RELATIONSHIPS BETWEEN SPECIFIC INFERTILITY DIAGNOSES AND FERTILITY QUALITY OF LIFE (FERTIQOL), INSOMNIA, AND PERCEIVED STRESS DURING COVID-19 PANDEMIC

Fertility and sterility · 2020 · PMC7548653
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Among 220 Manhattan fertility patients, infertility diagnosis etiology including endometriosis did not significantly impact Fertility Quality of Life, insomnia, or stress levels during the COVID-19 pandemic, regardless of treatment discontinuation.

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This study surveyed 220 patients at a Manhattan fertility clinic to assess how specific infertility diagnoses, including endometriosis, influenced Fertility Quality of Life, insomnia, and perceived stress during the COVID-19 pandemic. Researchers utilized multiple linear regression to analyze relationships between diagnostic categories and psychometric scores, while also comparing patients who discontinued treatment versus those who continued. The analysis revealed no statistically significant association between the specific etiology of infertility and any of the measured quality of life or stress outcomes. Additionally, treatment discontinuation due to the pandemic did not result in significantly different FertiQol scores compared to uninterrupted care. Relevance to endometriosis: listed as one indication for GnRH antagonists, though the paper's main focus is uterine fibroids.

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Design

Surveys were administered to 220 patients at a fertility clinic in Manhattan during the COVID-19 pandemic. The surveys included a 36-item FertiQol questionnaire assessing Fertility Quality of Life in men and women experiencing fertility problems. The surveys also asked patients to specify their infertility diagnoses (polycystic ovary syndrome, diminished ovarian reserve, uterine factor, endometriosis, or male infertility). Patients were further given a 7-item ISI questionnaire and a 10-item PSS questionnaire. Finally, the surveys asked whether patients were forced to disrupt their fertility treatment plans due to the COVID-19 pandemic.

Results

The majority of the IVF patients sampled self-reported moderate stress (66.9%). There was no statistically significant relationship between the exact etiology of an IVF patient’s infertility diagnosis and the patient’s FertiQol score. There was also no statistically significant relationship between the exact etiology of an IVF patient’s infertility diagnosis and the patient’s ISI nor PSS scores. Patients who discontinued their fertility treatments during COVID-19 did not have different FertiQol scores from patients who were able to continue.

Materials

Using multiple linear regression, we looked for statistically significant relationships between different infertility diagnoses and FertiQol scores. For this regression, we excluded all individuals who did not know their infertility diagnosis, had unexplained infertility issues, answered that they were fertile, or did not answer the FertiQol questionnaire. We also used multiple linear regression to look for statistically significant relationships between different infertility diagnoses and levels of insomnia and between different infertility diagnoses and perceived stress. Next, using Welch’s t-test, we investigated if patients who discontinued their fertility treatments during the COVID-19 pandemic had a different mean FertiQol score from patients who continued treatment. We excluded all individuals who were not currently undergoing treatment and who did not answer the FertiQol questionnaire. A p-value less than 0.05 was considered statistically significant.

Objective

The objective of this study was to determine if different infertility diagnoses impacted patients’ scores on the FertiQol questionnaire, Insomnia Severity Index (ISI), and Perceived Stress Scale (PSS) during the COVID-19 pandemic. The study also investigated if patients who were forced to discontinue their fertility treatment during the COVID-19 pandemic had different FertiQol scores than patients who were able to continue.

Conclusions

The majority of the IVF patients sampled self-reported moderate stress during the COVID-19 pandemic. Interestingly, the exact etiology of an IVF patient’s infertility diagnosis did not have a statistically significant impact upon his or her Fertility Quality of Life, ISI, and PSS scores during this time period. Patients who were forced to discontinue their fertility treatments due to COVID-19 did not have different FertiQol scores from patients who were able to continue.

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last seen: 2026-11-01T09:25:17.647243+00:00