子宮内膜症においてエピジェネティクスにより発現が抑制されているmiR-503は,子宮内膜症間質細胞に対してアポトーシス促進、細胞周期停止,細胞増殖抑制,血管新生抑制,収縮能抑制に働く

Study question: Is the micro-RNA (miRNA) miR-503, downregulated in endometriotic cyst stromal cells (ECSCs) and does this affect the cell cycle, cell proliferation, angiogenesis and contractility of these cells? SUMMARY ANSWER: miR-503 expression is downregulated in ECSCs by DNA hypermethylation and this contributes to their proliferation, resistance to apoptosis, extracellular matrix (ECM) contractility and angiogenesis through effects on cyclin D1, B-cell lymphoma/leukemia (Bcl)-2, Ras homology A and vascular endothelial growth factor A (VEGF-A).