A Comprehensive Clinical Evaluation of Levocetirizine in the Treatment of Chronic Urticaria in Children

A Comprehensive Clinical Evaluation of Levocetirizine in the Treatment of Chronic Urticaria in Children | Authorea try { document.documentElement.classList.add('js'); } catch (e) { } var _gaq = _gaq || []; _gaq.push(['_setAccount', 'G-8VDV14Y67G']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 'https://ssl' : 'http://www') + '.google-analytics.com/ga.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s); })(); Skip to main content Preprints Collections Wiley Open Research IET Open Research Ecological Society of Japan All Collections About About Authorea FAQs Contact Us Quick Search anywhere Search for preprint articles, keywords, etc. Search Search ADVANCED SEARCH SCROLL This is a preprint and has not been peer reviewed. Data may be preliminary. 11 April 2025 V1 Latest version Share on A Comprehensive Clinical Evaluation of Levocetirizine in the Treatment of Chronic Urticaria in Children Authors : Lu Liu , Chang Liu , and Meixing Yan [email protected] Authors Info & Affiliations https://doi.org/10.22541/au.174435861.13776067/v1 Published Frontiers in Pharmacology Version of record Peer review timeline 164 views 79 downloads Contents Abstract Supplementary Material Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Background Levocetirizine is a second-generation antihistamine that is the first-line drug recommended by the guidelines for the treatment of chronic urticaria in children. However, the current study focused mainly on adults, and a comprehensive evaluation of children has not been reported. Therefore, comprehensive clinical evaluation of levocetirizine in the treatment of chronic urticaria in children is crucial for providing rational clinical drug use and improving the basis of relevant national policies.To conduct a comprehensive clinical evaluation of levocetirizine in the treatment of chronic urticaria in children and provide a reference for rational drug use and related policy decisions in clinical practice. Methods A comprehensive evaluation index system for the use of antiallergic drugs in children was established via a literature review, expert interviews, and the Delphi method. Evidence was collected to evaluate the safety, effectiveness, economy, suitability, accessibility and innovation of levocetirizine and loratadine for the treatment of chronic urticaria in children. Results The comprehensive clinical evaluation index system included 6 primary indicators, 12 secondary indicators, and 25 tertiary indicators. The total clinical comprehensive evaluation score of levocetirizine was 92.83, whereas that of loratadine was 72.49. The former is superior to the latter in terms of safety, effectiveness, suitability, innovation, and accessibility, whereas the latter is more cost-effective than the former. Conclusions The comprehensive clinical value of levocetirizine is greater than that of loratadine in the treatment of chronic urticaria in children, which can provide evidence for the rational use of antiallergic drugs and drug catalog selection in medical institutions. Supplementary Material File (manuscript.docx) Download 40.14 KB Information & Authors Information Version history V1 Version 1 11 April 2025 Peer review timeline Published Frontiers in Pharmacology Version of Record 31 Jul 2025 Published Copyright This work is licensed under a Non Exclusive No Reuse License. Authors Affiliations Lu Liu Qingdao Women and Children's Hospital View all articles by this author Chang Liu Qingdao Women and Children's Hospital View all articles by this author Meixing Yan [email protected] Qingdao Women and Children's Hospital View all articles by this author Metrics & Citations Metrics Article Usage 164 views 79 downloads .FvxKWukQNSOunydq8rnd { width: 100px; } Citations Download citation Lu Liu, Chang Liu, Meixing Yan. A Comprehensive Clinical Evaluation of Levocetirizine in the Treatment of Chronic Urticaria in Children. Authorea . 11 April 2025. DOI: https://doi.org/10.22541/au.174435861.13776067/v1 If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download. For more information or tips please see 'Downloading to a citation manager' in the Help menu . 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