Donor and recipient mismatch in liver transplantation – time for reconsideration?

Donor and recipient mismatch in liver transplantation – time for reconsideration? | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Donor and recipient mismatch in liver transplantation – time for reconsideration? Nicola Sariye Pollmann, Catherine Parmentier, Lukas Pollmann, and 1 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-8012327/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Background To find a well-matched donor is crucial for a successful liver transplantation (LT). Several factors such as a matched size, age and type of donation might benefit survival after LT, but the role of donor and recipient gender mismatch (GM) was not yet fully elucidated. Methods This single centre retrospective cohort study included a total of 1146 patients receiving LT at Ajmera transplant centre Toronto from January 2016 to January 2022. We evaluated the influence of donor/recipient age, gender and type of donor on long term survival within a 10-year observation period after LT. Results Liver transplant recipients with gender mismatch (GM+) had a significantly higher 10-year survival rate compared to recipients without gender mismatch (GM-) (p = 0.018). GM significantly influenced survival of liver transplant recipients and favored increased patient survival of female recipients (p < 0.01). Additionally, male recipients of female donors exhibited a significant improved survival compared to those with male donors. Conclusion Donor and recipient GM might not represent a risk factor for an impaired long-term survival after LT. Moreover, the composition of favorable recipient and donor characteristics seem to be the main factors influencing long term survival. Especially, female donor gender was associated with an improved survival of male transplant recipients. liver transplantation gender mismatch patient survival graft survival long-term outcome organ allocation Full Text Supplementary Files Graphicalabstract.jpeg Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-8012327","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":542728794,"identity":"44f38b64-95b3-44e2-8509-ed501cd22339","order_by":0,"name":"Nicola Sariye 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reconsideration?","fulltext":[],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":true,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"liver transplantation, gender mismatch, patient survival, graft survival, long-term outcome, organ allocation","lastPublishedDoi":"10.21203/rs.3.rs-8012327/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-8012327/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003e\u003cb\u003eBackground\u003c/b\u003e\u003c/p\u003e\u003cp\u003eTo find a well-matched donor is crucial for a successful liver transplantation (LT). Several factors such as a matched size, age and type of donation might benefit survival after LT, but the role of donor and recipient gender mismatch (GM) was not yet fully elucidated.\u003c/p\u003e\u003cp\u003e\u003cb\u003eMethods\u003c/b\u003e\u003c/p\u003e\u003cp\u003eThis single centre retrospective cohort study included a total of 1146 patients receiving LT at Ajmera transplant centre Toronto from January 2016 to January 2022. We evaluated the influence of donor/recipient age, gender and type of donor on long term survival within a 10-year observation period after LT.\u003c/p\u003e\u003cp\u003e\u003cb\u003eResults\u003c/b\u003e\u003c/p\u003e\u003cp\u003eLiver transplant recipients with gender mismatch (GM+) had a significantly higher 10-year survival rate compared to recipients without gender mismatch (GM-) (p\u0026thinsp;=\u0026thinsp;0.018). GM significantly influenced survival of liver transplant recipients and favored increased patient survival of female recipients (p\u0026thinsp;\u0026lt;\u0026thinsp;0.01). Additionally, male recipients of female donors exhibited a significant improved survival compared to those with male donors.\u003c/p\u003e\u003cp\u003e\u003cb\u003eConclusion\u003c/b\u003e\u003c/p\u003e\u003cp\u003eDonor and recipient GM might not represent a risk factor for an impaired long-term survival after LT. Moreover, the composition of favorable recipient and donor characteristics seem to be the main factors influencing long term survival. Especially, female donor gender was associated with an improved survival of male transplant recipients.\u003c/p\u003e","manuscriptTitle":"Donor and recipient mismatch in liver transplantation – time for reconsideration?","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2025-11-20 16:52:02","doi":"10.21203/rs.3.rs-8012327/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"96cebccd-dc49-407d-b1c4-aed20b5cc2ba","owner":[],"postedDate":"November 20th, 2025","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[],"tags":[],"updatedAt":"2025-12-13T05:01:51+00:00","versionOfRecord":[],"versionCreatedAt":"2025-11-20 16:52:02","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-8012327","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-8012327","identity":"rs-8012327","version":["v1"]},"buildId":"8U1c8b4HqxoKbykW_rLl7","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}