161–2 · PMID:1803828 · W106083874
article OA: closed CC0 ⤵ 4 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This study compared the effects of Danazol combined with superovulation and IPI, Danazol alone with superovulation and IPI, and superovulation and IPI alone on infertility associated with endometriosis and altered macrophage activity.

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Abstract

Many experimental and clinical findings indicate a disimmune pathogenesis of infertility associated with endometriosis. The most important modifications of cell-mediated immunity in endometriosis concern macrophage activity, increased both quantitatively and qualitatively. Peritoneal macrophages (PM) acquire the ability of producing lytic enzymes, that would be able to enhancing and stimulating implantation and proliferation of endometrial cells in peritoneal cavity. In these last years many experimental and clinical demonstrations have showed an immunosuppressive action of Danazol similar to corticosteroids. The Authors report their study on a comparison among Danazol 600 mg/daily for 3 months plus a local immunosuppressive treatment combined with superovulation and IPI, Danazol for 3 months plus superovulation and IPI and, as a control group, superovulation and IPI.

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Condition tags

endometriosisinfertility

MeSH descriptors

Endometriosis Infertility, Female Danazol Danazol Endometriosis Endometriosis Endometriosis Female Humans Immunosuppression Therapy Infertility, Female Infertility, Female Insemination, Artificial Macrophages Macrophages Superovulation

Citation neighborhood (sparse)

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Cited by (4)

Cited by (4)

Source provenance

europepmc
last seen: 2026-06-11T06:19:48.454388+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-05-13T22:12:00.397535+00:00
License: CC0 · commercial use OK