The Efficacy of L-glutamine in Osteoarthritis:a comparative analysis with celecoxib and glucosamine sulfate.

The Efficacy of L-glutamine in Osteoarthritis:a comparative analysis with celecoxib and glucosamine sulfate. | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article The Efficacy of L-glutamine in Osteoarthritis:a comparative analysis with celecoxib and glucosamine sulfate. Wendan Cheng, Zhongyao Hu, Changming Wang, chen wang, Junyan He, and 10 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-3986159/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Objective: to explore the therapeutic efficacy of L-glutamine (L-Gln) in osteoarthritis(OA), and compare with glucosamine sulfate (GS), and celecoxib (CXB). Methods: Male SD rats were administered sodium chloride, L-Gln, GS, or CXB via gavage for eight weeks starting in the fifth week after operation. Then the severity of knee OA in rats was evaluated by serological analysis, histological examination and imaging examination. Patients with mild OA were administered L-Gln, GS, or CXB orally for 12 weeks in accordance with the randomization principle. Efficacy end points were the change from baseline to week 24 in the pain and physical function subscale scores of the Western Ontario and McMaster Universities OA Index (WOMAC), and Lequesne score. Results: The treatment with L-Gln and two other drugs alleviated the increased concentration of serum cartilage degradation markers, cartilage destruction, osteophyte formation, and loss of subchondral bone mass caused by OA in rats. During follow-up, the WOMAC pain and physical function subscale scores and Lequesne score of all three groups of patients decreased from baseline and exceeded the minimum clinical difference. The results indicate that the therapeutic effect of L-Gln is comparable to the other two drugs, and in some indicators, it may even be superior to them. Conclusion: Our research indicates that L-Gln is comparable to GS and CXB in improving the pathological progression and clinical efficacy of OA. However, L-Gln has a lower occurrence of gastrointestinal adverse reactions and effectively alleviates knee joint pain in OA patients who are unresponsive to NSAIDs and GS. This makes it a promising drug for the treatment of osteoarthritis. Osteoarthritis L-glutamine Full Text Supplementary Files SupplementaryTable1.xlsx Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-3986159","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":276806662,"identity":"32fe9692-f915-4a11-ab06-94add830960a","order_by":0,"name":"Wendan 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L-glutamine","lastPublishedDoi":"10.21203/rs.3.rs-3986159/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-3986159/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003eObjective: to explore the therapeutic efficacy of L-glutamine (L-Gln) in osteoarthritis(OA), and compare with glucosamine sulfate (GS), and celecoxib (CXB).\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eMethods: Male SD rats were administered sodium chloride, L-Gln, GS, or CXB via gavage for eight weeks starting in the fifth week after operation. Then the severity of knee OA in rats was evaluated by serological analysis, histological examination and imaging examination. Patients with mild OA were administered L-Gln, GS, or CXB orally for 12 weeks in accordance with the randomization principle. Efficacy end points were the change from baseline to week 24 in the pain and physical function subscale scores of the Western Ontario and McMaster Universities OA Index (WOMAC), and Lequesne score.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eResults: The treatment with L-Gln and two other drugs alleviated the increased concentration of serum cartilage degradation markers, cartilage destruction, osteophyte formation, and loss of subchondral bone mass caused by OA in rats. During follow-up, the WOMAC pain and physical function subscale scores and Lequesne score of all three groups of patients decreased from baseline and exceeded the minimum clinical difference. The results indicate that the therapeutic effect of L-Gln is comparable to the other two drugs, and in some indicators, it may even be superior to them.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eConclusion: Our research indicates that L-Gln is comparable to GS and CXB in improving the pathological progression and clinical efficacy of OA. However, L-Gln has a lower occurrence of gastrointestinal adverse reactions and effectively alleviates knee joint pain in OA patients who are unresponsive to NSAIDs and GS. This makes it a promising drug for the treatment of osteoarthritis.\u003c/p\u003e","manuscriptTitle":"The Efficacy of L-glutamine in Osteoarthritis:a comparative analysis with celecoxib and glucosamine sulfate.","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2024-03-11 05:26:28","doi":"10.21203/rs.3.rs-3986159/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"b28813fe-7d43-441f-8cb5-322539874ac3","owner":[],"postedDate":"March 11th, 2024","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[],"tags":[],"updatedAt":"2024-11-26T12:08:29+00:00","versionOfRecord":[],"versionCreatedAt":"2024-03-11 05:26:28","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-3986159","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-3986159","identity":"rs-3986159","version":["v1"]},"buildId":"qtupq5eGEP_6zYnWcrvyt","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}