Studies on the histogenesis of cervical adenocarcinoma

Noda K, K. Noda, K Kimura, Kimura K, Ikeda M, M Ikeda, Teshima K, K Teshima
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists · 1983 · doi:10.1097/00004347-198301040-00003 · PMID:6885223
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This study analyzed cervical adenocarcinoma histogenesis, finding that endocervical adenocarcinoma originates from primary clefts while endometrioid adenocarcinoma arises from deepest tunnels and ectopic endometrial glands.

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This study examined the histogenesis of cervical adenocarcinoma by analyzing uterine cervixes from 58 patients with various stages of the disease and 210 healthy controls. The researchers identified that endocervical adenocarcinoma likely originates from the primary cleft, whereas endometrioid adenocarcinoma arises mainly from cells in the deepest tunnels or ectopic endometrial glands. A key finding was the observation of ectopic endometrial glands in two control cases, supporting the theory that endometrioid variants may develop from such tissue. Relevance to endometriosis: The paper discusses ectopic endometrial glands as a potential origin for endometrioid adenocarcinoma, linking it tangentially to endometriosis research through the presence of misplaced endometrial-like tissue.

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Abstract

The uterine cervices of 58 patients with cervical adenocarcinoma (seven in situ, 16 microinvasive, and 35 frank invasive) were studied along with 210 cervices that did not show any disease. Squamous metaplasia was confirmed in surface and cleft epithelium, but not in the deepest area of the gland-bearing portion of the cervix. Ectopic endometrial glands were observed in two of the 210 cases. The maximum extent of in situ and microinvasive endocervical adenocarcinoma was located in the area of the primary cleft; and that of endometrioid adenocarcinoma, in the deepest area of the gland-bearing portion. It is suggested that endocervical adenocarcinoma originates from the primary cleft and that neoplastic epithelium replaces normal gland epithelium starting from the shallow part of the cleft and spreading to the deep part of the cervical canal. Endometrioid adenocarcinoma is considered to originate mainly from the cells of the deepest tunnels, as well as from ectopic endometrial glands; its initial growth occurring by means of invasive proliferation into the stroma.
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Studies on the Histogenesis of Cervical Adenocarcinoma - Kiichiro Noda - Kenzo Kimura - Masanori Ikeda - Kensaku Teshima Summary: The uterine cervixes of 58 patients with cervical adenocarcinoma (seven in situ, 16 microinvasive, and 35 frank invasive) were studied along with 210 cervixes that did not show any disease. Squamous metaplasia was confirmed in surface and cleft epithelium, but not in the deepest area of the gland-bearing portion of the cervix. Ectopic endometrial glands were observed in two of the 210 cases. The maximum extent of in situ and microinvasive endocervical adenocarcinoma was located in the area of the primary cleft; and that of endometrioid adenocarcinoma, in the deepest area of the gland-bearing portion. It is suggested that endocervical adenocarcinoma originates from the primary cleft and that neoplastic epithelium replaces normal gland epithelium starting from the shallow part of the cleft and spreading to the deep part of the cervical canal. Endometrioid adenocarcinoma is considered to originate mainly from the cells of the deepest tunnels, as well as from ectopic endometrial glands; its initial growth occurring by means of invasive proliferation into the stroma.

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Condition tags

endometriosis

MeSH descriptors

Adenocarcinoma Uterine Cervical Neoplasms Adenocarcinoma Adenocarcinoma Carcinoma in Situ Carcinoma in Situ Cervix Uteri Cervix Uteri Endometriosis Endometriosis Female Humans Uterine Cervical Neoplasms Uterine Cervical Neoplasms

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europepmc
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pubmed
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