Therapeutic Effect of Levonorgestrel-releasing Intrauterine System Combined with Guizhi Fulin Capsules Treating Adenomyosis

Objective To evaluate the therapeutic effect of levonorgestrel-releasing intrauterine system(LNG-IUS) combined with Guizhi Fulin capsules treating adenomyosis.Methods A total of 108 patients with adenomyosis diagnosed in our hospital from February 2006 to February 2010 were randomly divided into the observation group(n=56) and the control group(n=52).The patients in the observation group were treated with LNG-IUS and simultaneously administrated orally with the Guizhi Fulin capsules(three capsules per time,three times per day for six continuous months).The patients in the control group were treated with LNG-IUS only.The changes of the menstrual blood volume,severity of dysmenorrhea,uterine volume and the level of serum CA125 were observed and evaluated.Results After six months' treatment,dysmenorrhea of all the patients was obviously alleviated,the menstrual blood volume reduced significantly,the uterine volume shrank,and the level of serum CA125 decreased significantly;the results after the treatment differed much from that before the treatment(P0.05).Compared with those in the control group,the differences in the grades of the dysmenorrheal,shrinkage of the uterine volume and the level of serum CA125 were statistically significant(P0.05).Conclusions Combined usage of LNG-IUS and Guizhi Fulin capsules is an effective and safe way treating adenomyosis.