Notch1 Signaling Contributes to Mechanical Allodynia Associated with Cyclophosphamide‐Induced Cystitis by Promoting Microglia Activation and Neuroinflammation

Jialiang Chen; Honglu Ding; Bolong Liu; Xiangfu Zhou; Xin Zhou; Zhijun Lin; Fei Yang; Hailun Zhan; Hengjun Xiao

doi:10.1155/2021/1791222

Notch1 Signaling Contributes to Mechanical Allodynia Associated with Cyclophosphamide‐Induced Cystitis by Promoting Microglia Activation and Neuroinflammation

Jialiang Chen, Honglu Ding, Bolong Liu, Xiangfu Zhou, Xin Zhou, Zhijun Lin, Fei Yang, Hailun Zhan, Hengjun Xiao

In: Mediators of Inflammation · 2021 · vol. 2021(1) , pp. 1791222 · doi:10.1155/2021/1791222 · PMID:34646085 · W3203689310

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Notch1 signaling contributes to mechanical allodynia in cyclophosphamide-induced cystitis by promoting microglia activation and neuroinflammation.

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Abstract

AIMS: Notch1 signaling regulates microglia activation, which promotes neuroinflammation. Neuroinflammation plays an essential role in various kinds of pain sensation, including bladder-related pain in bladder pain syndrome/interstitial cystitis (BPS/IC). However, the impact of Notch1 signaling on mechanical allodynia in cyclophosphamide- (CYP-) induced cystitis is unclear. This study is aimed at determining whether and how Notch1 signaling modulates mechanical allodynia of CYP-induced cystitis. METHODS: in the L6-S1 spinal dorsal horn (SDH) was measured with Western blotting analysis and immunofluorescence staining. RESULTS: . CONCLUSION: Notch1 signaling contributes to mechanical allodynia associated with CYP-induced cystitis by promoting microglia activation and neuroinflammation. Our study showed that inhibition of Notch1 signaling might have therapeutic value for treating pain symptoms in BPS/IC.

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