Each of the twenty amino acids in the codon dictionary has its own numerical value

Each of the twenty amino acids in the codon dictionary has its own numerical value | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Article Each of the twenty amino acids in the codon dictionary has its own numerical value Brenda K Krkosska Bayles, Charles M. Heckert This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-3706624/v1 This work is licensed under a CC BY 4.0 License Status: Under Review Version 1 posted 13 You are reading this latest preprint version Abstract A codon’s three bases consist of any combination of uracil, cytosine, adenine, or guanine and these encode the twenty amino acids. When the codon’s first two bases are given specific values, and those values are multiplied, then the third base of the codon is used during translation only when the product is greater than three. Here we show that those values plus more variables within the ribosomal decoding site results in specific flow values for each of the twenty amino acid groups. These results are demonstrated in a flow chart showing the unidirectional flow which is expected during the translation process. All twenty amino acids can be represented by numbers that describe their relationship to each other and to the decoding site. We anticipate our findings will increase discussion about using a number system to better understand the translation process. Biological sciences/Biochemistry Biological sciences/Biophysics Biological sciences/Biotechnology Biological sciences/Cell biology Biological sciences/Chemical biology Biological sciences/Genetics Biological sciences/Molecular biology Full Text Additional Declarations No competing interests reported. Cite Share Download PDF Status: Under Review Version 1 posted Editorial decision: Revision requested 10 Jun, 2024 Reviews received at journal 23 May, 2024 Reviewers agreed at journal 11 May, 2024 Reviews received at journal 06 May, 2024 Reviews received at journal 30 Apr, 2024 Reviewers agreed at journal 30 Apr, 2024 Reviewers agreed at journal 22 Apr, 2024 Reviewers agreed at journal 26 Feb, 2024 Reviewers invited by journal 22 Feb, 2024 Editor assigned by journal 29 Jan, 2024 Editor invited by journal 21 Jan, 2024 Submission checks completed at journal 21 Jan, 2024 First submitted to journal 04 Dec, 2023 You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. 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