STUSC: selection tests under size change

Summary Natural selection leaves signatures in genetic diversity. A challenge in detecting these signatures is that demographic history can shape genetic variation in ways similar to selection, making their effects difficult to disentangle. STUSC takes a simulation based approach to the problem. It performs five widely used tests for natural selection, Tajima’s D, Fu and Li’s F and F*, and Fu and Li’s D and D*, which ordinarily require the assumption of constant population size, under any size history. It also provides methods for generating their statistical distributions, allowing their responses to demography to be studied and past results to be evaluated. Availability and implementation STUSC is written in Java, and is freely available at the author’s website, woodinglab.org/stusc Contact [email protected]