Quantitative MRI Evaluation of the Effects of Rest and Different Intensities of Running on the Recovery of Thigh Muscle Microdamage After a Half Marathon

Quantitative MRI Evaluation of the Effects of Rest and Different Intensities of Running on the Recovery of Thigh Muscle Microdamage After a Half Marathon | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Quantitative MRI Evaluation of the Effects of Rest and Different Intensities of Running on the Recovery of Thigh Muscle Microdamage After a Half Marathon Jing Zhou¹, Chengyuan Xu¹, Yawen Wu², Xinmiao Mao¹, Zhenqi Hu¹, and 3 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-7720608/v1 This work is licensed under a CC BY 4.0 License Status: Published Journal Publication published 07 Mar, 2026 Read the published version in BMC Sports Science, Medicine and Rehabilitation → Version 1 posted 13 You are reading this latest preprint version Abstract Objective To explore the application value of quantitative magnetic resonance multi-parameter imaging technology, namely Diffusion Tensor Imaging (DTI) combined with T2 mapping, in evaluating the effects of rest and different intensities of running on the recovery of thigh muscle microdamage after a Half Marathon (HM). Methods Twenty-four amateur marathon runners were enrolled and divided into three groups: the High-Intensity Running (HIR) group, the Moderate-Intensity Running (MIR) group, and the Rest (REST) group. MR scans were performed on the participants before the race (pre-run) and at 3 hours (post-3h), 24 hours (post-24h), 48 hours (post-48h), and 72 hours (post-72h) after the race. The Fractional Anisotropy (FA), Apparent Diffusion Coefficient (ADC), and T2 relaxation time (T2 value) of the thigh muscle groups were measured. Results At post-3h, the FA values in all three groups decreased significantly (P<0.001) and the T2 values increased significantly (P<0.001), indicating that HM induced muscle microdamage. In the REST group, the FA values began to recover at post-24h and returned to the pre-run level at post-72h. In the MIR group, the FA values started to recover at post-48h but did not fully recover by post-72h. In the HIR group, there was no significant recovery of FA values throughout the observation period (P>0.99). The change trend of T2 values was consistent with that of FA values. Conclusion Quantitative MR multi-parameter imaging can sensitively detect muscle microdamage and the recovery process after HM. The REST group showed the fastest recovery, while moderate- and high-intensity running delayed recovery. Therefore, it is not recommended to use running as an intervention within 3 days after the race. Half Marathon Muscle Microdamage Diffusion Tensor Imaging (DTI) T2 mapping Recovery Strategy Full Text Additional Declarations No competing interests reported. Cite Share Download PDF Status: Published Journal Publication published 07 Mar, 2026 Read the published version in BMC Sports Science, Medicine and Rehabilitation → Version 1 posted Editorial decision: Revision requested 16 Dec, 2025 Reviews received at journal 12 Dec, 2025 Reviews received at journal 21 Oct, 2025 Reviews received at journal 20 Oct, 2025 Reviewers agreed at journal 19 Oct, 2025 Reviewers agreed at journal 16 Oct, 2025 Reviewers agreed at journal 15 Oct, 2025 Reviewers agreed at journal 13 Oct, 2025 Reviewers invited by journal 09 Oct, 2025 Editor invited by journal 07 Oct, 2025 Editor assigned by journal 05 Oct, 2025 Submission checks completed at journal 05 Oct, 2025 First submitted to journal 26 Sep, 2025 You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-7720608","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":532805160,"identity":"dc3106fc-cbd7-4a8e-b51b-33cdfaf80db8","order_by":0,"name":"Jing Zhou¹","email":"","orcid":"","institution":"The Affiliated Hospital of Hangzhou Normal University","correspondingAuthor":false,"prefix":"","firstName":"Jing","middleName":"","lastName":"Zhou¹","suffix":""},{"id":532805161,"identity":"49b79ddb-c566-4d26-bfa1-1902ae2dd64a","order_by":1,"name":"Chengyuan Xu¹","email":"","orcid":"","institution":"The Affiliated Hospital of Hangzhou Normal 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Marathon","fulltext":[],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":false,"highlight":"","institution":"","isAcceptedByJournal":true,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":true,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"bmc-sports-science-medicine-and-rehabilitation","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"ssmr","sideBox":"Learn more about [BMC Sports Science, Medicine and Rehabilitation](http://bmcsportsscimedrehabil.biomedcentral.com/)","snPcode":"","submissionUrl":"https://www.editorialmanager.com/ssmr/default.aspx","title":"BMC Sports Science, Medicine and Rehabilitation","twitterHandle":"BMC_series","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"em","reportingPortfolio":"BMC Series","inReviewEnabled":true,"inReviewRevisionsEnabled":true},"keywords":"Half Marathon, Muscle Microdamage, Diffusion Tensor Imaging (DTI), T2 mapping, Recovery Strategy","lastPublishedDoi":"10.21203/rs.3.rs-7720608/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-7720608/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"Objective To explore the application value of quantitative magnetic resonance multi-parameter imaging technology, namely Diffusion Tensor Imaging (DTI) combined with T2 mapping, in evaluating the effects of rest and different intensities of running on the recovery of thigh muscle microdamage after a Half Marathon (HM). Methods Twenty-four amateur marathon runners were enrolled and divided into three groups: the High-Intensity Running (HIR) group, the Moderate-Intensity Running (MIR) group, and the Rest (REST) group. MR scans were performed on the participants before the race (pre-run) and at 3 hours (post-3h), 24 hours (post-24h), 48 hours (post-48h), and 72 hours (post-72h) after the race. The Fractional Anisotropy (FA), Apparent Diffusion Coefficient (ADC), and T2 relaxation time (T2 value) of the thigh muscle groups were measured. Results At post-3h, the FA values in all three groups decreased significantly (P\u003c0.001) and the T2 values increased significantly (P\u003c0.001), indicating that HM induced muscle microdamage. In the REST group, the FA values began to recover at post-24h and returned to the pre-run level at post-72h. In the MIR group, the FA values started to recover at post-48h but did not fully recover by post-72h. In the HIR group, there was no significant recovery of FA values throughout the observation period (P\u003e0.99). The change trend of T2 values was consistent with that of FA values. Conclusion Quantitative MR multi-parameter imaging can sensitively detect muscle microdamage and the recovery process after HM. The REST group showed the fastest recovery, while moderate- and high-intensity running delayed recovery. Therefore, it is not recommended to use running as an intervention within 3 days after the race.","manuscriptTitle":"Quantitative MRI Evaluation of the Effects of Rest and Different Intensities of Running on the Recovery of Thigh Muscle Microdamage After a Half Marathon","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2025-10-22 14:32:42","doi":"10.21203/rs.3.rs-7720608/v1","editorialEvents":[{"type":"communityComments","content":0},{"type":"decision","content":"Revision requested","date":"2025-12-16T13:52:54+00:00","index":"","fulltext":""},{"type":"editorInvitedReview","content":"","date":"2025-12-12T21:18:38+00:00","index":"hide","fulltext":""},{"type":"editorInvitedReview","content":"","date":"2025-10-21T07:48:16+00:00","index":"hide","fulltext":""},{"type":"editorInvitedReview","content":"","date":"2025-10-20T19:36:07+00:00","index":"hide","fulltext":""},{"type":"reviewerAgreed","content":"165922658807847045662048167812006121119","date":"2025-10-20T03:04:52+00:00","index":"hide","fulltext":""},{"type":"reviewerAgreed","content":"104605810951186601417760484816412494648","date":"2025-10-16T19:14:51+00:00","index":"hide","fulltext":""},{"type":"reviewerAgreed","content":"1989150695211451483053874754336528524","date":"2025-10-15T16:06:54+00:00","index":"hide","fulltext":""},{"type":"reviewerAgreed","content":"79168281943749544662793497344329017014","date":"2025-10-13T12:36:23+00:00","index":"hide","fulltext":""},{"type":"reviewersInvited","content":"","date":"2025-10-09T06:59:27+00:00","index":"","fulltext":""},{"type":"editorInvited","content":"","date":"2025-10-07T04:18:33+00:00","index":"","fulltext":""},{"type":"editorAssigned","content":"","date":"2025-10-06T03:41:48+00:00","index":"","fulltext":""},{"type":"checksComplete","content":"","date":"2025-10-06T03:40:44+00:00","index":"","fulltext":""},{"type":"submitted","content":"BMC Sports Science, Medicine and Rehabilitation","date":"2025-09-26T10:06:23+00:00","index":"","fulltext":""}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"bmc-sports-science-medicine-and-rehabilitation","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"ssmr","sideBox":"Learn more about [BMC Sports Science, Medicine and Rehabilitation](http://bmcsportsscimedrehabil.biomedcentral.com/)","snPcode":"","submissionUrl":"https://www.editorialmanager.com/ssmr/default.aspx","title":"BMC Sports Science, Medicine and Rehabilitation","twitterHandle":"BMC_series","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"em","reportingPortfolio":"BMC Series","inReviewEnabled":true,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"75391fb2-8ada-4d1b-ab0d-df079977b0e9","owner":[],"postedDate":"October 22nd, 2025","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"published-in-journal","subjectAreas":[],"tags":[],"updatedAt":"2026-03-09T16:10:10+00:00","versionOfRecord":{"articleIdentity":"rs-7720608","link":"https://doi.org/10.1186/s13102-026-01640-w","journal":{"identity":"bmc-sports-science-medicine-and-rehabilitation","isVorOnly":false,"title":"BMC Sports Science, Medicine and Rehabilitation"},"publishedOn":"2026-03-07 15:59:21","publishedOnDateReadable":"March 7th, 2026"},"versionCreatedAt":"2025-10-22 14:32:42","video":"","vorDoi":"10.1186/s13102-026-01640-w","vorDoiUrl":"https://doi.org/10.1186/s13102-026-01640-w","workflowStages":[]},"version":"v1","identity":"rs-7720608","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-7720608","identity":"rs-7720608","version":["v1"]},"buildId":"8U1c8b4HqxoKbykW_rLl7","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}