The Clinical Significance of Preoperative Plasma Fibrinogen Levels and Platelet Count in Resectable Colon Cancer

Background: and aims: There is still much unknown about the relationship between colon cancer and markers of hemostasis. İn these study, whether or not preoperative platelet (PLT) counts, plasma fibrinogen levels were associated with postoperative lymph node involvement and venous invasion was evaluated in patients of colon cancer. Methods: Eighty patients (mean age: 58.09 years, 37% females, 63% male) were retrospectively included in this study. Results: PLT and fibrinogen values in patients with lymph node and venous invasion negative colon cancer; were significantly lower than patients with positive lymph node (p<0.001, all of them) and venous invasion (p<0.001, all of them). A positive correlation was found between the venous invasion and lymphatic involvement with PLT count and plasma fibrinogen levels (r=0.640, p<0.001; r=0.810, p<0.001, respectively). Conclusion: It was concluded that preoperative PLT count and plasma fibrinogen levels may be useful marker for monitoring postoperative lymph node involvement and venous invasion in patients with colon cancer.