Adenoid Cystic Carcinoma of the Breast: A Case Report

Adenoid Cystic Carcinoma of the Breast: A Case Report | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Case Report Adenoid Cystic Carcinoma of the Breast: A Case Report Jose Hercules This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-4104201/v4 This work is licensed under a CC BY 4.0 License Status: Posted Version 4 posted You are reading this latest preprint version Show more versions Abstract Adenoid cystic carcinoma is a rare form of breast cancer accounting for 0.1%-1.0% of all mammary cancer malignancies. Breast cancer is characterized by an indolent clinical course and favorable prognosis, contrary to other breast cancers. Diagnostic mammogram and breast ultrasound play a pivotal role in the early detection and diagnosis of breast adenoid cystic carcinoma. Treatment may consist of lumpectomy and radiation therapy vs mastectomy alone. Although rare, late disease recurrence and metastasis have been reported in the literature; thus, long-term surveillance is of utmost importance for these patients. We will review the literature and discuss the case of a 52-year-old female who presented with a palpable lump of the right breast, which was pathologically proven to be adenoid cystic carcinoma of the breast. Pathology adenoid cystic carcinoma CD117 Figures Figure 1 Introduction Primary adenoid cystic carcinoma (ACC) of the breast is rarely observed clinically. It is a special subtype of triple-negative breast cancer characterized by low expression of Ki-67, low malignant potential, slow progression and favorable prognosis. To date, treatment for this disease is controversial, and no consensus has been reached. Case presentation The patient is a 62-year-old African American female with no personal or family history of breast cancer who presented to our facility with a palpable nonpainful lump in the right breast. Diagnostic mammogram images demonstrated an approximately 1.0 cm obscured mass in the upper outer right breast at the 10:00 position, corresponding to the site of the palpable abnormality. Ultrasound revealed an irregular, nonparallel, solid, hypoechoic mass with microlobulated margins, an echogenic rim, posterior acoustic shadowing, and peripheral vascularity. There was no abnormal axillary lymph nodes. Given the suspicious features, the final assessment of the diagnostic mammogram and ultrasound was a BIRADS-4, and recommendations were given for tissue diagnosis with ultrasound-guided core biopsy. Biopsy was performed with five passes with a 12-gauge Celero vacuum-assisted device under ultrasound guidance. Pathology revealed adenoid cystic carcinoma of the breast. Histologic examination revealed an isolated nodule of the ACC with small to medium cells with basaloid features arranged in cribriform and tubular patterns. Immunohistochemically, the luminal tumor cells were diffusely positive for CD117 and CK7, and the myoepithelial cells were positive for p63 (Figure 1). The tumor was triple negative for estrogen receptor (ER), progesterone receptor (PR), and human epidermal receptor 2 (HER2). Discussion Salivary gland tumors of the lung is rare, and the most common types are mucoepidermoid carcinoma and adenoid cystic carcinoma. In past reports, ACC of the breast occurred in patients between the ages of 25 and 86 years, with a disproportionate number occurring in comparatively elderly women. The most common area of onset is subareolar and in the vicinity of the areola (approx. 50%), and the tumor often appears as a spherical, mobile mass under palpation. The ACC of the breast does not favor the left or right side and tends not to occur bilaterally, and breast pain at the tumor site is a characteristic clinical symptom in approximately 14% of patients. This type of breast pain is speculated to involve perineural infiltration of tumor cells and contraction of myoepithelial cells. ACC of the breast has no characteristic imaging findings and often appears as a sharply marginated shadow on mammography and ultrasonography. In our patient, a palpable mass without pain was found in the vicinity of the areola. ACC is a biphasic tumor composed of ductal and myoepithelial cells. Myoepithelial cells have dark angled nuclei and scant cytoplasm, resulting in a basaloid appearance. ACC demonstrates three main histological growth patterns, the most common being the cribriform pattern, followed by the tubular pattern. The least frequent and most aggressive pattern is the solid pattern, which is more often associated with lymph node and distant metastasis. The tubular pattern consists of simple tubules lined by inner ductal and outer myoepithelial cells, and the cribriform pattern is composed predominantly of myoepithelial cells with myxoid or hyalinized globules. The solid patterns have solid nests composed of sheets of basaloid cells. Lymphovascular invasion and lymph node metastasis are uncommon, while perineural invasion is extremely frequent. High-grade transformation is observed in a small number of patients and is associated with a high risk of lymph node metastasis, distant metastasis and disease-related death. Focal squamous metaplasia and differentiation can be observed in patients with high-grade transformation. Immunohistochemically, ductal or luminal cells are positive for CK7, CAM5.2, and CD117, and myoepithelial cells express smooth muscle actin (SMA), S100, calponin, P63, P40, and GFAP. MYB overexpression is a sensitive but nonspecific immunomarker for adenoid cystic carcinoma and is a nuclear marker that is preferentially expressed in myoepithelial cells. Surgery is now recognized as the primary treatment for breast ACC patients. However, due to the rarity of this pathological type, there is no clear guarantee in the selection of a detailed surgical method for this disease, resulting in differences in treatment. Ro et al. suggested that the operation method should be selected according to the ACC grade. Tumor lumpectomy should be used for Grade I tumors, mastectomy should be used for Grade II tumors, and mastectomy plus lymph node dissection should be used for Grade III tumors. Here, we will discuss the operation methods for classic breast ACC and SBACC. A clinical study of 478 patients with classic breast ACC reported that relapse occurred after local excision. The treatments included tumor lumpectomy plus adjuvant RT, tumor lumpectomy alone, mastectomy alone and mastectomy plus adjuvant RT. K–M analysis revealed that patients receiving tumor lumpectomy plus adjuvant RT had better survival than patients receiving other treatments, indicating that lumpectomy plus adjuvant RT can improve survival and that BCS is a reasonable choice for breast ACC patients. In conclusion, our results show that the majority of ACCs were triple-negative, but our study also included a small number of hormone receptor-positive breast cancers. Compared with other types of breast cancer, ACC has no specificity for imaging, and FNAC may be a useful tool for diagnosis. The final diagnosis can only be assessed based on the results of histopathological and immunohistochemical examinations. Declarations All co-authors have seen and agree with the contents of the manuscript and there is no financial interest to report. Consent was given by the patient for publication and research purposes References Zhang, Meilin, et al. "Breast adenoid cystic carcinoma: a report of seven cases and literature review." BMC surgery 22.1 (2022): 113.‏ Glazebrook, Katrina N., et al. "Adenoid cystic carcinoma of the breast." American Journal of Roentgenology 194.5 (2010): 1391-1396.‏ Claudia Gordillo, Anjeza Chukus,Adenoid cystic carcinoma: A case of rare breast cancer,Radiology Case Reports,Volume 17, Issue 3,2022,Pages 690-692,ISSN 1930- Ghabach, Bassam, et al. "Adenoid cystic carcinoma of the breast in the United States (1977 to 2006): a population-based cohort study." Breast Cancer Research 12 (2010): 1-9.‏ Khanfir, Kaouthar, et al. "Management of adenoid cystic carcinoma of the breast: a Rare Cancer Network study." International Journal of Radiation Oncology* Biology* Physics 82.5 (2012): 2118-2124.‏ Ro, Jae Y., Elvio G. Silva, and H. Stephen Gallager. "Adenoid cystic carcinoma of the breast." Human pathology 18.12 (1987): 1276-1281.‏ Lakhani, Sunil R., et al. "WHO Classification of Tumors of the Breast." (2012).‏ Miyai K, Schwartz MR, Divatia MK, Anton RC, Park YW, Ayala AG, Ro JY. Adenoid cystic carcinoma of breast: Recent advances. World J Clin Cases. 2014 Dec 16;2(12):732-41. doi: 10.12998/wjcc.v2.i12.732. PMID: 25516849; PMCID: PMC4266822. Grabenstetter, A., Brogi, E., Zhang, H. et al. Solid-basaloid variant of adenoid cystic carcinoma of the breast with near complete response to neoadjuvant chemotherapy. npj Breast Cancer 8 , 93 (2022). https://doi.org/10.1038/s41523-022-00469-z Li, L.; Zhang, D.; Ma, F. Adenoid Cystic Carcinoma of the Breast May Be Exempt from Adjuvant Chemotherapy. J. Clin. Med. 2022 , 11 , 4477. https://doi.org/10.3390/jcm11154477 Leeming R, Jenkins M, Mendelsohn G. Adenoid Cystic Carcinoma of the Breast. Arch Surg. 1992;127(2):233–235. doi:10.1001/archsurg.1992.01420020127019 Bendari, Ahmed, et al. "Primary adenoid cystic carcinoma in the lung: Reporting two cases and mini-literature review." Human Pathology Reports 35 (2024): 300727. ‏ Kleer, Celina G. M.D.; Oberman, Harold A. M.D.. Adenoid Cystic Carcinoma of the Breast: Value of Histologic Grading and Proliferative Activity. The American Journal of Surgical Pathology 22(5):p 569-575, May 1998. Bendari, Ahmed, et al. "Papillary Thyroid Carcinoma With Lymphoepithelial Features and Lacking Association With Epstein-Barr Virus (EBV): A Rare Case." Cureus 16.2 (2024). ‏ Additional Declarations The authors declare no competing interests. Cite Share Download PDF Status: Posted Version 4 posted You are reading this latest preprint version Show more versions Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-4104201","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Case Report","associatedPublications":[],"authors":[{"id":292066645,"identity":"a93939dd-bfd0-4f2e-bb10-0d9b0bb603cd","order_by":0,"name":"Jose Hercules","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAA9klEQVRIiWNgGAWjYBACxhlgyoKBQf7wgQMfgEw2duK0SAARW+JDEIeNmZA1EnAtPMbGPCA2IS3Ms5uPffjZJiEnP7vHTNrm1zZ5PmYGxg8fc/A4bM6x5Jm9bRLGBneOlUnn9t02bGNmYJacuQ2fX3KMmRnbJBI3MCRvk87tuc0I1MLGzItXS/5nkJb6+Q0JZtKWPbftidCSwwzSksBwI8XYmOHH7UQitKQZM/ackzDccOZY4sPehtvJbcyMzXj9Yjgj+THDjzIbefn25gMHfvy5bTu/vfngh4/4tDSg2NkGJhuwqYQDeVTuH7yKR8EoGAWjYIQCAGnST27N/cTDAAAAAElFTkSuQmCC","orcid":"","institution":"Fundación Valle del Lili","correspondingAuthor":true,"prefix":"","firstName":"Jose","middleName":"","lastName":"Hercules","suffix":""}],"badges":[],"createdAt":"2024-03-15 02:25:57","currentVersionCode":4,"declarations":{"humanSubjects":true,"vertebrateSubjects":false,"conflictsOfInterestStatement":false,"humanSubjectEthicalGuidelines":true,"humanSubjectConsent":true,"humanSubjectClinicalTrial":false,"humanSubjectCaseReport":true,"vertebrateSubjectEthicalGuidelines":false},"doi":"10.21203/rs.3.rs-4104201/v4","doiUrl":"https://doi.org/10.21203/rs.3.rs-4104201/v4","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":60607544,"identity":"800a63b7-ff04-4657-a316-e8dabff60400","added_by":"auto","created_at":"2024-07-18 17:26:36","extension":"jpg","order_by":1,"title":"Figure 1","display":"","copyAsset":false,"role":"figure","size":180313,"visible":true,"origin":"","legend":"\u003cp\u003e(A-4X): Core biopsy shows cribriforma and tubular pattern of adenoid cystic carcinoma. (B-4X): CD117 positive in the tumor cells. (C-10X):CK7 positive in luminal cells. (D-4X): P63 positive in basal cells.\u003c/p\u003e","description":"","filename":"FIGUREACCBREAST.jpg","url":"https://assets-eu.researchsquare.com/files/rs-4104201/v4/692d03301b34947358eb7e2e.jpg"},{"id":60607545,"identity":"db80e834-87c0-4a6a-a412-17aaa8b5f956","added_by":"auto","created_at":"2024-07-18 17:26:40","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":330580,"visible":true,"origin":"","legend":"","description":"","filename":"manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-4104201/v4/1ae90a68-e37c-474e-a992-c297db7ebf0b.pdf"}],"financialInterests":"The authors declare no competing interests.","formattedTitle":"Adenoid Cystic Carcinoma of the Breast: A Case Report","fulltext":[{"header":"Introduction","content":"\u003cp\u003ePrimary adenoid cystic carcinoma (ACC) of the breast is rarely observed clinically. It is a special subtype of triple-negative breast cancer characterized by low expression of Ki-67, low malignant potential, slow progression and favorable prognosis. To date, treatment for this disease is controversial, and no consensus has been reached.\u003c/p\u003e"},{"header":"Case presentation","content":"\u003cp\u003eThe patient is a 62-year-old African American female with no personal or family history of breast cancer who presented to our facility with a palpable nonpainful lump in the right breast. Diagnostic mammogram images demonstrated an approximately 1.0 cm obscured mass in the upper outer right breast at the 10:00 position, corresponding to the site of the palpable abnormality. Ultrasound revealed an irregular, nonparallel, solid, hypoechoic mass with microlobulated margins, an echogenic rim, posterior acoustic shadowing, and peripheral vascularity. There was no abnormal axillary lymph nodes. Given the suspicious features, the final assessment of the diagnostic mammogram and ultrasound was a BIRADS-4, and recommendations were given for tissue diagnosis with ultrasound-guided core biopsy. Biopsy was performed with five passes with a 12-gauge Celero vacuum-assisted device under ultrasound guidance. Pathology revealed adenoid cystic carcinoma of the breast. Histologic examination revealed an isolated nodule of the ACC with small to medium cells with basaloid features arranged in cribriform and tubular patterns. Immunohistochemically, the luminal tumor cells were diffusely positive for CD117 and CK7, and the myoepithelial cells were positive for p63 (Figure 1). The tumor was triple negative for estrogen receptor (ER), progesterone receptor (PR), and human epidermal receptor 2 (HER2).\u003c/p\u003e"},{"header":"Discussion","content":"\u003cp\u003eSalivary gland tumors of the lung is rare, and the most common types are mucoepidermoid carcinoma and adenoid cystic carcinoma. In past reports, ACC of the breast occurred in patients between the ages of 25 and 86 years, with a disproportionate number occurring in comparatively elderly women. The most common area of onset is subareolar and in the vicinity of the areola (approx. 50%), and the tumor often appears as a spherical, mobile mass under palpation. The ACC of the breast does not favor the left or right side and tends not to occur bilaterally, and breast pain at the tumor site is a characteristic clinical symptom in approximately 14% of patients. This type of breast pain is speculated to involve perineural infiltration of tumor cells and contraction of myoepithelial cells. ACC of the breast has no characteristic imaging findings and often appears as a sharply marginated shadow on mammography and ultrasonography. In our patient, a palpable mass without pain was found in the vicinity of the areola. ACC is a biphasic tumor composed of ductal and myoepithelial cells. Myoepithelial cells have dark angled nuclei and scant cytoplasm, resulting in a basaloid appearance. ACC demonstrates three main histological growth patterns, the most common being the cribriform pattern, followed by the tubular pattern. The least frequent and most aggressive pattern is the solid pattern, which is more often associated with lymph node and distant metastasis. The tubular pattern consists of simple tubules lined by inner ductal and outer myoepithelial cells, and the cribriform pattern is composed predominantly of myoepithelial cells with myxoid or hyalinized globules. The solid patterns have solid nests composed of sheets of basaloid cells. Lymphovascular invasion and lymph node metastasis are uncommon, while perineural invasion is extremely frequent. High-grade transformation is observed in a small number of patients and is associated with a high risk of lymph node metastasis, distant metastasis and disease-related death. Focal squamous metaplasia and differentiation can be observed in patients with high-grade transformation. Immunohistochemically, ductal or luminal cells are positive for CK7, CAM5.2, and CD117, and myoepithelial cells express smooth muscle actin (SMA), S100, calponin, P63, P40, and GFAP. MYB overexpression is a sensitive but nonspecific immunomarker for adenoid cystic carcinoma and is a nuclear marker that is preferentially expressed in myoepithelial cells.\u003c/p\u003e\n\u003cp\u003eSurgery is now recognized as the primary treatment for breast ACC patients. However, due to the rarity of this pathological type, there is no clear guarantee in the selection of a detailed surgical method for this disease, resulting in differences in treatment. Ro et al. suggested that the operation method should be selected according to the ACC grade. Tumor lumpectomy should be used for Grade I tumors, mastectomy should be used for Grade II tumors, and mastectomy plus lymph node dissection should be used for Grade III tumors. Here, we will discuss the operation methods for classic breast ACC and SBACC.\u003c/p\u003e\n\u003cp\u003eA clinical study of 478 patients with classic breast ACC reported that relapse occurred after local excision. The treatments included tumor lumpectomy plus adjuvant RT, tumor lumpectomy alone, mastectomy alone and mastectomy plus adjuvant RT. K\u0026ndash;M analysis revealed that patients receiving tumor lumpectomy plus adjuvant RT had better survival than patients receiving other treatments, indicating that lumpectomy plus adjuvant RT can improve survival and that BCS is a reasonable choice for breast ACC patients.\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eIn conclusion, our results show that the majority of ACCs were triple-negative, but our study also included a small number of hormone receptor-positive breast cancers. Compared with other types of breast cancer, ACC has no specificity for imaging, and FNAC may be a useful tool for diagnosis. The final diagnosis can only be assessed based on the results of histopathological and immunohistochemical examinations.\u003c/p\u003e"},{"header":"Declarations","content":"\u003cp\u003eAll co-authors have seen and agree with the contents of the manuscript and there is no financial interest to report.\u003c/p\u003e\n\u003cp\u003eConsent was given by the patient for publication and research purposes\u0026nbsp;\u003c/p\u003e"},{"header":"References","content":"\u003col\u003e\n \u003cli\u003eZhang, Meilin, et al. \u0026quot;Breast adenoid cystic carcinoma: a report of seven cases and literature review.\u0026quot; \u003cem\u003eBMC surgery\u003c/em\u003e 22.1 (2022): 113.\u0026rlm;\u003c/li\u003e\n \u003cli\u003eGlazebrook, Katrina N., et al. \u0026quot;Adenoid cystic carcinoma of the breast.\u0026quot; \u003cem\u003eAmerican Journal of Roentgenology\u003c/em\u003e 194.5 (2010): 1391-1396.\u0026rlm;\u003c/li\u003e\n \u003cli\u003eClaudia Gordillo, Anjeza Chukus,Adenoid cystic carcinoma: A case of rare breast cancer,Radiology Case Reports,Volume 17, Issue 3,2022,Pages 690-692,ISSN 1930-\u003c/li\u003e\n \u003cli\u003eGhabach, Bassam, et al. \u0026quot;Adenoid cystic carcinoma of the breast in the United States (1977 to 2006): a population-based cohort study.\u0026quot; \u003cem\u003eBreast Cancer Research\u003c/em\u003e 12 (2010): 1-9.\u0026rlm;\u003c/li\u003e\n \u003cli\u003eKhanfir, Kaouthar, et al. \u0026quot;Management of adenoid cystic carcinoma of the breast: a Rare Cancer Network study.\u0026quot; \u003cem\u003eInternational Journal of Radiation Oncology* Biology* Physics\u003c/em\u003e 82.5 (2012): 2118-2124.\u0026rlm;\u003c/li\u003e\n \u003cli\u003eRo, Jae Y., Elvio G. Silva, and H. Stephen Gallager. \u0026quot;Adenoid cystic carcinoma of the breast.\u0026quot; \u003cem\u003eHuman pathology\u003c/em\u003e 18.12 (1987): 1276-1281.\u0026rlm;\u003c/li\u003e\n \u003cli\u003eLakhani, Sunil R., et al. \u0026quot;WHO Classification of Tumors of the Breast.\u0026quot; (2012).\u0026rlm;\u003c/li\u003e\n \u003cli\u003eMiyai K, Schwartz MR, Divatia MK, Anton RC, Park YW, Ayala AG, Ro JY. Adenoid cystic carcinoma of breast: Recent advances. World J Clin Cases. 2014 Dec 16;2(12):732-41. doi: 10.12998/wjcc.v2.i12.732. PMID: 25516849; PMCID: PMC4266822.\u003c/li\u003e\n \u003cli\u003eGrabenstetter, A., Brogi, E., Zhang, H. \u003cem\u003eet al.\u003c/em\u003e Solid-basaloid variant of adenoid cystic carcinoma of the breast with near complete response to neoadjuvant chemotherapy. \u003cem\u003enpj Breast Cancer\u003c/em\u003e \u003cstrong\u003e8\u003c/strong\u003e, 93 (2022).\u0026nbsp;\u003ca href=\"https://doi.org/10.1038/s41523-022-00469-z\"\u003ehttps://doi.org/10.1038/s41523-022-00469-z\u003c/a\u003e\u003c/li\u003e\n \u003cli\u003eLi, L.; Zhang, D.; Ma, F. Adenoid Cystic Carcinoma of the Breast May Be Exempt from Adjuvant Chemotherapy. \u003cem\u003eJ. Clin. Med.\u003c/em\u003e \u003cstrong\u003e2022\u003c/strong\u003e, \u003cem\u003e11\u003c/em\u003e, 4477.\u0026nbsp;\u003ca href=\"https://doi.org/10.3390/jcm11154477\"\u003ehttps://doi.org/10.3390/jcm11154477\u003c/a\u003e\u003c/li\u003e\n \u003cli\u003eLeeming R,\u0026nbsp;Jenkins M,\u0026nbsp;Mendelsohn G. Adenoid Cystic Carcinoma of the Breast. \u003cem\u003eArch Surg.\u003c/em\u003e 1992;127(2):233\u0026ndash;235. doi:10.1001/archsurg.1992.01420020127019\u003c/li\u003e\n \u003cli\u003eBendari, Ahmed, et al. \u0026quot;Primary adenoid cystic carcinoma in the lung: Reporting two cases and mini-literature review.\u0026quot; \u003cem\u003eHuman Pathology Reports\u003c/em\u003e 35 (2024): 300727.\u003cspan dir=\"RTL\"\u003e\u0026rlm;\u003c/span\u003e\u003c/li\u003e\n \u003cli\u003eKleer, Celina G. M.D.; Oberman, Harold A. M.D..\u0026nbsp;Adenoid Cystic Carcinoma of the Breast: Value of Histologic Grading and Proliferative Activity. The American Journal of Surgical Pathology 22(5):p 569-575, May 1998.\u003c/li\u003e\n \u003cli\u003eBendari, Ahmed, et al. \u0026quot;Papillary Thyroid Carcinoma With Lymphoepithelial Features and Lacking Association With Epstein-Barr Virus (EBV): A Rare Case.\u0026quot; \u003cem\u003eCureus\u003c/em\u003e 16.2 (2024).\u003cspan dir=\"RTL\"\u003e\u0026rlm;\u003c/span\u003e\u003c/li\u003e\n\u003c/ol\u003e"}],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":true,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":true,"hideJournal":true,"highlight":"","institution":"Fundación Valle del Lili","isAcceptedByJournal":false,"isAuthorSuppliedPdf":false,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":true,"isPdf":false,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"adenoid cystic carcinoma, CD117","lastPublishedDoi":"10.21203/rs.3.rs-4104201/v4","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-4104201/v4","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003eAdenoid cystic carcinoma is a rare form of breast cancer accounting for 0.1%-1.0% of all mammary cancer malignancies. Breast cancer is characterized by an indolent clinical course and favorable prognosis, contrary to other breast cancers. Diagnostic mammogram and breast ultrasound play a pivotal role in the early detection and diagnosis of breast adenoid cystic carcinoma. Treatment may consist of lumpectomy and radiation therapy vs mastectomy alone. Although rare, late disease recurrence and metastasis have been reported in the literature; thus, long-term surveillance is of utmost importance for these patients. We will review the literature and discuss the case of a 52-year-old female who presented with a palpable lump of the right breast, which was pathologically proven to be adenoid cystic carcinoma of the breast.\u003c/p\u003e","manuscriptTitle":"Adenoid Cystic Carcinoma of the Breast: A Case Report","msid":"","msnumber":"","nonDraftVersions":[{"code":4,"date":"2024-07-18 17:26:32","doi":"10.21203/rs.3.rs-4104201/v4","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}},{"code":3,"date":"2024-04-16 22:01:40","doi":"10.21203/rs.3.rs-4104201/v3","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}},{"code":2,"date":"2024-03-25 19:33:45","doi":"10.21203/rs.3.rs-4104201/v2","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}},{"code":1,"date":"2024-03-18 17:16:07","doi":"10.21203/rs.3.rs-4104201/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"4aae9ce8-0c87-4f9a-8f75-a83469c07cc4","owner":[],"postedDate":"July 18th, 2024","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[{"id":30770332,"name":"Pathology"}],"tags":[],"updatedAt":"2024-03-18T17:16:07+00:00","versionOfRecord":[],"versionCreatedAt":"2024-07-18 17:26:32","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v4","identity":"rs-4104201","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-4104201","identity":"rs-4104201","version":["v4"]},"buildId":"qtupq5eGEP_6zYnWcrvyt","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}