Effect of laparoscopic surgery on hemostatic function in patients with ovarian endometriosis

Objective To explore the effect of laparotomy surgery (AH) and laparoscopic surgery (LH) on hemostatic function in patients with ovarian endometriosis.Methods 60 ASA Ⅰ-Ⅱ patients with endometriosis were selected and then randomly divided into two groups,30 for each group.The two groups received AH or LH.Prothrombin time (PT),activated partial thromboplastin time (APTT),thrombin time (TT),platelet count,D-dimer,fibrinogen,and von Willebrand factor content were detected before anesthesia,at 15,30,and 60 minutes during anesthesia,completion of procedure,and 24,48,and 72 h after anesthesia.Results As compared with the baselines,PT,APTT,and TT were prolonged in group AH and group LH at 15,30,and 60 minutes during anesthesia,and completion of procedure (P＜0.05),and they were longer in group AH than in group LH (P＜0.05).The contents of PLT and FBG were declined in both groups at completion of anesthesia and 24,48,and 72 after anesthesia as compared with the baselines (P＜0.05),and they were lower in group AH than in group LH at the same time points after anesthesia (P＜0.05).The contents of DD and vWF were significantly higher in both group AH and group LH as compared with the baselines (P＜0.01),and they were significantly higher in group AH than in group LH at the same time points after anesthesia (P＜0.05).Conclusions Laparoscopic surgery has less effect on hemostatic function than laparotomy surgery in patients with ovarian endometriosis. Key words: Laparoscopic surgery;  Ovarian endometriosis;  Hemostatic function