Clinical analysis on Danazol Suppository on treatment of recurrent endometriosis

Objective To observe the efficacy and adverse reactions of Danazol Suppository(DS) in the treatment of recurrent endometriosis.Methods Eighty-seven patients with recurrent endometriosis diagnosed by open and laparoscopic operation were randomly single-blind divided into two groups.DS group with 46 cases was administrated with two pills in the first month every evening and then one pill every evening via vaginal or anal administration,and the course was six months.The control group with 41 cases was po administrated with Danazol Capsule(DC) twice daily,for six months and regular follow-up.The symptoms,physical signs,and adverse reactions of DS and DC in the treatment of recurrent endometriosis were observed and compared.Results There were no significant differences in the improvement rates of dysmenorrhea,lower abdominal pain in non menstrual,the pain during pareunia and after excavation nodules,and rectal pain between DS and DC groups(P 0.05).But in DS group,the incidence of body weight change,elevated transaminases,abnormal vaginal bleeding,amenorrhea,and acne adverse reaction was significantly lower than that in DC group(P0.05).Conclusion The effect of DS in the treatment of recurrent endometriosis is similar to that of DC,but adverse reactions are significantly decreased compared with DC,in high security.