Acidic Ionic Liquid Anchored on PEG-Decorated Fe3O4 Nanoparticles: A Novel Heterogeneous and Magnetically Recoverable Organic-Inorganic Catalyst for the Efficient Synthesis of Pyrimidine Derivatives Running head: Magnetic nanohybrid acidic catalyst

Acidic Ionic Liquid Anchored on PEG-Decorated Fe3O4 Nanoparticles: A Novel Heterogeneous and Magnetically Recoverable Organic-Inorganic Catalyst for the Efficient Synthesis of Pyrimidine Derivatives Running head: Magnetic nanohybrid acidic catalyst | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Acidic Ionic Liquid Anchored on PEG-Decorated Fe 3 O 4 Nanoparticles: A Novel Heterogeneous and Magnetically Recoverable Organic-Inorganic Catalyst for the Efficient Synthesis of Pyrimidine Derivatives Running head: Magnetic nanohybrid acidic catalyst Layla A. Taib This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-6793365/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract A robust and sustainable catalytic system was developed by immobilizing a Brønsted acidic ionic liquid (BAIL) onto Fe 3 O 4 @PEG-SO₃H nanoparticles for the efficient synthesis of tetrazolopyrimidine derivatives. The fabrication of the catalyst commenced with the formation of an N-butyl sulfonate zwitterion via the reaction of N-methylimidazole with 1,4-butanesultone. Subsequently, Fe 3 O 4 @PEG-SO₃H core-shell nanoparticles were synthesized and functionalized by anchoring the zwitterion onto their surface through a reflux-assisted grafting process in ethanol. The resulting hybrid material was meticulously characterized using advanced analytical techniques, including FTIR, ¹H NMR, XRD, SEM, TEM, BET and EDX confirming its structural integrity, thermal stability, and magnetic properties. The catalytic efficacy of the hybrid was demonstrated in a one-pot multicomponent reaction involving aromatic aldehydes, active methylene compounds, and 5-aminotetrazole. Under optimized conditions, the catalyst exhibited exceptional performance, delivering high yields (85–95%) within remarkably short reaction times (15–35 minutes) at a minimal loading of 5 mol%. Furthermore, the catalyst's magnetic properties facilitated facile recovery, while its remarkable reusability was evidenced by sustained activity over four consecutive cycles with negligible loss in yield. Moreover, the introduced anchored BAIL combines the advantages of both heterogeneous and homogeneous catalysis while overcoming the limitations associated with free BAIL Core-Shell Heterogenous Organic-Inorganic Sultone Brønsted Acidic Ionic Liquid Green Chemistry tetrazolopyrimidines Figures Figure 1 Figure 2 Figure 3 Figure 4 Figure 5 Figure 6 Introduction Organic shell/inorganic core composite particles have gained attention due to their functional characteristics, excellent dispersibility, and stability provided by polymer coatings [ 1 , 2 ]. Core/shell nanostructures offer an ideal composite system, combining the benefits of both core and shell to enhance physical and chemical properties [ 3 , 4 ]. Magnetic nanoparticles (MNPs), particularly Fe 3 O 4 , have been extensively explored as inorganic cores for these composites due to their cost-effectiveness, highly reactive surfaces, large specific surface area, and ease of separation [ 5 ]. Fe 3 O 4 nanoparticles are inherently hydrophilic due to the presence of numerous hydroxyl groups on their surfaces. This hydrophilicity leads to challenges such as aggregation and poor dispersion in organic media [ 6 ]. Consequently, surface coating or modification of iron oxide nanoparticles is crucial for their effective use in various applications [ 7 ]. Recently, a variety of functionalized Fe 3 O 4 nanoparticles have been effectively employed in numerous organic reactions, showcasing their versatility and potential in chemical synthesis [ 5 , 8 ]. For example, Coating Fe 3 O 4 nanoparticles with sulfuric acid functionalized polyethylene glycol (PEG-SO 3 H) enhances their water affinity and helps prevent agglomeration, thereby improving their stability and dispersion in aqueous solutions [ 9 , 10 ]. Ionic liquids (ILs) have gained attention as effective solvents and catalysts in industrial processes [ 11 , 12 ]. Although free ionic liquids (ILs) offer notable advantages in catalysis, including high tunability and excellent solvation properties, their practical application is hampered by several intrinsic limitations. These include high synthetic cost, leaching during catalytic cycles, and difficulty in phase separation, which collectively compromise recyclability and process efficiency. Additionally, many ILs exhibit undesirable viscosity, which can impede mass transfer and reduce reaction kinetics. Concerns regarding toxicity, biodegradability, and environmental persistence further limit their green credentials. Moreover, certain ILs suffer from limited thermal or chemical stability under harsh reaction conditions, such as high temperatures or extreme pH environments. These drawbacks have driven the development of immobilized or supported ionic liquid systems to preserve their beneficial properties while enhancing operational robustness and sustainability[ 13 – 15 ]. Overcoming these obstacles is essential to fully realize the potential of ILs in large-scale organic synthesis. Supported ILs offer a promising solution by merging the properties of ILs with the benefits of heterogeneous support materials [ 16 , 17 ]. This synergy results in improved catalytic performance, cost reduction, easier recovery of ILs, and more straightforward operational processes[ 18 , 19 ]. As a result, supported ILs are becoming excellent candidates for continuous fixed-bed reactors, making them highly suitable for large-scale industrial applications [ 20 ]. With this regard, various supports such as silica, clays, organic polymers, zeolites, and metal oxides have been extensively used as supports for immobilizing ionic liquids [ 21 , 22 ]. Tetrazolopyrimidines are a significant class of compounds in medicinal chemistry due to their diverse pharmaceutical activities [ 23 , 24 ]. These heterocyclic compounds exhibit a range of biological activities, such as antitumor, antimicrobial, and antioxidant effects [ 25 , 26 ]. Moreover, they are known to stimulate the central nervous system and are being explored for potential treatments for various conditions, including obesity, diabetes, hypertension, coronary heart disease, thyroid cancer, and hepatitis B [ 27 , 28 ]. The synthesis of tetrazolopyrimidines, particularly those derived from 5-aminotetrazole, has garnered attention due to the challenges associated with traditional methods, which often involve lengthy reaction times, the use of harmful solvents, and multistep processes[ 29 ]. Recent advancements have focused on developing more efficient, eco-friendly synthetic routes [ 30 ]. Consequently, in continuation to our recent efforts for the heterogenization of BAILs, herein, we aim to decorate on the surface of Fe 3 O 4 @PEG-SO 3 H as novel solid acid catalyst for the efficient synthesis of tetrazolopyrimidines via multicomponent reaction of 5-aminotetrazole, aryl aldehydes and active methylene compounds. The objective of this study is to explore the development and application of supported BAIL (SBAILs) as efficient catalytic systems. By anchoring BAIL onto Fe 3 O 4 @PEG-SO 3 H, the resulting nanohybrid combine the advantages of homogeneous catalysis such as high activity and tunability with the ease of separation and reusability typical of heterogeneous catalysts. Immobilization enhances thermal and chemical stability, reduces leaching of active species, and allows for multiple reaction cycles with minimal performance loss. Moreover, the strategic placement of catalytic sites on the support surface can improve accessibility, leading to greater reaction efficiency and selectivity. Results and Discussion 2.1 Preparation of the BAIL anchored on Fe 3 O 4 @PEG-SO 3 H support The preparation of targeted heterogenous BAIL supported on Fe 3 O 4 @PEG-SO 3 H involves three steps. At the first, N-methylimidazole was reacted with 1,4-butane sultone under solvent free conditions at 60 ℃ to give desired organic 1-methyl,3-butyl sulfonate imidazolium salt (MImBS, Scheme 1). The spectral data (FTIR, 1 H and 13 C NMR spectra) of the synthesized organic zwitterion were compared with those reported in our previous study of this salt [4]. In the next step, Fe 3 O 4 @PEG-SO 3 H support was prepared according to the previous report with some extra modifications. PEG400 was added to Fe 3 O 4 nanoparticles in water and the mixture solution was mechanically stirred for 24 h at room temperature. After completion of the reaction, the Fe 3 O 4 @PEG400 nanoparticles were isolated with a magnet and washed with deionized water and anhydrous ethanol and dried. Lastly, Fe 3 O 4 @PEG400 was sulfonated using chlorosulfonic acid (ClSO 3 H) to furnish Fe 3 O 4 @PEG-SO 3 H (Scheme 2). The final step of decoration of MImBS on the surface of Fe 3 O 4 @PEG-SO 3 H support, MImBS and Fe 3 O 4 @PEG-SO 3 H were mixed in ethanol and the reaction was followed under reflux condition to complete proton transferring process from support to MImBS salt which was named as Fe 3 O 4 @PEG-SO 3 H@BAIL (Scheme 2). 2.2 Characterization of the novel nano Fe 3 O 4 @PEG-SO 3 H@BAIL After non-covalent ion-pair anchoring BAIL on the surface of nano magnetic organic-inorganic hybrid support, several characterization techniques such as 1 H and 13 C NMR, FT-IR, SEM, TEM, BET, XRD and EDX were used to approve its successful fabrication. 2.2.1 FTIR FTIR spectroscopy was utilized to confirm the existence of the main functional groups in synthesized acidic nanohybrid catalyst ( Fig. 1 ). The FTIR spectrum of finalized Fe 3 O 4 @PEG-SO 3 H@BAIL shows almost all vibrations peaks related to the main functional groups included in its structure. As illustrated in Fig. 1c, a peak at 597 cm −1 is attributed to the Fe–O–Fe stretching vibration. Moreover, a broad O–H stretch around 3432 cm −1 is observed. The bands at 2931 and 2869 cm −1 correspond to the aliphatic C–H stretching vibrations, indicating successful PEG functionalization on the Fe 3 O 4 nanoparticle surface. Furthermore, aromatic C–H stretching vibrations are existed at 3097 and 3147 cm −1 that are clear and strong proof for successful decorating of MImBS zwitterion on the surface of Fe 3 O 4 @PEG-SO 3 H support. Additionally, typical absorption peaks at 1184, 1049 cm -1 are denoted to asymmetric and symmetric stretching vibrations of the sulfonate group respectively. The stretching vibrations of C=N from the imidazolium is observed at 1569 cm −1 which is another evidence for non-covalent anchoring of MImBS on the surface of the support. 2.2.2 SEM, TEM The FE-SEM image of Fe 3 O 4 @PEG-SO 3 H@BAIL revealed that the nanoparticles of the prepared hybrid catalyst have almost spherical shape and morphology. Moreover, some aggregation of Fe 3 O 4 MNP was observed ( Fig. 2 ). The TEM image of decorated BAIL on Fe 3 O 4 @PEG-SO 3 H support confirmed the existence of a two-phase system in which an organic layer shell is coated on the surface of Fe 3 O 4 . Moreover, partial aggregation of Fe 3 O 4 MNP is also observable in TEM image ( Fig. 3 ). 2.2.3 BET analysis BET surface area analysis revealed a progressive decrease in porosity upon successive functionalization steps. The bare Fe 3 O 4 nanoparticles exhibited a specific surface area of 120 m 2 /g. Following surface modification with PEG-SO 3 H and immobilization of the BAIL (Fe 3 O 4 @PEG-SO 3 H@BAIL), the surface area decreased to 92 m 2 /g, and further dropped to 78 m 2 /g after grafting of the BAIL moiety. This trend is consistent with effective tethering of organic functionalities onto the magnetic core, resulting in partial pore blockage or increased surface coverage. Such a systematic reduction in surface area provides strong support for the formation of a structurally intact, covalently anchored catalytic system. 2.2.4 XRD and EDX The successful preparation of Fe 3 O 4 @PEG-SO 3 H@BAIL was also approved by EDX detector coupled with FESEM. The EDX analysis of Fe 3 O 4 @PEG-SO 3 H@BAIL exhibited C, N, O, S, and Fe elements dispersed homogenously in the structure of the prepared catalyst ( Fig. 4 ). The XRD pattern of the introduced Fe 3 O 4 @PEG-SO 3 H@BAIL is presented in Fig. 5 . It was observed that the set of diffraction peaks are associated with magnetic cubic structure of Fe 3 O 4 . However, these diffraction peaks are broader than diffraction peaks of pure crystallin Fe 3 O 4 which raised from the influence of amorphous coated organic phase which is further proof for the existence of core-shell structure in Fe 3 O 4 @PEG-SO 3 H@BAIL hybrid. 2.3 Synthesis of tetrazolopyrimidines via catalytic processes in the presence of Fe 3 O 4 @PEG-SO 3 H@BAIL The construction of biologically significant tetrazolopyrimidine frameworks was accomplished through a multicomponent reaction (MCR) protocol involving 5-aminotetrazole, aldehydes, and active methylene compounds such as dimedone or ethyl acetoacetate. This transformation was mediated by a novel non-covalently anchored BAIL on Fe3O4@PEG400-SO3H support functioning as a magnetic heterogeneous acid catalyst. To systematically evaluate the catalytic efficiency of the introduced solid organic-inorganic acidic hybrid, the model reaction between benzaldehyde, 5-aminotetrazole, and ethyl acetoacetate was selected. In line with green chemistry principles, all optimization reactions were conducted under solvent-free conditions to minimize environmental impact and enhance sustainability. Under uncatalyzed conditions, the reaction showed no progress even after extended periods at ambient temperature or under thermal activation (Table 1, entries 1, 2). This observation underscores the necessity of an acidic promoter to facilitate the desired transformation. When conventional homogeneous acid such as sulfuric acid was employed, the target tetrazolopyrimidine derivative was obtained within 1 hour, albeit with moderate yields. These results confirm the pivotal role of proton transfer in activating the substrates and driving the reaction forward. The optimal quantity of the hybrid catalyst Fe 3 O 4 @PEG-SO 3 H@BAIL was established at 10 mmol% (20 mg), ensuring maximum efficiency in the reaction system. Under optimized conditions, the reaction achieved maximal product yield of 93% when conducted at 110°C with the precise catalyst dosage (entry 8). Notably, exceeding the optimal catalyst amount or elevating the reaction temperature failed to produce any significant improvement in either reaction kinetics or product yield (entries 9, 10), indicating that these parameters are already at their efficacy limit for this transformation. This observation underscores the critical balance between catalyst loading, thermal activation, and substrate conversion in achieving optimal synthetic outcomes. Notably, the introduction of the prepared magnetic solid acid catalyst significantly enhanced the reaction efficiency. The tunable acidity and robust structural stability of introduced catalyst, enabled the formation of the desired product with improved yield. The superior performance of this hybrid catalyst can be attributed to its dual functionality, combining the advantages of both organic moieties (e.g., enhanced substrate affinity) and inorganic components (e.g., high surface area and thermal stability). Furthermore, the recyclability and reusability of these catalysts were demonstrated, aligning with the principles of sustainable chemical synthesis. Table 1 Optimization of the reaction parameters for the synthesis of tetrazolopyrimidines catalyzed by novel Fe 3 O 4 @PEG-SO 3 H@BAIL The synthetic utility of the reaction was broadened by investigating a one-pot, three-component coupling involving a variety of aromatic aldehydes, active methylene compounds (dimedone or ethyl acetoacetate), and 5-aminotetrazole. These transformations were facilitated by a newly developed organic-inorganic nanohybrid catalyst, Fe 3 O 4 @PEG-SO 3 H@BAIL. The protocol enabled access to two distinct heterocyclic frameworks: methyl-7-aryl-4,7-dihydrotetrazolo[1,5-a]pyrimidine-6-carboxylates (D) and 6,6-dimethyl-9-aryl-5,6,7,9-tetrahydrotetrazolo[5,1-b]quinazolin-8(4H)-ones (E). A detailed summary of the results is provided in Table 2. A diverse array of aromatic aldehydes, featuring both electron-withdrawing and electron-donating functionalities, was employed under standardized conditions. Aldehydes substituted with electron-withdrawing groups displayed markedly enhanced reactivity compared to their electron-rich analogs, reflecting the critical role of electronic effects in substrate activation. Additionally, the formation of 6,6-dimethyl-9-aryl-5,6,7,9-tetrahydrotetrazolo[5,1-b]quinazolin-8(4H)-ones proceeded at a faster rate than the synthesis of methyl-7-aryl-4,7-dihydrotetrazolo[1,5-a]pyrimidine-6-carboxylates, requiring shorter reaction times under identical conditions. Table 3 BAISs catalyzed the preparation of tetrazolopyrimidines Product A Active methylene compounds T (min) Yield(%) a Mp(̊C) D1 C 6 H 5 CHO B 25 91 203-205 [31] D2 4-MeOC 6 H 4 CHO B 35 87 193-195 [32] D3 2,4-DiCl-C 6 H 3 CHO B 20 90 255-257 [33] D4 2-NO 2 C 6 H 4 CHO B 20 89 240-242 [32] E1 C 6 H 5 CHO C 15 88 272-274 [31] E2 4-MeOC 6 H 4 CHO C 20 91 225-227 [33] E3 2-NO 2 C 6 H 4 CHO C 20 88 260-262 [32] E4 2,4-DiCl-C 6 H 3 CHO C 15 92 >270 [33] E5 4-BrC 6 H 4 CHO C 25 90 247-249 [31] a Isolated Yield 2.4 Recyclability study of the prepared nanohybrid catalyst To assess the durability and reusability of the fabricated protic IL anchored on Fe 3 O 4 @PEG 400 SO 3 H support, the model reaction from Table 1 was repeated under optimized conditions. The reactions were performed at 110°C in a solvent-free environment using the predetermined optimal catalyst loading. Reaction progress was tracked via thin-layer chromatography (TLC) until completion. Upon cooling the reaction mixture to room temperature, 10 mL of acetone was introduced, and the mixture was stirred for an additional 5 minutes. The heterogeneous catalyst was extracted by an external magnet. The remained suspension was concentrated under reduced pressure, and the resulting crude product was purified by recrystallization from hot ethanol, yielding the desired tetrazolopyrimidine derivative in high purity. The recovered magnetic catalyst was meticulously washed with acetone to eliminate any residual contaminants and subsequently dried at 80°C in preparation for reuse in subsequent cycles. The stability profile of the catalysts over multiple runs is illustrated in Fig. 9. Remarkably, the yield of the reaction remained nearly constant across six consecutive cycles, with the reaction time consistently maintained at 30 minutes for all tested catalysts. These results demonstrate that the catalytic activity and structural integrity of the three hybrid materials are largely preserved even after four successive applications, highlighting their remarkable robustness and potential for sustainable synthetic processes. A proposed mechanism detailing the catalytic involvement of the green heterogeneous organic-inorganic acidic catalyst in the synthesis of tetrazolopyrimidine derivatives (D and E) is illustrated in Scheme 4. The process initiates with the protonation of the aromatic aldehyde by the acidic functionalities of the acidic nanohybrid catalyst, which enhances its electrophilicity. Concurrently, the active methylene compound undergoes enolization, a transformation facilitated by the catalytic environment provided by the hybrid system. Next, a reaction resembling aldol condensation occurs between the activated aldehyde and the enolized form of the active methylene species. Following this, the nucleophilic addition of 5-aminotetrazole to the Michael acceptor, activated by the catalyst, takes place. This step is succeeded by an intramolecular cyclization, driven by the catalyst's ability to promote heterocyclic ring formation. Finally, dehydration, mediated by the nanohybrid catalyst, completes the sequence, yielding the desired tetrazolopyrimidine products (D and E). This mechanistic framework highlights the versatility of the introduced catalyst, which orchestrate multiple steps including activation, condensation, cyclization, and dehydration ensuring the efficient construction of the target heterocyclic frameworks under mild conditions. Conclusion In this work, we have successfully developed and introduced a cutting-edge Brønsted acidic ionic liquid (BAIL) immobilized on Fe₃O₄@PEG-SO₃H nanoparticles as a highly efficient and sustainable catalyst for the synthesis of tetrazolopyrimidines. The synthesis of this hybrid material involved a multi-step process, beginning with the formation of an N-butyl sulfonate zwitterion from N-methylimidazole and 1,4-butanesultone, followed by the preparation of Fe₃O₄@PEG-SO₃H core-shell nanoparticles. The final step integrated the zwitterion onto the nanoparticle surface, resulting in a robust and magnetically recoverable catalyst. The catalytic performance of this novel organic-inorganic nanohybrid was demonstrated through a multicomponent reaction involving aromatic aldehydes, active methylene compounds, and 5-aminotetrazole. Remarkably, the catalyst achieved exceptional yields (85–95%) in remarkably short reaction times (15–35 minutes) while requiring only a minimal loading of 5 mmol%. This highlights not only its superior catalytic efficiency but also its ability to streamline synthetic processes, making it an attractive option for both academic and industrial applications. One of the standout features of this hybrid catalyst is its ease of recovery and remarkable reusability. Through simple magnetic separation, the catalyst could be recovered without significant loss of activity, maintaining high yields over at least four consecutive cycles. This recyclability addresses a critical challenge in modern catalysis by reducing waste and promoting sustainability, aligning perfectly with the principles of green chemistry. Overall, this study underscores the immense potential of organic-inorganic hybrid materials in advancing catalytic methodologies. The combination of high efficiency, operational simplicity, and excellent recyclability makes this novel Fe 3 O 4 @PEG-SO 3 H-supported BAIL catalyst a groundbreaking tool for the synthesis of heterocyclic compounds like tetrazolopyrimidines. Its versatility and eco-friendly design pave the way for broader applications in organic synthesis, offering researchers a powerful and sustainable alternative to traditional catalytic systems. This work not only contributes to the field of catalysis but also sets a benchmark for the future development of advanced hybrid materials in chemical transformations. Experimental 3.1 Synthesis of organic zwitterion N -methylimidazole (15 mmol) and 1,4-butanesultone (17 mmol) mixture was introduced into a round-bottom flask fitted with a magnetic stir bar. The reaction was conducted under a nitrogen blanket at 75 °C with continuous stirring until completion. Upon cooling, the crude product was isolated as a white precipitate via filtration, followed by rigorous purification through sequential washing with diethyl ether and acetone. After drying, the final product, identified as MImBs, was obtained as a white solid in quantitative yield (95%). 3.2 Synthesis and Surface Modification of Fe 3 O 4 -Based Magnetic Nanoparticles Fe 3 O 4 @PEG400-SO 3 H The fabrication of Fe 3 O 4 nanoparticles was accomplished via a controlled precipitation process. A mixture of FeCl 2 ·4H 2 O (2 g) and FeCl 3 ·6H₂O (5.3 g) was dissolved in 30 mL of degassed water, with the addition of 0.85 mL of concentrated hydrochloric acid. This solution was gradually added to 250 mL of a preheated 1.5 M NaOH solution under continuous agitation and an inert nitrogen atmosphere at 80 °C. The resulting magnetic particles were isolated using a strong magnet, rinsed three times with 200 mL of purified water, and dried at 40 °C. To improve their stability and compatibility, the Fe 3 O 4 nanoparticles were coated with polyethylene glycol 400 (PEG400). Fe 3 O 4 (1 g) was suspended in 100 mL of water using ultrasonic energy for 20 minutes. PEG400 (1 g) was then incorporated, and the system was mechanically agitated for 24 h at ambient temperature. The modified nanoparticles, Fe₃O₄@PEG400, were magnetically extracted, washed with purified water and ethanol, and dried at 40 °C. Further modification involved the introduction of sulfonic acid groups to impart acidic functionality. A sample of 1 g of Fe 3 O 4 @PEG400 was dispersed in 50 mL of anhydrous CH 2 Cl 2 using ultrasonication for 20 min. Chlorosulfonic acid (0.4 mL) was added dropwise over 30 min at room temperature, followed by stirring for an additional 5 h to ensure complete functionalization. The resulting material, Fe 3 O 4 @PEG400-SO 3 H, was separated magnetically, thoroughly washed with CH 2 Cl 2 and acetone, and dried under ambient conditions (Scheme 2). The concentration of acidic sites on the Fe 3 O 4 @PEG400-SO 3 H hybrid was determined using a titrimetric approach. A 0.1 g sample was reacted with 10 mL of 0.130 N NaOH for 30 min. After magnetic separation and washing with water, the unreacted NaOH was titrated with 0.337 N HCl in the presence of phenolphthalein as an endpoint indicator. The analysis confirmed an acidic site density of 1.35 mmol g -1 . 3.3 Preparation of Fe 3 O 4 @PEG400-SO 3 H@BAIL A round-bottom flask was charged with Fe 3 O 4 @PEG400-SO 3 H (10 g) and the MImBs zwitterion (12 mmol) in 50 mL of ethanol. The mixture was refluxed under continuous stirring for 12 h to facilitate the incorporation of the zwitterion onto the hybrid material. Following the reaction, the non-covalently anchored BAIL on the magnetic support (Fe 3 O 4 @PEG400-SO 3 H@BAIL) was extracted by a magnet which was then thoroughly washed with water to remove any unbound zwitterionic species. The obtained solid was dried under vacuum at 50 °C for 8 hours to eliminate residual solvents, yielding the final pure organic-inorganic catalytic system. 3.4. General procedure for the synthesis of tetrazolopyrimidine derivatives catalyzed by novel introduced Fe 3 O 4 @PEG400-SO 3 H@BAIL organic-inorganic hybrids A reaction mixture consisting of aromatic aldehyde A (1 mmol), active methylene compound B or C (1 mmol), and 5-aminotetrazole (1 mmol) was prepared. To this, an optimized loading of 2 mol% Fe 3 O 4 @PEG400-SO3H@BAIL catalyst was introduced. The temperature was raised to 110 °C, and the mixture was stirred magnetically for a duration determined according to Table 2. Reaction progress was monitored by TLC using n-hexane:ethyl acetate (2:1) as the eluent. Upon completion, the reaction mixture was cooled to room temperature, and 10 mL of acetone was added, followed by stirring for 5 minutes. The catalyst was then separated using an external magnet, thoroughly washed with acetone, and dried for reuse in subsequent reactions. The remaining solution was concentrated under reduced pressure, and the resulting solid was recrystallized from hot ethanol (2 × 25 mL) to yield the target tetrazolopyrimidine derivative in pure form. All synthesized products were identified as known compounds and characterized using IR and NMR spectroscopy, along with CHN elemental analysis for novel derivatives. Melting points were measured and compared with reported literature values for verification [27, 34, 35]. Declarations Disclosure of interest: The author reports there are no competing interests to declare Author Contribution Layla A. Taib conceptualized and designed the entire study, conducted all experiments, collected and analyzed data, and interpreted the results. She was solely responsible for drafting the manuscript, creating figures, and preparing the final version for submission. Acknowledgement The author gratefully acknowledges to the Research Council of King Abdulaziz University for financial support of this work. 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Yazdankish, A Sulfonated Phenanthrolinum Salt of Phosphotungstate as Novel Catalyst for the Efficient Synthesis of 3, 3′-Diaryloxindoles, Polycyclic Aromatic Compounds, 41 (2021) 427-439. A. Olyaei, M. Sadeghpour, Chemistry of 3-cyanoacetyl indoles: synthesis, reactions and applications: a recent update, RSC advances, 13 (2023) 21710-21745. Y. Zhong, Arylformylacetonitriles in multicomponent reactions leading to heterocycles, European Journal of Organic Chemistry, 2022 (2022) e202201038. S. Sharma, M.A. Babu, R. Kumar, T.G. Singh, A.R. Dwivedi, G. Ahmad, K.K. Goel, B. Kumar, A review on pyrimidine-based pharmacophore as a template for the development of hybrid drugs with anticancer potential, Molecular Diversity, (2025) 1-23. R. Natarajan, H.N. Anthoni Samy, A. Sivaperuman, A. Subramani, Structure-activity relationships of pyrimidine derivatives and their biological activity-A review, Medicinal Chemistry, 19 (2023) 10-30. K. Singh, R. Pal, S.A. Khan, B. Kumar, M.J. Akhtar, Insights into the structure activity relationship of nitrogen-containing heterocyclics for the development of antidepressant compounds: An updated review, Journal of Molecular Structure, 1237 (2021) 130369. B. Banerjee, A. Sharma, A. Singh, M. Kaur, A. Priya, Synthesis of Isatin-derived Heterocycles with Promising Anticancer Activities, Current Topics in Medicinal Chemistry, 25 (2025) 96-123. S. Leyva-Ramos, J. Cardoso-Ortiz, Recent developments in the synthesis of tetrazoles and their pharmacological relevance, Current Organic Chemistry, 25 (2021) 388-403. N. Jangir, Poonam, S. Dhadda, D.K. Jangid, Recent advances in the synthesis of five‐and six‐membered heterocycles as bioactive skeleton: A concise overview, ChemistrySelect, 7 (2022) e202103139. L.-Y. Zeng, C. Cai, Iodine catalyzed one-pot multicomponent synthesis of a library of compounds containing tetrazolo [1, 5-a] pyrimidine core, Journal of Combinatorial Chemistry, 12 (2010) 35-40. L.A. Taib, M. Keshavarz, Non-covalent immobilized sultone based protic ionic liquids on nano silica sulfuric acid as novel heterogeneous catalysts for the efficient synthesis of tetrazolopyrimidines, Journal of Porous Materials, (2022). A. Hassankhani, B. Gholipour, S. Rostamnia, An efficient regioselective three-component synthesis of tetrazoloquinazolines using g-C3N4 covalently bonded sulfamic acid, Polyhedron, 175 (2020) 114217. Schemes Schemes 1 to 4 are available in the Supplementary Files section. Additional Declarations No competing interests reported. Supplementary Files Scheme1.png Scheme 1 preparation of organic zwitterion Scheme2.png Scheme 2 preparation pathway for decorating BAIL on magnetic nano support Scheme3.png Scheme 3 Synthesis of tetrazolopyrimidines catalyzed by fabricated non-covalent supported protic IL catalyst Scheme4.png Scheme 4 Mechanistic insights into the presented nanohybrid-Catalyzed preparation of Tetrazolopyrimidine Scaffolds GraphicalAbstract.docx Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-6793365","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":465562041,"identity":"e0e36dc0-c493-4ec3-b5a0-faf4e2a5de7d","order_by":0,"name":"Layla A. Taib","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAAvklEQVRIiWNgGAWjYBACPiA+zFCRAOZIEKWFjQ2k5QypWpgZ20jSIt/88HDhvDR5gwPMB2/zMNTJE2ELm8HhmdtyDDccYEu25mE4bNhAhMMMDvNuq2DccIDHTJqH4QAjEVrYPxzmnVNhv+EA/zegljp7IrTwAG1pyEkE2sIG1MKcSISWnILDM46lJc88zGZsOcfgcDJBLfzMxzd/LqhJtu073vzwxpuKOluCWhCAGUQYEK9+FIyCUTAKRgEeAABiHzZGnLjTjwAAAABJRU5ErkJggg==","orcid":"","institution":"King Abdulaziz University","correspondingAuthor":true,"prefix":"","firstName":"Layla","middleName":"A.","lastName":"Taib","suffix":""}],"badges":[],"createdAt":"2025-06-01 02:23:07","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-6793365/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-6793365/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":84458906,"identity":"57552fa2-4035-415d-aa63-a34fae4a4103","added_by":"auto","created_at":"2025-06-12 08:29:31","extension":"png","order_by":1,"title":"Figure 1","display":"","copyAsset":false,"role":"figure","size":167843,"visible":true,"origin":"","legend":"\u003cp\u003eFTIR spectra of MImBS (a), Fe\u003csub\u003e3\u003c/sub\u003eO\u003csub\u003e4\u003c/sub\u003e@PEG-SO\u003csub\u003e3\u003c/sub\u003eH (b), Fe\u003csub\u003e3\u003c/sub\u003eO\u003csub\u003e4\u003c/sub\u003e@PEG-SO\u003csub\u003e3\u003c/sub\u003eH@BAIL (c)\u003c/p\u003e","description":"","filename":"1.png","url":"https://assets-eu.researchsquare.com/files/rs-6793365/v1/cb70561b7b2329819afcd435.png"},{"id":84460435,"identity":"4e6d4526-43dc-49f2-ad02-93acb76a93e4","added_by":"auto","created_at":"2025-06-12 08:45:31","extension":"png","order_by":2,"title":"Figure 2","display":"","copyAsset":false,"role":"figure","size":509098,"visible":true,"origin":"","legend":"\u003cp\u003eFESEM image of Fe\u003csub\u003e3\u003c/sub\u003eO\u003csub\u003e4\u003c/sub\u003e@PEG-SO\u003csub\u003e3\u003c/sub\u003eH@BAIL\u003c/p\u003e","description":"","filename":"2.png","url":"https://assets-eu.researchsquare.com/files/rs-6793365/v1/5d43dfc414b7b5f695e3368f.png"},{"id":84460437,"identity":"4a10fafa-6a6b-43f7-ad6d-16816026637f","added_by":"auto","created_at":"2025-06-12 08:45:31","extension":"png","order_by":3,"title":"Figure 3","display":"","copyAsset":false,"role":"figure","size":586374,"visible":true,"origin":"","legend":"\u003cp\u003eTEM image of Fe\u003csub\u003e3\u003c/sub\u003eO\u003csub\u003e4\u003c/sub\u003e@PEG-SO\u003csub\u003e3\u003c/sub\u003eH@BAIL\u003c/p\u003e","description":"","filename":"3.png","url":"https://assets-eu.researchsquare.com/files/rs-6793365/v1/b68516310886bbd0ee90c382.png"},{"id":84458919,"identity":"c78b9332-9238-43f8-b6a2-92862e70801d","added_by":"auto","created_at":"2025-06-12 08:29:31","extension":"png","order_by":4,"title":"Figure 4","display":"","copyAsset":false,"role":"figure","size":132020,"visible":true,"origin":"","legend":"\u003cp\u003eEDX analysis of Fe\u003csub\u003e3\u003c/sub\u003eO\u003csub\u003e4\u003c/sub\u003e@PEG-SO\u003csub\u003e3\u003c/sub\u003eH@BAIL\u003c/p\u003e","description":"","filename":"4.png","url":"https://assets-eu.researchsquare.com/files/rs-6793365/v1/b8914feb6cb5d2ada394b3ed.png"},{"id":84459489,"identity":"d59ee2f9-bd05-473f-8cb1-bc11a9ab87d4","added_by":"auto","created_at":"2025-06-12 08:37:31","extension":"png","order_by":5,"title":"Figure 5","display":"","copyAsset":false,"role":"figure","size":127431,"visible":true,"origin":"","legend":"\u003cp\u003eXRD spectrum of Fe\u003csub\u003e3\u003c/sub\u003eO\u003csub\u003e4\u003c/sub\u003e@PEG-SO\u003csub\u003e3\u003c/sub\u003eH@BAIL\u003c/p\u003e","description":"","filename":"5.png","url":"https://assets-eu.researchsquare.com/files/rs-6793365/v1/084538d63e48e5b83d5d9445.png"},{"id":84458923,"identity":"f6c2a762-698d-4429-ac67-58020e324fe3","added_by":"auto","created_at":"2025-06-12 08:29:31","extension":"png","order_by":6,"title":"Figure 6","display":"","copyAsset":false,"role":"figure","size":90022,"visible":true,"origin":"","legend":"\u003cp\u003eFig. 9 Reusability study of Fe\u003csub\u003e3\u003c/sub\u003eO\u003csub\u003e4\u003c/sub\u003e@PEG-SO\u003csub\u003e3\u003c/sub\u003eH@BAIL catalyst for the synthesis of tetrazolopyrimidine product\u003c/p\u003e","description":"","filename":"9.png","url":"https://assets-eu.researchsquare.com/files/rs-6793365/v1/4bf75cd5fada2ccae4eaa668.png"},{"id":86927489,"identity":"58f3f525-bf2b-4f0e-9792-c21fca0b577d","added_by":"auto","created_at":"2025-07-17 09:02:22","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":2532085,"visible":true,"origin":"","legend":"","description":"","filename":"manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-6793365/v1/b06c201c-109c-4470-9f74-f7902f4a38e9.pdf"},{"id":84459485,"identity":"ed0c6253-17b4-4aaf-b6de-0f948235ca8f","added_by":"auto","created_at":"2025-06-12 08:37:31","extension":"png","order_by":1,"title":"","display":"","copyAsset":false,"role":"supplement","size":9889,"visible":true,"origin":"","legend":"\u003cp\u003eScheme 1 preparation of organic zwitterion\u003c/p\u003e","description":"","filename":"Scheme1.png","url":"https://assets-eu.researchsquare.com/files/rs-6793365/v1/2056cdca6158c17bc930617e.png"},{"id":84458908,"identity":"62207b10-36ab-430d-8e07-e45b8233d773","added_by":"auto","created_at":"2025-06-12 08:29:31","extension":"png","order_by":2,"title":"","display":"","copyAsset":false,"role":"supplement","size":127588,"visible":true,"origin":"","legend":"\u003cp\u003eScheme 2 preparation pathway for decorating BAIL on magnetic nano support\u003c/p\u003e","description":"","filename":"Scheme2.png","url":"https://assets-eu.researchsquare.com/files/rs-6793365/v1/b4e845f865310e8f57fa2427.png"},{"id":84458912,"identity":"f5a09782-21d9-4872-894a-65115e41ccf4","added_by":"auto","created_at":"2025-06-12 08:29:31","extension":"png","order_by":3,"title":"","display":"","copyAsset":false,"role":"supplement","size":222526,"visible":true,"origin":"","legend":"\u003cp\u003e\u003cstrong\u003eScheme 3\u003c/strong\u003e Synthesis of tetrazolopyrimidines catalyzed by fabricated non-covalent supported protic IL catalyst\u003c/p\u003e","description":"","filename":"Scheme3.png","url":"https://assets-eu.researchsquare.com/files/rs-6793365/v1/b71b1555e627e06ec6a2b74f.png"},{"id":84459487,"identity":"74830889-0fb8-4024-ac7c-e8aa3a18da0d","added_by":"auto","created_at":"2025-06-12 08:37:31","extension":"png","order_by":4,"title":"","display":"","copyAsset":false,"role":"supplement","size":98342,"visible":true,"origin":"","legend":"\u003cp\u003eScheme 4 Mechanistic insights into the presented nanohybrid-Catalyzed preparation of Tetrazolopyrimidine Scaffolds\u003c/p\u003e","description":"","filename":"Scheme4.png","url":"https://assets-eu.researchsquare.com/files/rs-6793365/v1/44d8e333b5e82a1532a5ed38.png"},{"id":84458931,"identity":"3ccf11de-3f62-40f8-9077-5784f7a5f3ba","added_by":"auto","created_at":"2025-06-12 08:29:32","extension":"docx","order_by":5,"title":"","display":"","copyAsset":false,"role":"supplement","size":760382,"visible":true,"origin":"","legend":"","description":"","filename":"GraphicalAbstract.docx","url":"https://assets-eu.researchsquare.com/files/rs-6793365/v1/23674689778020218adf31ef.docx"}],"financialInterests":"No competing interests reported.","formattedTitle":"\u003cp\u003eAcidic Ionic Liquid Anchored on PEG-Decorated Fe\u003csub\u003e3\u003c/sub\u003eO\u003csub\u003e4\u003c/sub\u003e Nanoparticles: A Novel Heterogeneous and Magnetically Recoverable Organic-Inorganic Catalyst for the Efficient Synthesis of Pyrimidine Derivatives\u003c/p\u003e\n\u003cp\u003eRunning head: Magnetic nanohybrid acidic catalyst\u003c/p\u003e","fulltext":[{"header":"Introduction","content":"\u003cp\u003eOrganic shell/inorganic core composite particles have gained attention due to their functional characteristics, excellent dispersibility, and stability provided by polymer coatings [\u003cspan citationid=\"CR1\" class=\"CitationRef\"\u003e1\u003c/span\u003e, \u003cspan citationid=\"CR2\" class=\"CitationRef\"\u003e2\u003c/span\u003e]. Core/shell nanostructures offer an ideal composite system, combining the benefits of both core and shell to enhance physical and chemical properties [\u003cspan citationid=\"CR3\" class=\"CitationRef\"\u003e3\u003c/span\u003e, \u003cspan citationid=\"CR4\" class=\"CitationRef\"\u003e4\u003c/span\u003e]. Magnetic nanoparticles (MNPs), particularly Fe\u003csub\u003e3\u003c/sub\u003eO\u003csub\u003e4\u003c/sub\u003e, have been extensively explored as inorganic cores for these composites due to their cost-effectiveness, highly reactive surfaces, large specific surface area, and ease of separation [\u003cspan citationid=\"CR5\" class=\"CitationRef\"\u003e5\u003c/span\u003e]. Fe\u003csub\u003e3\u003c/sub\u003eO\u003csub\u003e4\u003c/sub\u003e nanoparticles are inherently hydrophilic due to the presence of numerous hydroxyl groups on their surfaces. This hydrophilicity leads to challenges such as aggregation and poor dispersion in organic media [\u003cspan citationid=\"CR6\" class=\"CitationRef\"\u003e6\u003c/span\u003e]. Consequently, surface coating or modification of iron oxide nanoparticles is crucial for their effective use in various applications [\u003cspan citationid=\"CR7\" class=\"CitationRef\"\u003e7\u003c/span\u003e]. Recently, a variety of functionalized Fe\u003csub\u003e3\u003c/sub\u003eO\u003csub\u003e4\u003c/sub\u003e nanoparticles have been effectively employed in numerous organic reactions, showcasing their versatility and potential in chemical synthesis [\u003cspan citationid=\"CR5\" class=\"CitationRef\"\u003e5\u003c/span\u003e, \u003cspan citationid=\"CR8\" class=\"CitationRef\"\u003e8\u003c/span\u003e]. For example, Coating Fe\u003csub\u003e3\u003c/sub\u003eO\u003csub\u003e4\u003c/sub\u003e nanoparticles with sulfuric acid functionalized polyethylene glycol (PEG-SO\u003csub\u003e3\u003c/sub\u003eH) enhances their water affinity and helps prevent agglomeration, thereby improving their stability and dispersion in aqueous solutions [\u003cspan citationid=\"CR9\" class=\"CitationRef\"\u003e9\u003c/span\u003e, \u003cspan citationid=\"CR10\" class=\"CitationRef\"\u003e10\u003c/span\u003e].\u003c/p\u003e \u003cp\u003eIonic liquids (ILs) have gained attention as effective solvents and catalysts in industrial processes [\u003cspan citationid=\"CR11\" class=\"CitationRef\"\u003e11\u003c/span\u003e, \u003cspan citationid=\"CR12\" class=\"CitationRef\"\u003e12\u003c/span\u003e]. Although free ionic liquids (ILs) offer notable advantages in catalysis, including high tunability and excellent solvation properties, their practical application is hampered by several intrinsic limitations. These include high synthetic cost, leaching during catalytic cycles, and difficulty in phase separation, which collectively compromise recyclability and process efficiency. Additionally, many ILs exhibit undesirable viscosity, which can impede mass transfer and reduce reaction kinetics. Concerns regarding toxicity, biodegradability, and environmental persistence further limit their green credentials. Moreover, certain ILs suffer from limited thermal or chemical stability under harsh reaction conditions, such as high temperatures or extreme pH environments. These drawbacks have driven the development of immobilized or supported ionic liquid systems to preserve their beneficial properties while enhancing operational robustness and sustainability[\u003cspan additionalcitationids=\"CR14\" citationid=\"CR13\" class=\"CitationRef\"\u003e13\u003c/span\u003e\u0026ndash;\u003cspan citationid=\"CR15\" class=\"CitationRef\"\u003e15\u003c/span\u003e]. Overcoming these obstacles is essential to fully realize the potential of ILs in large-scale organic synthesis. Supported ILs offer a promising solution by merging the properties of ILs with the benefits of heterogeneous support materials [\u003cspan citationid=\"CR16\" class=\"CitationRef\"\u003e16\u003c/span\u003e, \u003cspan citationid=\"CR17\" class=\"CitationRef\"\u003e17\u003c/span\u003e]. This synergy results in improved catalytic performance, cost reduction, easier recovery of ILs, and more straightforward operational processes[\u003cspan citationid=\"CR18\" class=\"CitationRef\"\u003e18\u003c/span\u003e, \u003cspan citationid=\"CR19\" class=\"CitationRef\"\u003e19\u003c/span\u003e]. As a result, supported ILs are becoming excellent candidates for continuous fixed-bed reactors, making them highly suitable for large-scale industrial applications [\u003cspan citationid=\"CR20\" class=\"CitationRef\"\u003e20\u003c/span\u003e]. With this regard, various supports such as silica, clays, organic polymers, zeolites, and metal oxides have been extensively used as supports for immobilizing ionic liquids [\u003cspan citationid=\"CR21\" class=\"CitationRef\"\u003e21\u003c/span\u003e, \u003cspan citationid=\"CR22\" class=\"CitationRef\"\u003e22\u003c/span\u003e].\u003c/p\u003e \u003cp\u003eTetrazolopyrimidines are a significant class of compounds in medicinal chemistry due to their diverse pharmaceutical activities [\u003cspan citationid=\"CR23\" class=\"CitationRef\"\u003e23\u003c/span\u003e, \u003cspan citationid=\"CR24\" class=\"CitationRef\"\u003e24\u003c/span\u003e]. These heterocyclic compounds exhibit a range of biological activities, such as antitumor, antimicrobial, and antioxidant effects [\u003cspan citationid=\"CR25\" class=\"CitationRef\"\u003e25\u003c/span\u003e, \u003cspan citationid=\"CR26\" class=\"CitationRef\"\u003e26\u003c/span\u003e]. Moreover, they are known to stimulate the central nervous system and are being explored for potential treatments for various conditions, including obesity, diabetes, hypertension, coronary heart disease, thyroid cancer, and hepatitis B [\u003cspan citationid=\"CR27\" class=\"CitationRef\"\u003e27\u003c/span\u003e, \u003cspan citationid=\"CR28\" class=\"CitationRef\"\u003e28\u003c/span\u003e]. The synthesis of tetrazolopyrimidines, particularly those derived from 5-aminotetrazole, has garnered attention due to the challenges associated with traditional methods, which often involve lengthy reaction times, the use of harmful solvents, and multistep processes[\u003cspan citationid=\"CR29\" class=\"CitationRef\"\u003e29\u003c/span\u003e]. Recent advancements have focused on developing more efficient, eco-friendly synthetic routes [\u003cspan citationid=\"CR30\" class=\"CitationRef\"\u003e30\u003c/span\u003e].\u003c/p\u003e \u003cp\u003eConsequently, in continuation to our recent efforts for the heterogenization of BAILs, herein, we aim to decorate on the surface of Fe\u003csub\u003e3\u003c/sub\u003eO\u003csub\u003e4\u003c/sub\u003e@PEG-SO\u003csub\u003e3\u003c/sub\u003eH as novel solid acid catalyst for the efficient synthesis of tetrazolopyrimidines via multicomponent reaction of 5-aminotetrazole, aryl aldehydes and active methylene compounds. The objective of this study is to explore the development and application of supported BAIL (SBAILs) as efficient catalytic systems. By anchoring BAIL onto Fe\u003csub\u003e3\u003c/sub\u003eO\u003csub\u003e4\u003c/sub\u003e@PEG-SO\u003csub\u003e3\u003c/sub\u003eH, the resulting nanohybrid combine the advantages of homogeneous catalysis such as high activity and tunability with the ease of separation and reusability typical of heterogeneous catalysts. Immobilization enhances thermal and chemical stability, reduces leaching of active species, and allows for multiple reaction cycles with minimal performance loss. Moreover, the strategic placement of catalytic sites on the support surface can improve accessibility, leading to greater reaction efficiency and selectivity.\u003c/p\u003e"},{"header":"Results and Discussion","content":"\u003cp\u003e\u003cstrong\u003e2.1 Preparation of the BAIL anchored on Fe\u003csub\u003e3\u003c/sub\u003eO\u003csub\u003e4\u003c/sub\u003e@PEG-SO\u003csub\u003e3\u003c/sub\u003eH support\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe preparation of targeted heterogenous BAIL supported on Fe\u003csub\u003e3\u003c/sub\u003eO\u003csub\u003e4\u003c/sub\u003e@PEG-SO\u003csub\u003e3\u003c/sub\u003eH involves three steps. At the first, N-methylimidazole was reacted with 1,4-butane sultone under solvent free conditions at 60 ℃ to give desired organic 1-methyl,3-butyl sulfonate imidazolium salt (MImBS, Scheme 1). The spectral data (FTIR, \u003csup\u003e1\u003c/sup\u003eH and \u003csup\u003e13\u003c/sup\u003eC NMR spectra) of the synthesized organic zwitterion were compared with those reported in our previous study of this salt [4].\u003c/p\u003e\n\u003cp\u003eIn the next step, Fe\u003csub\u003e3\u003c/sub\u003eO\u003csub\u003e4\u003c/sub\u003e@PEG-SO\u003csub\u003e3\u003c/sub\u003eH support was prepared according to the previous report with some extra modifications. PEG400\u0026nbsp;was added to Fe\u003csub\u003e3\u003c/sub\u003eO\u003csub\u003e4\u003c/sub\u003e nanoparticles in water and the mixture solution was mechanically stirred for 24 h at room temperature. After completion of the reaction, the Fe\u003csub\u003e3\u003c/sub\u003eO\u003csub\u003e4\u003c/sub\u003e@PEG400 nanoparticles were isolated with a magnet and washed with deionized water and anhydrous ethanol and dried. Lastly, Fe\u003csub\u003e3\u003c/sub\u003eO\u003csub\u003e4\u003c/sub\u003e@PEG400 was sulfonated using chlorosulfonic acid (ClSO\u003csub\u003e3\u003c/sub\u003eH) to furnish Fe\u003csub\u003e3\u003c/sub\u003eO\u003csub\u003e4\u003c/sub\u003e@PEG-SO\u003csub\u003e3\u003c/sub\u003eH (Scheme 2). The final step of decoration of MImBS on the surface of Fe\u003csub\u003e3\u003c/sub\u003eO\u003csub\u003e4\u003c/sub\u003e@PEG-SO\u003csub\u003e3\u003c/sub\u003eH support, MImBS and Fe\u003csub\u003e3\u003c/sub\u003eO\u003csub\u003e4\u003c/sub\u003e@PEG-SO\u003csub\u003e3\u003c/sub\u003eH were mixed in ethanol and the reaction was followed under reflux condition to complete proton transferring process from support to MImBS salt which was named as Fe\u003csub\u003e3\u003c/sub\u003eO\u003csub\u003e4\u003c/sub\u003e@PEG-SO\u003csub\u003e3\u003c/sub\u003eH@BAIL (Scheme 2).\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003e2.2 Characterization of the novel nano Fe\u003csub\u003e3\u003c/sub\u003eO\u003csub\u003e4\u003c/sub\u003e@PEG-SO\u003csub\u003e3\u003c/sub\u003eH@BAIL\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eAfter non-covalent ion-pair anchoring BAIL on the surface of nano magnetic organic-inorganic hybrid support, several characterization techniques such as \u003csup\u003e1\u003c/sup\u003eH and \u003csup\u003e13\u003c/sup\u003eC NMR, FT-IR, SEM, TEM, BET, XRD and EDX were used to approve its successful fabrication.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003e2.2.1 FTIR\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eFTIR spectroscopy was utilized to confirm the existence of the main functional groups in synthesized acidic nanohybrid catalyst (\u003cstrong\u003eFig. 1\u003c/strong\u003e). The FTIR spectrum of finalized Fe\u003csub\u003e3\u003c/sub\u003eO\u003csub\u003e4\u003c/sub\u003e@PEG-SO\u003csub\u003e3\u003c/sub\u003eH@BAIL shows almost all vibrations peaks related to the main functional groups included in its structure. As illustrated in Fig. 1c, a peak at 597 cm\u003csup\u003e\u0026minus;1\u003c/sup\u003e is attributed to the Fe\u0026ndash;O\u0026ndash;Fe stretching vibration. Moreover, a broad O\u0026ndash;H stretch around 3432 cm\u003csup\u003e\u0026minus;1\u003c/sup\u003e is observed. The bands at 2931 and 2869 cm\u003csup\u003e\u0026minus;1\u003c/sup\u003e correspond to the aliphatic C\u0026ndash;H stretching vibrations, indicating successful PEG functionalization on the Fe\u003csub\u003e3\u003c/sub\u003eO\u003csub\u003e4\u003c/sub\u003e nanoparticle surface. Furthermore, aromatic C\u0026ndash;H stretching vibrations are existed at 3097 and 3147 cm\u003csup\u003e\u0026minus;1\u003c/sup\u003e that are clear and strong proof for successful decorating of MImBS zwitterion on the surface of Fe\u003csub\u003e3\u003c/sub\u003eO\u003csub\u003e4\u003c/sub\u003e@PEG-SO\u003csub\u003e3\u003c/sub\u003eH support. Additionally, typical absorption peaks at 1184, 1049 cm\u003csup\u003e-1\u0026nbsp;\u003c/sup\u003eare denoted to asymmetric and symmetric stretching vibrations of the sulfonate group respectively. The stretching vibrations of C=N from the imidazolium is observed at 1569 cm\u003csup\u003e\u0026minus;1\u003c/sup\u003e which is another evidence for non-covalent anchoring of MImBS on the surface of the support.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003e2.2.2 SEM, TEM\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe FE-SEM image of\u0026nbsp;Fe\u003csub\u003e3\u003c/sub\u003eO\u003csub\u003e4\u003c/sub\u003e@PEG-SO\u003csub\u003e3\u003c/sub\u003eH@BAIL\u0026nbsp;revealed that the nanoparticles of the prepared hybrid catalyst have almost spherical shape and morphology. Moreover, some aggregation of Fe\u003csub\u003e3\u003c/sub\u003eO\u003csub\u003e4\u003c/sub\u003e MNP was observed (\u003cstrong\u003eFig. 2\u003c/strong\u003e). The TEM image of decorated BAIL on Fe\u003csub\u003e3\u003c/sub\u003eO\u003csub\u003e4\u003c/sub\u003e@PEG-SO\u003csub\u003e3\u003c/sub\u003eH support confirmed the existence of a two-phase system in which an organic layer shell is coated on the surface of Fe\u003csub\u003e3\u003c/sub\u003eO\u003csub\u003e4\u003c/sub\u003e. Moreover, partial aggregation of Fe\u003csub\u003e3\u003c/sub\u003eO\u003csub\u003e4\u0026nbsp;\u003c/sub\u003eMNP is also observable in TEM image (\u003cstrong\u003eFig. 3\u003c/strong\u003e).\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003e2.2.3 BET analysis\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eBET surface area analysis revealed a progressive decrease in porosity upon successive functionalization steps. The bare Fe\u003csub\u003e3\u003c/sub\u003eO\u003csub\u003e4\u0026nbsp;\u003c/sub\u003enanoparticles exhibited a specific surface area of 120 m\u003csup\u003e2\u003c/sup\u003e/g. Following surface modification with PEG-SO\u003csub\u003e3\u003c/sub\u003eH and immobilization of the BAIL (Fe\u003csub\u003e3\u003c/sub\u003eO\u003csub\u003e4\u003c/sub\u003e@PEG-SO\u003csub\u003e3\u003c/sub\u003eH@BAIL), the surface area decreased to 92 m\u003csup\u003e2\u003c/sup\u003e/g, and further dropped to 78 m\u003csup\u003e2\u003c/sup\u003e/g after grafting of the BAIL moiety. This trend is consistent with effective tethering of organic functionalities onto the magnetic core, resulting in partial pore blockage or increased surface coverage. Such a systematic reduction in surface area provides strong support for the formation of a structurally intact, covalently anchored catalytic system.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003e2.2.4 XRD and EDX\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe successful preparation of Fe\u003csub\u003e3\u003c/sub\u003eO\u003csub\u003e4\u003c/sub\u003e@PEG-SO\u003csub\u003e3\u003c/sub\u003eH@BAIL was also approved by EDX detector coupled with FESEM. The EDX analysis of Fe\u003csub\u003e3\u003c/sub\u003eO\u003csub\u003e4\u003c/sub\u003e@PEG-SO\u003csub\u003e3\u003c/sub\u003eH@BAIL exhibited C, N, O, S, and Fe elements dispersed homogenously in the structure of the prepared catalyst (\u003cstrong\u003eFig. 4\u003c/strong\u003e).\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eThe XRD pattern of the introduced Fe\u003csub\u003e3\u003c/sub\u003eO\u003csub\u003e4\u003c/sub\u003e@PEG-SO\u003csub\u003e3\u003c/sub\u003eH@BAIL is presented in \u003cstrong\u003eFig. 5\u003c/strong\u003e. It was observed that the set of diffraction peaks are associated with magnetic cubic structure of Fe\u003csub\u003e3\u003c/sub\u003eO\u003csub\u003e4\u003c/sub\u003e. However, these diffraction peaks are broader than diffraction peaks of pure crystallin Fe\u003csub\u003e3\u003c/sub\u003eO\u003csub\u003e4\u003c/sub\u003e which raised from the influence of amorphous coated organic phase which is further proof for the existence of core-shell structure in \u0026nbsp; Fe\u003csub\u003e3\u003c/sub\u003eO\u003csub\u003e4\u003c/sub\u003e@PEG-SO\u003csub\u003e3\u003c/sub\u003eH@BAIL hybrid.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003e2.3 Synthesis of tetrazolopyrimidines via catalytic processes in the presence of Fe\u003csub\u003e3\u003c/sub\u003eO\u003csub\u003e4\u003c/sub\u003e@PEG-SO\u003csub\u003e3\u003c/sub\u003eH@BAIL\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe construction of biologically significant tetrazolopyrimidine frameworks was accomplished through a multicomponent reaction (MCR) protocol involving 5-aminotetrazole, aldehydes, and active methylene compounds such as dimedone or ethyl acetoacetate. This transformation was mediated by a novel non-covalently anchored BAIL on Fe3O4@PEG400-SO3H support functioning as a magnetic heterogeneous acid catalyst. To systematically evaluate the catalytic efficiency of the introduced solid organic-inorganic acidic hybrid, the model reaction between benzaldehyde, 5-aminotetrazole, and ethyl acetoacetate was selected.\u003c/p\u003e\n\u003cp\u003eIn line with green chemistry principles, all optimization reactions were conducted under solvent-free conditions to minimize environmental impact and enhance sustainability. Under uncatalyzed conditions, the reaction showed no progress even after extended periods at ambient temperature or under thermal activation (Table 1, entries 1, 2). This observation underscores the necessity of an acidic promoter to facilitate the desired transformation. When conventional homogeneous acid such as sulfuric acid was employed, the target tetrazolopyrimidine derivative was obtained within 1 hour, albeit with moderate yields. These results confirm the pivotal role of proton transfer in activating the substrates and driving the reaction forward. The optimal quantity of the hybrid catalyst Fe\u003csub\u003e3\u003c/sub\u003eO\u003csub\u003e4\u003c/sub\u003e@PEG-SO\u003csub\u003e3\u003c/sub\u003eH@BAIL was established at 10 mmol% (20 mg), ensuring maximum efficiency in the reaction system. Under optimized conditions, the reaction achieved maximal product yield of 93% when conducted at 110\u0026deg;C with the precise catalyst dosage (entry 8). Notably, exceeding the optimal catalyst amount or elevating the reaction temperature failed to produce any significant improvement in either reaction kinetics or product yield (entries 9, 10), indicating that these parameters are already at their efficacy limit for this transformation. This observation underscores the critical balance between catalyst loading, thermal activation, and substrate conversion in achieving optimal synthetic outcomes.\u003c/p\u003e\n\u003cp\u003eNotably, the introduction of the prepared magnetic solid acid catalyst significantly enhanced the reaction efficiency. The tunable acidity and robust structural stability of introduced catalyst, enabled the formation of the desired product with improved yield. The superior performance of this hybrid catalyst can be attributed to its dual functionality, combining the advantages of both organic moieties (e.g., enhanced substrate affinity) and inorganic components (e.g., high surface area and thermal stability). Furthermore, the recyclability and reusability of these catalysts were demonstrated, aligning with the principles of sustainable chemical synthesis.\u003c/p\u003e\n\u003cp\u003eTable 1 Optimization of the reaction parameters for the synthesis of tetrazolopyrimidines catalyzed by novel Fe\u003csub\u003e3\u003c/sub\u003eO\u003csub\u003e4\u003c/sub\u003e@PEG-SO\u003csub\u003e3\u003c/sub\u003eH@BAIL\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg 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\" width=\"835\" height=\"487\"\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe synthetic utility of the reaction was broadened by investigating a one-pot, three-component coupling involving a variety of aromatic aldehydes, active methylene compounds (dimedone or ethyl acetoacetate), and 5-aminotetrazole. These transformations were facilitated by a newly developed organic-inorganic nanohybrid catalyst, Fe\u003csub\u003e3\u003c/sub\u003eO\u003csub\u003e4\u003c/sub\u003e@PEG-SO\u003csub\u003e3\u003c/sub\u003eH@BAIL. The protocol enabled access to two distinct heterocyclic frameworks: methyl-7-aryl-4,7-dihydrotetrazolo[1,5-a]pyrimidine-6-carboxylates (D) and 6,6-dimethyl-9-aryl-5,6,7,9-tetrahydrotetrazolo[5,1-b]quinazolin-8(4H)-ones (E). A detailed summary of the results is provided in Table 2.\u003c/p\u003e\n\u003cp\u003eA diverse array of aromatic aldehydes, featuring both electron-withdrawing and electron-donating functionalities, was employed under standardized conditions. Aldehydes substituted with electron-withdrawing groups displayed markedly enhanced reactivity compared to their electron-rich analogs, reflecting the critical role of electronic effects in substrate activation. Additionally, the formation of 6,6-dimethyl-9-aryl-5,6,7,9-tetrahydrotetrazolo[5,1-b]quinazolin-8(4H)-ones proceeded at a faster rate than the synthesis of methyl-7-aryl-4,7-dihydrotetrazolo[1,5-a]pyrimidine-6-carboxylates, requiring shorter reaction times under identical conditions.\u003c/p\u003e\n\u003cp\u003eTable 3 BAISs catalyzed the preparation of tetrazolopyrimidines\u003c/p\u003e\n\u003ctable border=\"0\" cellspacing=\"0\" cellpadding=\"0\" width=\"539\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 12.2449%;\"\u003e\n \u003cp\u003eProduct\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 25.0464%;\"\u003e\n \u003cp\u003eA\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 17.0686%;\"\u003e\n \u003cp\u003eActive methylene compounds\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 12.2449%;\"\u003e\n \u003cp\u003eT (min)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 14.1002%;\"\u003e\n \u003cp\u003eYield(%)\u003csup\u003ea\u003c/sup\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 19.295%;\"\u003e\n \u003cp\u003eMp(̊C)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 12.2449%;\"\u003e\n \u003cp\u003eD1\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 25.0464%;\"\u003e\n \u003cp\u003eC\u003csub\u003e6\u003c/sub\u003eH\u003csub\u003e5\u003c/sub\u003eCHO\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 17.0686%;\"\u003e\n \u003cp\u003eB\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 12.2449%;\"\u003e\n \u003cp\u003e25\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 14.1002%;\"\u003e\n \u003cp\u003e91\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 19.295%;\"\u003e\n \u003cp\u003e203-205 [31]\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 12.2449%;\"\u003e\n \u003cp\u003eD2\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 25.0464%;\"\u003e\n \u003cp\u003e4-MeOC\u003csub\u003e6\u003c/sub\u003eH\u003csub\u003e4\u003c/sub\u003eCHO\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 17.0686%;\"\u003e\n \u003cp\u003eB\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 12.2449%;\"\u003e\n \u003cp\u003e35\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 14.1002%;\"\u003e\n \u003cp\u003e87\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 19.295%;\"\u003e\n \u003cp\u003e193-195 [32]\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 12.2449%;\"\u003e\n \u003cp\u003eD3\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 25.0464%;\"\u003e\n \u003cp\u003e2,4-DiCl-C\u003csub\u003e6\u003c/sub\u003eH\u003csub\u003e3\u003c/sub\u003eCHO\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 17.0686%;\"\u003e\n \u003cp\u003eB\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 12.2449%;\"\u003e\n \u003cp\u003e20\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 14.1002%;\"\u003e\n \u003cp\u003e90\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 19.295%;\"\u003e\n \u003cp\u003e255-257 [33]\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 12.2449%;\"\u003e\n \u003cp\u003eD4\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 25.0464%;\"\u003e\n \u003cp\u003e2-NO\u003csub\u003e2\u003c/sub\u003eC\u003csub\u003e6\u003c/sub\u003eH\u003csub\u003e4\u003c/sub\u003eCHO\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 17.0686%;\"\u003e\n \u003cp\u003eB\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 12.2449%;\"\u003e\n \u003cp\u003e20\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 14.1002%;\"\u003e\n \u003cp\u003e89\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 19.295%;\"\u003e\n \u003cp\u003e240-242 [32]\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 12.2449%;\"\u003e\n \u003cp\u003eE1\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 25.0464%;\"\u003e\n \u003cp\u003eC\u003csub\u003e6\u003c/sub\u003eH\u003csub\u003e5\u003c/sub\u003eCHO\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 17.0686%;\"\u003e\n \u003cp\u003eC\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 12.2449%;\"\u003e\n \u003cp\u003e15\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 14.1002%;\"\u003e\n \u003cp\u003e88\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 19.295%;\"\u003e\n \u003cp\u003e272-274 [31]\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 12.2449%;\"\u003e\n \u003cp\u003eE2\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 25.0464%;\"\u003e\n \u003cp\u003e4-MeOC\u003csub\u003e6\u003c/sub\u003eH\u003csub\u003e4\u003c/sub\u003eCHO\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 17.0686%;\"\u003e\n \u003cp\u003eC\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 12.2449%;\"\u003e\n \u003cp\u003e20\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 14.1002%;\"\u003e\n \u003cp\u003e91\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 19.295%;\"\u003e\n \u003cp\u003e225-227 [33]\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 12.2449%;\"\u003e\n \u003cp\u003eE3\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 25.0464%;\"\u003e\n \u003cp\u003e2-NO\u003csub\u003e2\u003c/sub\u003eC\u003csub\u003e6\u003c/sub\u003eH\u003csub\u003e4\u003c/sub\u003eCHO\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 17.0686%;\"\u003e\n \u003cp\u003eC\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 12.2449%;\"\u003e\n \u003cp\u003e20\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 14.1002%;\"\u003e\n \u003cp\u003e88\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 19.295%;\"\u003e\n \u003cp\u003e260-262 [32]\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 12.2449%;\"\u003e\n \u003cp\u003eE4\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 25.0464%;\"\u003e\n \u003cp\u003e2,4-DiCl-C\u003csub\u003e6\u003c/sub\u003eH\u003csub\u003e3\u003c/sub\u003eCHO\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 17.0686%;\"\u003e\n \u003cp\u003eC\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 12.2449%;\"\u003e\n \u003cp\u003e15\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 14.1002%;\"\u003e\n \u003cp\u003e92\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 19.295%;\"\u003e\n \u003cp\u003e\u0026gt;270 \u0026nbsp; \u0026nbsp; [33]\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 12.2449%;\"\u003e\n \u003cp\u003eE5\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 25.0464%;\"\u003e\n \u003cp\u003e4-BrC\u003csub\u003e6\u003c/sub\u003eH\u003csub\u003e4\u003c/sub\u003eCHO\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 17.0686%;\"\u003e\n \u003cp\u003eC\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 12.2449%;\"\u003e\n \u003cp\u003e25\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 14.1002%;\"\u003e\n \u003cp\u003e90\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 19.295%;\"\u003e\n \u003cp\u003e247-249 [31]\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp\u003e\u003csup\u003e\u0026nbsp;a\u003c/sup\u003e Isolated Yield\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003e2.4 Recyclability study of the prepared nanohybrid catalyst\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eTo assess the durability and reusability of the fabricated protic IL anchored on Fe\u003csub\u003e3\u003c/sub\u003eO\u003csub\u003e4\u003c/sub\u003e@PEG\u003csub\u003e400\u003c/sub\u003eSO\u003csub\u003e3\u003c/sub\u003eH support, the model reaction from Table 1 was repeated under optimized conditions. The reactions were performed at 110\u0026deg;C in a solvent-free environment using the predetermined optimal catalyst loading. Reaction progress was tracked via thin-layer chromatography (TLC) until completion. Upon cooling the reaction mixture to room temperature, 10 mL of acetone was introduced, and the mixture was stirred for an additional 5 minutes. The heterogeneous catalyst was extracted by an external magnet. The remained suspension was concentrated under reduced pressure, and the resulting crude product was purified by recrystallization from hot ethanol, yielding the desired tetrazolopyrimidine derivative in high purity.\u003c/p\u003e\n\u003cp\u003eThe recovered magnetic catalyst was meticulously washed with acetone to eliminate any residual contaminants and subsequently dried at 80\u0026deg;C in preparation for reuse in subsequent cycles. The stability profile of the catalysts over multiple runs is illustrated in Fig. 9. Remarkably, the yield of the reaction remained nearly constant across six consecutive cycles, with the reaction time consistently maintained at 30 minutes for all tested catalysts. These results demonstrate that the catalytic activity and structural integrity of the three hybrid materials are largely preserved even after four successive applications, highlighting their remarkable robustness and potential for sustainable synthetic processes.\u003c/p\u003e\n\u003cp\u003eA proposed mechanism detailing the catalytic involvement of the green heterogeneous organic-inorganic acidic catalyst in the synthesis of tetrazolopyrimidine derivatives (D and E) is illustrated in Scheme 4. The process initiates with the protonation of the aromatic aldehyde by the acidic functionalities of the acidic nanohybrid catalyst, which enhances its electrophilicity. Concurrently, the active methylene compound undergoes enolization, a transformation facilitated by the catalytic environment provided by the hybrid system.\u003c/p\u003e\n\u003cp\u003eNext, a reaction resembling aldol condensation occurs between the activated aldehyde and the enolized form of the active methylene species. Following this, the nucleophilic addition of 5-aminotetrazole to the Michael acceptor, activated by the catalyst, takes place. This step is succeeded by an intramolecular cyclization, driven by the catalyst\u0026apos;s ability to promote heterocyclic ring formation. Finally, dehydration, mediated by the nanohybrid catalyst, completes the sequence, yielding the desired tetrazolopyrimidine products (D and E).\u003c/p\u003e\n\u003cp\u003eThis mechanistic framework highlights the versatility of the introduced catalyst, which orchestrate multiple steps including activation, condensation, cyclization, and dehydration ensuring the efficient construction of the target heterocyclic frameworks under mild conditions.\u003c/p\u003e"},{"header":"Conclusion","content":"\u003cp\u003eIn this work, we have successfully developed and introduced a cutting-edge Br\u0026oslash;nsted acidic ionic liquid (BAIL) immobilized on Fe₃O₄@PEG-SO₃H nanoparticles as a highly efficient and sustainable catalyst for the synthesis of tetrazolopyrimidines. The synthesis of this hybrid material involved a multi-step process, beginning with the formation of an N-butyl sulfonate zwitterion from N-methylimidazole and 1,4-butanesultone, followed by the preparation of Fe₃O₄@PEG-SO₃H core-shell nanoparticles. The final step integrated the zwitterion onto the nanoparticle surface, resulting in a robust and magnetically recoverable catalyst.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eThe catalytic performance of this novel organic-inorganic nanohybrid was demonstrated through a multicomponent reaction involving aromatic aldehydes, active methylene compounds, and 5-aminotetrazole. Remarkably, the catalyst achieved exceptional yields (85\u0026ndash;95%) in remarkably short reaction times (15\u0026ndash;35 minutes) while requiring only a minimal loading of 5 mmol%. This highlights not only its superior catalytic efficiency but also its ability to streamline synthetic processes, making it an attractive option for both academic and industrial applications.\u003c/p\u003e\n\u003cp\u003eOne of the standout features of this hybrid catalyst is its ease of recovery and remarkable reusability. Through simple magnetic separation, the catalyst could be recovered without significant loss of activity, maintaining high yields over at least four consecutive cycles. This recyclability addresses a critical challenge in modern catalysis by reducing waste and promoting sustainability, aligning perfectly with the principles of green chemistry.\u003c/p\u003e\n\u003cp\u003eOverall, this study underscores the immense potential of organic-inorganic hybrid materials in advancing catalytic methodologies. The combination of high efficiency, operational simplicity, and excellent recyclability makes this novel Fe\u003csub\u003e3\u003c/sub\u003eO\u003csub\u003e4\u003c/sub\u003e@PEG-SO\u003csub\u003e3\u003c/sub\u003eH-supported BAIL catalyst a groundbreaking tool for the synthesis of heterocyclic compounds like tetrazolopyrimidines. Its versatility and eco-friendly design pave the way for broader applications in organic synthesis, offering researchers a powerful and sustainable alternative to traditional catalytic systems. This work not only contributes to the field of catalysis but also sets a benchmark for the future development of advanced hybrid materials in chemical transformations.\u003c/p\u003e"},{"header":"Experimental","content":"\u003cp\u003e3.1 Synthesis of organic zwitterion\u003c/p\u003e\n\u003cp\u003e\u003cem\u003eN\u0026nbsp;\u003c/em\u003e-methylimidazole (15 mmol) and 1,4-butanesultone (17 mmol) mixture was introduced into a round-bottom flask fitted with a magnetic stir bar. The reaction was conducted under a nitrogen blanket at 75 °C with continuous stirring until completion. Upon cooling, the crude product was isolated as a white precipitate via filtration, followed by rigorous purification through sequential washing with diethyl ether and acetone. After drying, the final product, identified as MImBs, was obtained as a white solid in quantitative yield (95%).\u003c/p\u003e\n\u003cp\u003e3.2 Synthesis and Surface Modification of Fe\u003csub\u003e3\u003c/sub\u003eO\u003csub\u003e4\u003c/sub\u003e-Based Magnetic Nanoparticles Fe\u003csub\u003e3\u003c/sub\u003eO\u003csub\u003e4\u003c/sub\u003e@PEG400-SO\u003csub\u003e3\u003c/sub\u003eH\u003c/p\u003e\n\u003cp\u003eThe fabrication of Fe\u003csub\u003e3\u003c/sub\u003eO\u003csub\u003e4\u003c/sub\u003e nanoparticles was accomplished via a controlled precipitation process. A mixture of FeCl\u003csub\u003e2\u003c/sub\u003e·4H\u003csub\u003e2\u003c/sub\u003eO (2 g) and FeCl\u003csub\u003e3\u003c/sub\u003e·6H₂O (5.3 g) was dissolved in 30 mL of degassed water, with the addition of 0.85 mL of concentrated hydrochloric acid. This solution was gradually added to 250 mL of a preheated 1.5 M NaOH solution under continuous agitation and an inert nitrogen atmosphere at 80 °C. The resulting magnetic particles were isolated using a strong magnet, rinsed three times with 200 mL of purified water, and dried at 40 °C.\u003c/p\u003e\n\u003cp\u003eTo improve their stability and compatibility, the Fe\u003csub\u003e3\u003c/sub\u003eO\u003csub\u003e4\u003c/sub\u003e nanoparticles were coated with polyethylene glycol 400 (PEG400). Fe\u003csub\u003e3\u003c/sub\u003eO\u003csub\u003e4\u003c/sub\u003e (1 g) was suspended in 100 mL of water using ultrasonic energy for 20 minutes. PEG400\u0026nbsp;(1 g) was then incorporated, and the system was mechanically agitated for 24 h at ambient temperature. The modified nanoparticles, Fe₃O₄@PEG400, were magnetically extracted, washed with purified water and ethanol, and dried at 40 °C.\u003c/p\u003e\n\u003cp\u003eFurther modification involved the introduction of sulfonic acid groups to impart acidic functionality. A sample of 1 g of Fe\u003csub\u003e3\u003c/sub\u003eO\u003csub\u003e4\u003c/sub\u003e@PEG400\u0026nbsp;was dispersed in 50 mL of anhydrous CH\u003csub\u003e2\u003c/sub\u003eCl\u003csub\u003e2\u003c/sub\u003e using ultrasonication for 20 min. Chlorosulfonic acid (0.4 mL) was added dropwise over 30 min at room temperature, followed by stirring for an additional 5 h to ensure complete functionalization. The resulting material, Fe\u003csub\u003e3\u003c/sub\u003eO\u003csub\u003e4\u003c/sub\u003e@PEG400-SO\u003csub\u003e3\u003c/sub\u003eH, was separated magnetically, thoroughly washed with CH\u003csub\u003e2\u003c/sub\u003eCl\u003csub\u003e2\u003c/sub\u003e and acetone, and dried under ambient conditions (Scheme 2).\u003c/p\u003e\n\u003cp\u003eThe concentration of acidic sites on the Fe\u003csub\u003e3\u003c/sub\u003eO\u003csub\u003e4\u003c/sub\u003e@PEG400-SO\u003csub\u003e3\u003c/sub\u003eH hybrid was determined using a titrimetric approach. A 0.1 g sample was reacted with 10 mL of 0.130 N NaOH for 30 min. After magnetic separation and washing with water, the unreacted NaOH was titrated with 0.337 N HCl in the presence of phenolphthalein as an endpoint indicator. The analysis confirmed an acidic site density of 1.35 mmol g\u003csup\u003e-1\u003c/sup\u003e.\u003c/p\u003e\n\u003cp\u003e3.3 Preparation of Fe\u003csub\u003e3\u003c/sub\u003eO\u003csub\u003e4\u003c/sub\u003e@PEG400-SO\u003csub\u003e3\u003c/sub\u003eH@BAIL\u003c/p\u003e\n\u003cp\u003eA round-bottom flask was charged with Fe\u003csub\u003e3\u003c/sub\u003eO\u003csub\u003e4\u003c/sub\u003e@PEG400-SO\u003csub\u003e3\u003c/sub\u003eH (10 g) and the MImBs zwitterion (12 mmol) in 50 mL of ethanol. The mixture was refluxed under continuous stirring for 12 h to facilitate the incorporation of the zwitterion onto the hybrid material. Following the reaction, the non-covalently anchored BAIL on the magnetic support (Fe\u003csub\u003e3\u003c/sub\u003eO\u003csub\u003e4\u003c/sub\u003e@PEG400-SO\u003csub\u003e3\u003c/sub\u003eH@BAIL)\u0026nbsp;was extracted by a magnet which was then thoroughly washed with water to remove any unbound zwitterionic species. The obtained solid was dried under vacuum at 50 °C for 8 hours to eliminate residual solvents, yielding the final pure organic-inorganic catalytic system.\u003c/p\u003e\n\u003cp\u003e3.4. General procedure for the synthesis of tetrazolopyrimidine derivatives catalyzed by novel introduced Fe\u003csub\u003e3\u003c/sub\u003eO\u003csub\u003e4\u003c/sub\u003e@PEG400-SO\u003csub\u003e3\u003c/sub\u003eH@BAIL\u0026nbsp;organic-inorganic hybrids\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eA reaction mixture consisting of aromatic aldehyde A (1 mmol), active methylene compound B or C (1 mmol), and 5-aminotetrazole (1 mmol) was prepared. To this, an optimized loading of 2 mol% Fe\u003csub\u003e3\u003c/sub\u003eO\u003csub\u003e4\u003c/sub\u003e@PEG400-SO3H@BAIL catalyst was introduced. The temperature was raised to 110 °C, and the mixture was stirred magnetically for a duration determined according to Table 2. Reaction progress was monitored by TLC using n-hexane:ethyl acetate (2:1) as the eluent. Upon completion, the reaction mixture was cooled to room temperature, and 10 mL of acetone was added, followed by stirring for 5 minutes.\u003c/p\u003e\n\u003cp\u003eThe catalyst was then separated using an external magnet, thoroughly washed with acetone, and dried for reuse in subsequent reactions. The remaining solution was concentrated under reduced pressure, and the resulting solid was recrystallized from hot ethanol (2 × 25 mL) to yield the target tetrazolopyrimidine derivative in pure form. All synthesized products were identified as known compounds and characterized using IR and NMR spectroscopy, along with CHN elemental analysis for novel derivatives. Melting points were measured and compared with reported literature values for verification [27, 34, 35].\u003c/p\u003e"},{"header":"Declarations","content":"\u003cp\u003e\u003cstrong\u003eDisclosure of interest:\u0026nbsp;\u003c/strong\u003eThe author reports there are no competing interests to declare\u003c/p\u003e\n\u003ch2\u003eAuthor Contribution\u003c/h2\u003e\u003cp\u003eLayla A. Taib conceptualized and designed the entire study, conducted all experiments, collected and analyzed data, and interpreted the results. She was solely responsible for drafting the manuscript, creating figures, and preparing the final version for submission.\u003c/p\u003e\u003ch2\u003eAcknowledgement\u003c/h2\u003e \u003cp\u003eThe author gratefully acknowledges to the Research Council of King Abdulaziz University for financial support of this work.\u003c/p\u003e"},{"header":"References","content":"\u003col\u003e\n\u003cli\u003eM. Sun, X. Bai, X. Fu, X. Yu, Z. Ye, M. Zhang, Y. Qiu, Modification of Fe3O4 magnetic nanoparticles for antibiotic detection, Scientific Reports, 15 (2025) 4751.\u003c/li\u003e\n\u003cli\u003eN.N. Patel, N.R. Mulla, V.M. Khot, R.S. Patil, Anticancer activity of surface functionalized magnetite (Fe3O4) nanoparticles\u0026mdash;Effect of polymer coating, Emergent Materials, 7 (2024) 1071-1080.\u003c/li\u003e\n\u003cli\u003eM. Cheraghi, B. Karami, M. Farahi, M. Keshavarz, A novel, ecofriendly 1H-1, 2, 4-triazole-3-thiol-functionalized Fe3O4@ SiO2 magnetic nano-catalyst for the synthesis of 2 H-indazolo [2, 1-b] phthalazine-trione and triazolo [1, 2-a] indazole-trione derivatives, Research on Chemical Intermediates, 49 (2023) 1941-1958.\u003c/li\u003e\n\u003cli\u003eM. Keshavarz, L.A. Taib, N. Iravani, Ion-Pair Anchored Protic Ionic Liquids on Magnetic Nano Silica Sulfuric Acid as Efficient Catalysts for Organic Synthesis, Journal of Inorganic and Organometallic Polymers and Materials, 33 (2023) 3247-3258.\u003c/li\u003e\n\u003cli\u003eM.D. Nguyen, H.-V. Tran, S. Xu, T.R. Lee, Fe3O4 nanoparticles: structures, synthesis, magnetic properties, surface functionalization, and emerging applications, Applied Sciences, 11 (2021) 11301.\u003c/li\u003e\n\u003cli\u003eA. Rajan, N.K. Sahu, Hydrophobic-to-hydrophilic transition of Fe3O4 nanorods for magnetically induced hyperthermia, ACS Applied Nano Materials, 4 (2021) 4642-4653.\u003c/li\u003e\n\u003cli\u003eM.A. Mohammadi, S. Asghari, B. Aslibeiki, Surface modified Fe3O4 nanoparticles: a cross-linked polyethylene glycol coating using plasma treatment, Surfaces and Interfaces, 25 (2021) 101271.\u003c/li\u003e\n\u003cli\u003eJ. Guo, Y. Sun, X. Li, S. Xi, M.M. Ibrahim, H. Qiu, G.A. Mersal, Z.M. El-Bahy, V. Murugadoss, W. Abdul, Hollow core-shell structured Fe3O4@ Polypyrrole composites for enhanced electromagnetic wave absorption, Composites Science and Technology, 258 (2024) 110917.\u003c/li\u003e\n\u003cli\u003eS. Mirfakhraei, M. Hekmati, F.H. Eshbala, H. Veisi, Expression of concern: Fe 3 O 4/PEG-SO 3 H as a heterogeneous and magnetically-recyclable nanocatalyst for the oxidation of sulfides to sulfones or sulfoxides, New Journal of Chemistry, 48 (2024) 17361-17361.\u003c/li\u003e\n\u003cli\u003eM. Azizi, A. Maleki, A. Bodaghi, Green synthesis of Poly (ethylene oxide)-coated sulfonated copper ferrite nanoparticles and highly efficient application in the synthesis of dihydropyrimidine derivatives, Nanochemistry Research, 7 (2022) 68-78.\u003c/li\u003e\n\u003cli\u003eY. Pei, Y. Zhang, J. Ma, M. Fan, S. Zhang, J. Wang, Ionic liquids for advanced materials, Materials Today Nano, 17 (2022) 100159.\u003c/li\u003e\n\u003cli\u003eG. Kaur, H. Kumar, M. Singla, Diverse applications of ionic liquids: A comprehensive review, Journal of Molecular Liquids, 351 (2022) 118556.\u003c/li\u003e\n\u003cli\u003eG. Yu, D. Zhao, L. Wen, S. Yang, X. Chen, Viscosity of ionic liquids: Database, observation, and quantitative structure‐property relationship analysis, AIChE Journal, 58 (2012) 2885-2899.\u003c/li\u003e\n\u003cli\u003eF. Arian, M. Keshavarz, H. Sanaeishoar, N. 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Pant, Recent advances in supported ionic liquid catalysts for sustainable biomass valorisation to high-value chemicals and fuels, Chemical Engineering Journal, 450 (2022) 138032.\u003c/li\u003e\n\u003cli\u003eL.A. Taib, M. Keshavarz, M. Panahimehr, Introduction of Click Synthesized Novel Organic-Inorganic Solid Acid Catalysts for Highly Promoted Synthesis of Substituted Xanthenes, Polycyclic Aromatic Compounds, 43 (2023) 2233-2249.\u003c/li\u003e\n\u003cli\u003eL.A. Taib, M. Keshavarz, A. Parhami, Click approach to the novel 1, 2, 3-triazolium phosphotungstate organic\u0026ndash;inorganic hybrids for the highly promoted synthesis of spirooxindoles, Research on Chemical Intermediates, 48 (2022) 795-815.\u003c/li\u003e\n\u003cli\u003eL. Lozano, C. God\u0026iacute;nez, A. De Los Rios, F. Hern\u0026aacute;ndez-Fern\u0026aacute;ndez, S. S\u0026aacute;nchez-Segado, F.J. 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Zhong, Arylformylacetonitriles in multicomponent reactions leading to heterocycles, European Journal of Organic Chemistry, 2022 (2022) e202201038.\u003c/li\u003e\n\u003cli\u003eS. Sharma, M.A. Babu, R. Kumar, T.G. Singh, A.R. Dwivedi, G. Ahmad, K.K. Goel, B. Kumar, A review on pyrimidine-based pharmacophore as a template for the development of hybrid drugs with anticancer potential, Molecular Diversity, (2025) 1-23.\u003c/li\u003e\n\u003cli\u003eR. Natarajan, H.N. Anthoni Samy, A. Sivaperuman, A. Subramani, Structure-activity relationships of pyrimidine derivatives and their biological activity-A review, Medicinal Chemistry, 19 (2023) 10-30.\u003c/li\u003e\n\u003cli\u003eK. Singh, R. Pal, S.A. Khan, B. Kumar, M.J. Akhtar, Insights into the structure activity relationship of nitrogen-containing heterocyclics for the development of antidepressant compounds: An updated review, Journal of Molecular Structure, 1237 (2021) 130369.\u003c/li\u003e\n\u003cli\u003eB. Banerjee, A. Sharma, A. Singh, M. Kaur, A. Priya, Synthesis of Isatin-derived Heterocycles with Promising Anticancer Activities, Current Topics in Medicinal Chemistry, 25 (2025) 96-123.\u003c/li\u003e\n\u003cli\u003eS. Leyva-Ramos, J. Cardoso-Ortiz, Recent developments in the synthesis of tetrazoles and their pharmacological relevance, Current Organic Chemistry, 25 (2021) 388-403.\u003c/li\u003e\n\u003cli\u003eN. Jangir, Poonam, S. Dhadda, D.K. Jangid, Recent advances in the synthesis of five‐and six‐membered heterocycles as bioactive skeleton: A concise overview, ChemistrySelect, 7 (2022) e202103139.\u003c/li\u003e\n\u003cli\u003eL.-Y. Zeng, C. Cai, Iodine catalyzed one-pot multicomponent synthesis of a library of compounds containing tetrazolo [1, 5-a] pyrimidine core, Journal of Combinatorial Chemistry, 12 (2010) 35-40.\u003c/li\u003e\n\u003cli\u003eL.A. Taib, M. Keshavarz, Non-covalent immobilized sultone based protic ionic liquids on nano silica sulfuric acid as novel heterogeneous catalysts for the efficient synthesis of tetrazolopyrimidines, Journal of Porous Materials, (2022).\u003c/li\u003e\n\u003cli\u003eA. Hassankhani, B. Gholipour, S. Rostamnia, An efficient regioselective three-component synthesis of tetrazoloquinazolines using g-C3N4 covalently bonded sulfamic acid, Polyhedron, 175 (2020) 114217.\u003c/li\u003e\n\u003c/ol\u003e"},{"header":"Schemes","content":"\u003cp\u003eSchemes 1 to 4 are available in the Supplementary Files section.\u003c/p\u003e"}],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":true,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":true,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":false,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":false,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"Core-Shell, Heterogenous, Organic-Inorganic, Sultone, Brønsted Acidic Ionic Liquid, Green Chemistry, tetrazolopyrimidines","lastPublishedDoi":"10.21203/rs.3.rs-6793365/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-6793365/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003eA robust and sustainable catalytic system was developed by immobilizing a Br\u0026oslash;nsted acidic ionic liquid (BAIL) onto Fe\u003csub\u003e3\u003c/sub\u003eO\u003csub\u003e4\u003c/sub\u003e@PEG-SO₃H nanoparticles for the efficient synthesis of tetrazolopyrimidine derivatives. The fabrication of the catalyst commenced with the formation of an N-butyl sulfonate zwitterion via the reaction of N-methylimidazole with 1,4-butanesultone. Subsequently, Fe\u003csub\u003e3\u003c/sub\u003eO\u003csub\u003e4\u003c/sub\u003e@PEG-SO₃H core-shell nanoparticles were synthesized and functionalized by anchoring the zwitterion onto their surface through a reflux-assisted grafting process in ethanol. The resulting hybrid material was meticulously characterized using advanced analytical techniques, including FTIR, \u0026sup1;H NMR, XRD, SEM, TEM, BET and EDX confirming its structural integrity, thermal stability, and magnetic properties.\u003c/p\u003e \u003cp\u003eThe catalytic efficacy of the hybrid was demonstrated in a one-pot multicomponent reaction involving aromatic aldehydes, active methylene compounds, and 5-aminotetrazole. Under optimized conditions, the catalyst exhibited exceptional performance, delivering high yields (85\u0026ndash;95%) within remarkably short reaction times (15\u0026ndash;35 minutes) at a minimal loading of 5 mol%. Furthermore, the catalyst's magnetic properties facilitated facile recovery, while its remarkable reusability was evidenced by sustained activity over four consecutive cycles with negligible loss in yield. Moreover, the introduced anchored BAIL combines the advantages of both heterogeneous and homogeneous catalysis while overcoming the limitations associated with free BAIL\u003c/p\u003e","manuscriptTitle":"Acidic Ionic Liquid Anchored on PEG-Decorated Fe3O4 Nanoparticles: A Novel Heterogeneous and Magnetically Recoverable Organic-Inorganic Catalyst for the Efficient Synthesis of Pyrimidine Derivatives\nRunning head: Magnetic nanohybrid acidic catalyst","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2025-06-12 08:29:26","doi":"10.21203/rs.3.rs-6793365/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"c8b80ed0-2805-414f-8a5e-ecab4f7dfbc0","owner":[],"postedDate":"June 12th, 2025","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[],"tags":[],"updatedAt":"2025-07-17T08:54:12+00:00","versionOfRecord":[],"versionCreatedAt":"2025-06-12 08:29:26","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-6793365","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-6793365","identity":"rs-6793365","version":["v1"]},"buildId":"8U1c8b4HqxoKbykW_rLl7","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}