A food supplement having Adiponectin Agonist properties

Objective: Present work was planned to study the clinical effects of Adipomimetin tablets on human beings having Type-II diabetes. Research Methods &Procedures: Tablets were prepared with 40mg and 80mg of Adipomimetin per tablet. They were administered to diabetic patients as an ‘ add-on ’ to standard-of-care therapy that was stabilized for each patient enrolled; and also to a small group of patients which were diagnosed for the first time as diabetic and had not been started on any medicine. Results The findings on ability of Adipomimetin for normalizing blood sugar and hypertension over and above the effect of Standard-of-Care therapy were confirmed in a CTRI registered prospective clinical trial.Statistically highly significant reduction at P < 0.0001 in HbA1c, Fasting and Post Prandinal blood sugar, Systolic blood pressure, body weight, BMI, Diastolic blood pressure at P = 0.0319 and increase in Muscle % at P = 0.0318 was noted. Although overall reduction in body fat was insignificant statistically (P > 0.05), in individuals that had high body fat, reduction in the same was observed.The observations point out tohormonal action ofAdipomimetinas an agonist of Adiponectinthat substantially restores the homeostasis of metabolism to normal level so that its anti-pathogenesis action, i.e. action against genesis of disease, is anti-Metabolic-Syndrome-genesis,rather than a medicinal action that modifies body/metabolism to control the symptoms of diseases after the disease is precipitated. Adipomimetin, a nutraceutical/food supplement, has shown its capability to cover the scope of recovery that has not been covered by State-of-Artmedicinal treatment for above clinical parameters. There was no difference in efficacy between 40mg and 80mg active. Conclusion The “water insoluble concentrated mass substantially free from components more soluble in the plant juice” – the Adipomimetin, displays Adiponectin Agonist properties useful to overcome deficiency of Adiponectin and to augment all benefits expected from an Adiponectin Agonist at 40mg active three times a day.