Prognostic factors for IVF-ICSI live birth rate in women with endometriosis-related infertility

INTRODUCTION: The present study aims to identify the factors contributing to diminished successful cumulative live birth rate (LBR) of in-vitro fertilisation-intra-cytoplasmic sperm injection (IVF-ICSI) among patients with endometriosis. MATERIALS AND METHODS: In this study, a retrospective cohort investigation was conducted from January 2016 to December 2022 at the Reproductive Medicine Center, Department of Obstetrics and Gynaecology, Sultanah Bahiyah Hospital, Alor Setar, Malaysia. Various determinants influencing substandard cumulative IVF-ICSI LBR prognosis in women diagnosed with endometriosis were analysed. A total of 157 patients, representing 214 IVF-ICSI cycles and 231 embryo transfers, were involved in the current study. The cumulative LBR per cycle was the primary outcome established. RESULTS: The present study recorded 25.7% (n=55) cumulative LBR per cycle. Prolonged infertility (95% confidence intervals, 95%CI: 0.33, 0.86, p=0.009), moderate to severe endometriosis (95%CI: 0.001, 0.39, p=0.009), and adenomyosis (95%CI: 0.013, 0.98, p=0.048) were factors that significantly reduced the cumulative LBR. CONCLUSION: A prolonged infertility duration, the presence of adenomyosis, and moderate to severe endometriosis negatively impacted the cumulative LBR in IVF-ICSI treatments for women with endometriosis. Consequently, early aggressive infertility treatments for patients diagnosed with endometriosis are recommended.