Comparative Effect of Chemotherapy and Non-chemotherapy Treatments on the Survival of Breast Cancer Patients at Different Stages: A SEER Cross-Sectional Based Study

Comparative Effect of Chemotherapy and Non-chemotherapy Treatments on the Survival of Breast Cancer Patients at Different Stages: A SEER Cross-Sectional Based Study | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Comparative Effect of Chemotherapy and Non-chemotherapy Treatments on the Survival of Breast Cancer Patients at Different Stages: A SEER Cross-Sectional Based Study Sonia Kaindal, Venkataramana B This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-3859118/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract The primary cause of fatalities due to cancer in women is breast cancer. The research’s objective is to determine the comparative effect of chemotherapy and non-chemotherapy on breast cancer outcomes observed in patients at different stages. The study aimed to clarify the potential differences in treatment effectiveness depending on the cancer stage. A total of 446,806 cancer patients were contained in the data set. Between 2011 and 2015 years 316,557 cancer patients were found. Chi-square tests were conducted to analyze statistical differences in demographic characteristics and clinical results between chemotherapy and non-chemotherapy patients. Kaplan-Meier analysis and log-rank tests are used to evaluate the results of different types of treatment. Multiple Cox regression was used to compare the overall and specific survival. In the model, the relationship between the patient’s marital status, age, race, tumor type, ER, PR, HER2, nodes, and primary locations have significantly influenced the overall survival rate (OS) and the specific survival rate (BCSS) for breast cancer in contrast to mastectomy. Chemotherapy significantly lowers the death rate in both overall survival (OS) and breast cancer-specific survival (BCSS) (HR=0.719, 95 percent CI=0.696-0.743; OS: HR=0.519, 95 percent CI=0.507-0.532, p<0.001). We observed that married patients receiving chemotherapy have significantly improved survival, highlighting the potential impact of marriage on prognosis. Analysis used secondary data available from the Surveillance, Epidemiology, and End Results (SEER) database. Multivariate Regression Breast Cancer Chemotherapy Survival Analysis SEER database Full Text Additional Declarations No competing interests reported. Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-3859118","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":266817141,"identity":"398c6426-5f72-47b8-88a1-487a7d739982","order_by":0,"name":"Sonia Kaindal","email":"","orcid":"","institution":"Vellore Institute of Technology","correspondingAuthor":false,"prefix":"","firstName":"Sonia","middleName":"","lastName":"Kaindal","suffix":""},{"id":266817142,"identity":"73e7e015-9064-41cd-9f07-2fb119b8bf7c","order_by":1,"name":"Venkataramana B","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAABB0lEQVRIiWNgGAWjYHACZmTOATkYnwe/lgSEFmMGZmYStSQ2oFqLCQyO9x42+PnDLp9/2uFnD34w3EnfcJz/AMOPGgYZc1xazpxLTuxJSLaccTvN3LCH4VnuhsPMDIw9xxh4LBuwa5GckWN8gCeB2YDhdoKZBA/D4dyZzUCH8TYw8BgcwKFl/hvjg38S6g3kb6d/k/zDcDhdEqiF8S8eLfwSPMbJPAmHDQxu55hJA21J4AeGGDM+W/h5coyNZdKOGxjezimTljF4ZtjPzGxwWOaYBE4tbOxnjCXf2FQbyN1O3yb5puKOPBv/wYcP39TY2OPSggYMIBRQsQRR6kfBKBgFo2AUYAcA4VhRJrMn4u0AAAAASUVORK5CYII=","orcid":"","institution":"Vellore Institute of Technology","correspondingAuthor":true,"prefix":"","firstName":"Venkataramana","middleName":"","lastName":"B","suffix":""}],"badges":[],"createdAt":"2024-01-13 05:29:13","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-3859118/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-3859118/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":49842593,"identity":"f179c8df-631d-41da-b324-8bc68240db18","added_by":"auto","created_at":"2024-01-19 00:22:55","extension":"pdf","order_by":1,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":789485,"visible":true,"origin":"","legend":"","description":"","filename":"Manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-3859118/v1_covered_9656fca8-97a4-4f0c-8f97-14c66a8e0e98.pdf"}],"financialInterests":"No competing interests reported.","formattedTitle":"Comparative Effect of Chemotherapy and Non-chemotherapy Treatments on the Survival of Breast Cancer Patients at Different Stages: A SEER Cross-Sectional Based Study","fulltext":[],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":true,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"Multivariate Regression, Breast Cancer, Chemotherapy, Survival Analysis, SEER database","lastPublishedDoi":"10.21203/rs.3.rs-3859118/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-3859118/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"The primary cause of fatalities due to cancer in women is breast cancer. The research’s objective is to determine the comparative effect of chemotherapy and non-chemotherapy on breast cancer outcomes observed in patients at different stages. The study aimed to clarify the potential differences in treatment effectiveness depending on the cancer stage. A total of 446,806 cancer patients were contained in the data set. Between 2011 and 2015 years 316,557 cancer patients were found. Chi-square tests were conducted to analyze statistical differences in demographic characteristics and clinical results between chemotherapy and non-chemotherapy patients. Kaplan-Meier analysis and log-rank tests are used to evaluate the results of different types of treatment. Multiple Cox regression was used to compare the overall and specific survival. In the model, the relationship between the patient’s marital status, age, race, tumor type, ER, PR, HER2, nodes, and primary locations have significantly influenced the overall survival rate (OS) and the specific survival rate (BCSS) for breast cancer in contrast to mastectomy. Chemotherapy significantly lowers the death rate in both overall survival (OS) and breast cancer-specific survival (BCSS) (HR=0.719, 95 percent CI=0.696-0.743; OS: HR=0.519, 95 percent CI=0.507-0.532, p\u003c0.001). We observed that married patients receiving chemotherapy have significantly improved survival, highlighting the potential impact of marriage on prognosis. Analysis used secondary data available from the Surveillance, Epidemiology, and End Results (SEER) database.","manuscriptTitle":"Comparative Effect of Chemotherapy and Non-chemotherapy Treatments on the Survival of Breast Cancer Patients at Different Stages: A SEER Cross-Sectional Based Study","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2024-01-16 02:05:58","doi":"10.21203/rs.3.rs-3859118/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"104d70af-2709-4360-a590-47008164ff7f","owner":[],"postedDate":"January 16th, 2024","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[],"tags":[],"updatedAt":"2024-01-20T10:59:37+00:00","versionOfRecord":[],"versionCreatedAt":"2024-01-16 02:05:58","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-3859118","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-3859118","identity":"rs-3859118","version":["v1"]},"buildId":"qtupq5eGEP_6zYnWcrvyt","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}