Natural Mucus as Biomaterial Dressings: A Novel Approach to Accelerate Wound Healing

Natural Mucus as Biomaterial Dressings: A Novel Approach to Accelerate Wound Healing | Authorea try { document.documentElement.classList.add('js'); } catch (e) { } var _gaq = _gaq || []; _gaq.push(['_setAccount', 'G-8VDV14Y67G']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 'https://ssl' : 'http://www') + '.google-analytics.com/ga.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s); })(); Skip to main content Preprints Collections Wiley Open Research IET Open Research Ecological Society of Japan All Collections About About Authorea FAQs Contact Us Quick Search anywhere Search for preprint articles, keywords, etc. Search Search ADVANCED SEARCH SCROLL This is a preprint and has not been peer reviewed. Data may be preliminary. 23 March 2025 V1 Latest version Share on Natural Mucus as Biomaterial Dressings: A Novel Approach to Accelerate Wound Healing Authors : Xuanqi Peng , Ziyi Wang , Leo Wang , and Weiliang Hou 0000-0001-6330-3760 [email protected] Authors Info & Affiliations https://doi.org/10.22541/au.174274759.93401669/v1 212 views 104 downloads Contents Abstract Supplementary Material Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Effective wound healing remains a critical focus of intensive research. Traditional wound dressings with limited functionality and passive protection fail to meet the multifaceted demands of clinical wound management, while modern synthetic dressings still lack the capacity to emulate sophisticated biological healing mechanisms. Natural mucus from amphibians, mollusks, plants, and microbes exhibits unique dynamic bioadhesion and multi-component synergy. These properties enable effective intervention in complex wound models, including organ hemostasis, diabetic ulcers, and severe burns. Characterized by unique viscoelastic properties and dynamic interfacial adaptability, these biopolymeric matrices demonstrate superior biocompatibility coupled with multifaceted therapeutic actions, including mucopolysaccharide-mediated hydration maintenance, pathogen sequestration through glycoprotein interactions, and growth factor modulation for enhanced tissue regeneration. In this review, we explore the key functions of natural mucus in various wound healing models. By elucidating the molecular mechanisms underlying their therapeutic efficacy and comparing performance metrics with clinical wound dressings, we establish a scientific rationale for mucus-inspired biomaterial design. This comprehensive assessment not only reveals the untapped potential of renewable biological resources in developing eco-friendly, high-performance wound care alternatives but also provides theoretical guidance for developing next-generation smart dressings with bioactive, self-adaptive, and environmentally responsive characteristics. Supplementary Material File (for exploration.docx) Download 11.05 MB Information & Authors Information Version history V1 Version 1 23 March 2025 Copyright This work is licensed under a Non Exclusive No Reuse License. Keywords hydrogel natural mucus wound healing Authors Affiliations Xuanqi Peng University of Macau Institute of Chinese Medical Science View all articles by this author Ziyi Wang University of Macau Institute of Chinese Medical Science View all articles by this author Leo Wang Kitsilano Secondary School View all articles by this author Weiliang Hou 0000-0001-6330-3760 [email protected] Changhai Hospital View all articles by this author Metrics & Citations Metrics Article Usage 212 views 104 downloads .FvxKWukQNSOunydq8rnd { width: 100px; } Citations Download citation Xuanqi Peng, Ziyi Wang, Leo Wang, et al. Natural Mucus as Biomaterial Dressings: A Novel Approach to Accelerate Wound Healing. Authorea . 23 March 2025. DOI: https://doi.org/10.22541/au.174274759.93401669/v1 If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download. 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