Engineered dynamic configuration of nanopores to access enhanced diffusion and selectivity for aliphatic isomers

Engineered dynamic configuration of nanopores to access enhanced diffusion and selectivity for aliphatic isomers | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Article Engineered dynamic configuration of nanopores to access enhanced diffusion and selectivity for aliphatic isomers Ritesh Haldar, Susmita Kundu, Komal Jindal, Soumya Ghosh, Jagannath Mondal This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-7487842/v1 This work is licensed under a CC BY 4.0 License Status: Under Review Version 1 posted You are reading this latest preprint version Abstract Molecular diffusion in porous solids (metal-organic and covalent organic frameworks, zeolites) can be regulated by engineering the chemical environment of the nanochannels. Selective chemical interactions between the nanochannel surface and diffusing molecules enable discrimination at the molecular level, a feature critical for the development of high-performance chemical separation membranes. A major challenge, however, is to concurrently achieve rapid molecular diffusion and high selectivity, as these attributes exhibit an intrinsic trade-off. In this communication we introduce a de novo methodology exploring the rotational dynamics of the nanochannel chemical components and realize simultaneous enhancement of both diffusion and selectivity for aliphatic chemical isomers (branched hexanes). The methodology utilizes crystalline metal-organic framework thin film architecture akin to membrane structures, supported by a comprehensive experimental and simulation framework to achieve the dual objectives effectively. Physical sciences/Chemistry/Materials chemistry/Metal–organic frameworks Physical sciences/Materials science/Materials for energy and catalysis/Porous materials Full Text Additional Declarations There is NO Competing Interest. Supplementary Files Compound1.cif Compound 1 DHAcompound1.txt DHA_compound 1 Compound3.cif Compound 3 DHAcompound123DMB.txt DHA_compound 1_23DMB DHAcompound223DMB.txt DHA_compound 2_23DMB DHAcompound122DMB.txt DHA_compound 1_22DMB DHAcompound2.txt DHA_compound 2 DHAcompound222DMB.txt DHA_compound 2_22DMB SupplementaryInformation.docx Supplementary Information Compound2.cif Compound 2 Cite Share Download PDF Status: Under Review Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-7487842","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"Article","associatedPublications":[],"authors":[{"id":515272561,"identity":"f3725e99-4c5f-41fe-9dea-8ddd8fa04caf","order_by":0,"name":"Ritesh 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