Editorial: Immunology at the feto-maternal interface

Amir-Hassan Zarnani, Zarnani AH, Jeddi-Tehrani M, Mahmood Jeddi-Tehrani, Marie-Pierre Piccinni, Piccinni MP, Maria Laura Zenclussen, Zenclussen ML
Frontiers in immunology · 2025 · vol. 16 , pp. 1667375 · doi:10.3389/fimmu.2025.1667375 · PMID:40873586 · PMC12378058
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This editorial discusses immunology at the feto-maternal interface.

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This editorial piece explores the immunological mechanisms occurring at the feto-maternal interface, focusing on how maternal immune tolerance is established and maintained during pregnancy. The authors discuss the complex interactions between fetal antigens and maternal immune cells that prevent rejection while allowing for successful gestation. No original experimental data or clinical trial results are presented, as the work serves as a conceptual overview of current immunological understanding in this context. The paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

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A-HZ: Conceptualization, Writing – review & editing, Writing – original draft. MJ-T: Writing – review & editing. M-PP: Writing – review & editing. MZ: Writing – review & editing.

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The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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