In Vitro Anti-sickling and Polymerization Inhibition Potentials of Trigonella foenum-graecum and Syzygium aromaticum

In Vitro Anti-sickling and Polymerization Inhibition Potentials of Trigonella foenum-graecum and Syzygium aromaticum | Authorea try { document.documentElement.classList.add('js'); } catch (e) { } var _gaq = _gaq || []; _gaq.push(['_setAccount', 'G-8VDV14Y67G']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 'https://ssl' : 'http://www') + '.google-analytics.com/ga.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s); })(); Skip to main content Preprints Collections Wiley Open Research IET Open Research Ecological Society of Japan All Collections About About Authorea FAQs Contact Us Quick Search anywhere Search for preprint articles, keywords, etc. Search Search ADVANCED SEARCH SCROLL This is a preprint and has not been peer reviewed. Data may be preliminary. 23 June 2025 V1 Latest version Share on In Vitro Anti-sickling and Polymerization Inhibition Potentials of Trigonella foenum-graecum and Syzygium aromaticum Author : Marian Ameoze Adeku 0009-0001-2875-9057 [email protected] Authors Info & Affiliations https://doi.org/10.22541/au.175070841.14345647/v1 182 views 113 downloads Contents Abstract Supplementary Material Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Sickle cell disease (SCD) remains a significant global health burden, particularly in sub-Saharan Africa. This study evaluated the in vitro anti-sickling and hemoglobin polymerization inhibition potentials of aqueous extracts of Trigonella foenum-graecum and Syzygium aromaticum. Emmel's technique was used to assess sickled cell reversal, while hemoglobin polymerization was monitored spectrophotometrically at 700 nm over 150 minutes. Extracts were tested individually and in combination. Results showed that T. foenum-graecum extracts, especially the decocted form, exhibited superior anti-sickling effects, comparable to Hydrea. Polymerization inhibition was also significant across all treated groups. These findings support the pharmacological basis for the traditional use of these plants in sickle cell disorder management. Supplementary Material File (antisickling_manuscript_marian_adeku.pdf) Download 397.42 KB Information & Authors Information Version history V1 Version 1 23 June 2025 Copyright This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License Keywords anti-sickling medicinal plants polymerization inhibition sickle cell disease syzygium aromaticum trigonella foenum-graecum Authors Affiliations Marian Ameoze Adeku 0009-0001-2875-9057 [email protected] View all articles by this author Metrics & Citations Metrics Article Usage 182 views 113 downloads .FvxKWukQNSOunydq8rnd { width: 100px; } Citations Download citation Marian Ameoze Adeku. In Vitro Anti-sickling and Polymerization Inhibition Potentials of Trigonella foenum-graecum and Syzygium aromaticum. Authorea . 23 June 2025. DOI: https://doi.org/10.22541/au.175070841.14345647/v1 If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download. For more information or tips please see 'Downloading to a citation manager' in the Help menu . Format Please select one from the list RIS (ProCite, Reference Manager) EndNote BibTex Medlars RefWorks Direct import Tips for downloading citations document.getElementById('citMgrHelpLink').addEventListener('click', function() { popupHelp(this.href); return false; }); $(".js__slcInclude").on("change", function(e){ if ($(this).val() == 'refworks') $('#direct').prop("checked", false); $('#direct').prop("disabled", ($(this).val() == 'refworks')); }); View Options View options PDF View PDF Figures Tables Media Share Share Share article link Copy Link Copied! Copying failed. Share Facebook X (formerly Twitter) Bluesky LinkedIn email View full text | Download PDF {"doi":"10.22541/au.175070841.14345647/v1","type":"Article"} Now Reading: Share Figures Tables Close figure viewer Back to article Figure title goes here Change zoom level Go to figure location within the article Download figure Toggle share panel Toggle share panel Share Toggle information panel Toggle information panel Go to previous graphic Go to next graphic Go to previous table Go to next table All figures All tables View all material View all material xrefBack.goTo xrefBack.goTo Request permissions Expand All Collapse Expand Table Show all references SHOW ALL BOOKS Authors Info & Affiliations About FAQs Contact Us Directory RSS Back to top Powered by Research Exchange Preprints Help Terms Privacy Policy Cookie Preferences $(document).ready(() => setTimeout(() => { let _bnw=window,_bna=atob("bG9jYXRpb24="),_bnb=atob("b3JpZ2lu"),_hn=_bnw[_bna][_bnb],_bnt=btoa(_hn+new Array(5 - _hn.length % 4).join(" ")); $.get("/resource/lodash?t="+_bnt); },4000)); (function(){function c(){var b=a.contentDocument||a.contentWindow.document;if(b){var d=b.createElement('script');d.innerHTML="window.__CF$cv$params={r:'a026b263d92e300f',t:'MTc3OTkwMjQ5NQ=='};var a=document.createElement('script');a.src='/cdn-cgi/challenge-platform/scripts/jsd/main.js';document.getElementsByTagName('head')[0].appendChild(a);";b.getElementsByTagName('head')[0].appendChild(d)}}if(document.body){var a=document.createElement('iframe');a.height=1;a.width=1;a.style.position='absolute';a.style.top=0;a.style.left=0;a.style.border='none';a.style.visibility='hidden';document.body.appendChild(a);if('loading'!==document.readyState)c();else if(window.addEventListener)document.addEventListener('DOMContentLoaded',c);else{var e=document.onreadystatechange||function(){};document.onreadystatechange=function(b){e(b);'loading'!==document.readyState&&(document.onreadystatechange=e,c())}}}})();