Prohibitin2/PHB2, Transcriptionally Regulated by GABPA, Inhibits Cell Growth via PRKN/Parkin-dependent Mitophagy in Endometriosis

Yupeng Deng, Tong Lou, Lili Kong, Chongdong Liu
Reproductive sciences (Thousand Oaks, Calif.) · 2023 · vol. 30(12) , pp. 3629–3640 · doi:10.1007/s43032-023-01316-7 · PMID:37587393 · W4385872361
article OA: closed CC0 ⤵ 4 in-corpus citations
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-07 ⓘ

Prohibitin 2 (PHB2) is downregulated in endometriosis, where it inhibits cell growth via Parkin-mediated mitophagy, and its transcription is regulated by GABPA.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 ⓘ

The study investigated how prohibitin 2 (PHB2), transcriptionally regulated by GABPA, affects endometriosis by modulating PRKN/Parkin-dependent mitophagy and related cell behaviors. Using ectopic and normal ovarian endometrial tissues from patients with endometriosis, along with endometrial cell lines with PHB2 overexpression or knockdown, the authors measured PHB2 mRNA/protein levels and assessed proliferation, migration, invasion, apoptosis, and mitochondrial/autophagy/mitophagy marker changes. PHB2 was downregulated in ectopic endometrium, and restoring PHB2 inhibited proliferation, migration, and invasion while promoting apoptosis, alongside increased mitophagy markers (Parkin, LC3II/I) and decreased autophagy-related markers (P62, TOMM20), with GABPA identified as directly binding the PHB2 promoter to control its transcription. The paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Mitophagy Mitophagy Mitophagy Mitophagy Mitophagy Mitophagy Mitophagy Autophagy Autophagy Autophagy Autophagy Autophagy

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