The effect of placental transfusion on hemodynamics in premature newborns: a randomized controlled trial

Introduction: Despite of growing evidence of the beneficial effects of placental transfusions techniques, no available sufficient data about their effects on vulnerable hemodynamics and myocardium of premature infants. purpose Study ventricular functions and hemodynamics after different techniques of placental transfusions techniques, Delayed cord clamping (DCC), Cut cord milking (C-UCM), and intact cord milking (I-UCM). methods: Infants delivered whether by Cs-section or vaginal delivery were randomly assigned to undergo C- UCM (20-30cm), I- UCM (3-4 strippings), and DCC (30–60 seconds). Functional echocardiography was done at 24 hour and 72-96 hours of life. This trial was registered in the clinical trial gov NCT04811872. Results: Of a total 196 preterm infants ≤32 weeks were enrolled in the study 57 infants were eligible and randomly assigned to the three groups. neonates randomly assigned to DCC had significantly higher superior vena cava flow and lower right ventricular systolic function in the first 24 hours of life. This finding vanished at day 3. Neonates undergone different methods of placental transfusions had similar hemoglobin, admission temperature, and mean blood pressure in the first 24 hours of life. Conclusion: Placental transfusion techniques may benefit premature neonates ≤32 weeks, but they have been shown to alter their hemodynamics and myocardial function.