Catamenial pneumothorax after multiple failed in vitro fertilization cycles

Bojan Milačić, O Vujadinović, Batrić Vukčević, Petar Milić
In: Vojnosanitetski pregled · 2019 · vol. 78(5) , pp. 575–578 · doi:10.2298/vsp190806100m · W2973101071
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This case report describes a woman with catamenial pneumothorax after failed IVF cycles, treated with surgery and GnRH agonist, suggesting ovarian hyperstimulation may have contributed.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-08 · read from full text ⓘ

This paper is a case report of a 42-year-old woman with pelvic endometriosis who developed a complete right catamenial pneumothorax on the first day of menstrual bleeding after 7 failed in vitro fertilization cycles. High-level workup included chest radiography showing the pneumothorax and video-assisted thoracoscopic surgery, which identified pulmonary bullous lesions and a diaphragmatic fenestration; histopathology of resected pulmonary tissue was negative for endometriosis, and postoperative treatment included a 6-month course of the GnRH agonist triptorelin. The authors propose that ovarian hyperstimulation from IVF may have contributed to rupture of bullae and/or activation of endometriotic diaphragmatic fenestrations, while noting that pulmonary endometriosis was not confirmed histologically. This paper is centrally about endometriosis — it reports catamenial pneumothorax in a patient with known pelvic endometriosis and discusses potential thoracic diaphragmatic endometriosis as part of the mechanism.

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Abstract

Introduction. Catamenial pneumothorax is spontaneous pneumothorax occurring within 72?96 h before and after menstrual bleeding. It is frequently associated with thoracic endometriosis. However, certain cases are not associated with any identifiable thoracic pathology. Case report. A 42-year-old woman with a history of pelvic endometriosis presented with sudden cough and shortness of breath on the first day of menstrual bleeding. Chest radiography revealed a complete right pneumothorax. The patient had previously undergone 7 failed in vitro fertilization cycles. Video-assisted thoracoscopic surgery showed pulmonary bullous lesions and a diaphragmatic fenestration. Atypical resection of the pulmonary apex was performed by an endostapler. Diaphragm plication was performed using Ethibond sutures. Definitive histopathological examination of the pulmonary tissue was negative for endometriosis. A postoperative course of gonadotropin-releasing hormone (GnRH) agonist triptorelin was administered during a period of 6 months. The patient's postoperative recovery was uneventful, without recurrence of pneumothorax to this day. Conclusion. There is a possibility that ovarian hyperstimulation caused the rupture of the pulmonary bullae. The patient may have developed endometriotic diaphragmatic fenestrations, activated by ovarian hyperstimulation, leading to pneumothorax. Early diagnosis and timely surgical treatment dealing with all thoracic pathology, as well as adjuvant hormonal treatment, may reduce the recurrence rate of catamenial pneumothorax.
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Vojnosanitetski pregled 2021 Volume 78, Issue 5, Pages: 575-578 Catamenial pneumothorax after multiple failed in vitro fertilization cycles Milačić Bojan (Clinical Center of Montenegro, Center for Thoracic Surgery, Podgorica, Montenegro + University of Montenegro, Faculty of Medicine, Podgorica, Montenegro), [email protected] Introduction. Catamenial pneumothorax is spontaneous pneumothorax occurring within 72–96 h before and after menstrual bleeding. It is frequently associated with thoracic endometriosis. However, certain cases are not associated with any identifiable thoracic pathology. Case report. A 42-year-old woman with a history of pelvic endometriosis presented with sudden cough and shortness of breath on the first day of menstrual bleeding. Chest radiography revealed a complete right pneumothorax. The patient had previously undergone 7 failed in vitro fertilization cycles. Video-assisted thoracoscopic surgery showed pulmonary bullous lesions and a diaphragmatic fenestration. Atypical resection of the pulmonary apex was performed by an endostapler. Diaphragm plication was performed using Ethibond sutures. Definitive histopathological examination of the pulmonary tissue was negative for endometriosis. A postoperative course of gonadotropin-releasing hormone (GnRH) agonist triptorelin was administered during a period of 6 months. The patient's postoperative recovery was uneventful, without recurrence of pneumothorax to this day. Conclusion. There is a possibility that ovarian hyperstimulation caused the rupture of the pulmonary bullae. The patient may have developed endometriotic diaphragmatic fenestrations, activated by ovarian hyperstimulation, leading to pneumothorax. Early diagnosis and timely surgical treatment dealing with all thoracic pathology, as well as adjuvant hormonal treatment, may reduce the recurrence rate of catamenial pneumothorax. Keywords: catamenial pneumothorax, fertilization in vitro, endometriosis, thoracic surgery, video-assisted https://doi.org/10.2298/VSP190806100M Full text ( 328 KB) Cited by Vujadinović Obrad (Clinical Center of Montenegro, Center for Thoracic Surgery, Podgorica, Montenegro) Vukčević Batrić (University of Montenegro, Faculty of Medicine, Podgorica, Montenegro) Milić Petar (General Hospital Kotor, General Surgery Department, Kotor, Montenegro)

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