Progestin Receptors in the Anterior Pituitary and Hypothalamus of Male Rats

Oddvar Næss, Arne Attramadal
In: International Journal of Andrology · 1978 · vol. 1(s2a) , pp. 175–183 · doi:10.1111/j.1365-2605.1978.tb00016.x · W2075645469
article OA: bronze CC0
🔓 Open OA copy View on OpenAlex View at publisher

Abstract

Properties of progestin receptors in the pituitary and hypothalamic cytosol fraction of male rats were studied using the highly potent progestin ( 3 H) R 5020 (17,20‐dimethyl‐19‐nor‐pregna‐4,9‐diene‐3,20‐dione). As shown by sucrose gradient analysis, specific binding of ( 3 H) R 5020 is associated with components migrating at 7 S and 4 S. The isoelectric point of the binding components were 5.8. The binding of ( 3 H) R 5020 is highly specific since it is easily displaced by unlabelled R 5020 and progesterone. The affinity of unlabelled testosterone, 17β‐estradiol and cyproterone acetate was much lower, whereas unlabelled cortisol had no affinity for the progestin receptor. The dissociation constant of pituitary R 5020 binding is approximately 1 times 10 ‐9 M. Pretreatment of the animals with 17β‐estradiol‐valerate greatly increased the progestin receptor levels in the tissues.

My notes (saved in your browser only)

Citation neighborhood (no data yet)

We don't have any in-corpus citations linked to this paper yet. The paper's references may be in our DB but unresolved to ``paper_id`` (resolution happens at ingest when the cited DOI matches a row we already have). Run the cross-source citation reconcile pass to retry.

References (23)

Source provenance

openalex
last seen: 2026-05-10T11:45:21.513534+00:00
License: CC0 · commercial use OK