Effect of different anesthesia methods on inflammation and oxidative stress in patients with laparoscopic hysterectomy

Objective: To analyze the effect of different anesthesia methods on inflammation and oxidative \nstress in patients with laparoscopic hysterectomy. Methods: A total of 75 cases who received \nlaparoscopic hysterectomy in our hospital from September 2012 to February were included \nin the research and divided into simple general anesthesia group 40 cases and combined \ngeneral and epidural anesthesia group 35 cases according to different anesthesia methods. \nPeripheral venous blood was drawn from patients to detect the differences in inflammationrelated indexes, immune molecule-related indexes, cerebral oxygen metabolism as well as \ncerebral blood flow and oxidative stress-related indexes, etc in it. Results: Postoperative MBP, \nMCP-1, HMGB1 and LBP values of observation group were lower than those of control group \nwhile Ins value was higher than that of control group (P<0.05);postoperative CD25,CD14, \nCD4+CD25+T,CD8+CD28-T and Th1 cell percentage of observation group were higher than \nthose of control group while Th2 cell, Th17 cell percentage were lower than those of control \ngroup (P<0.05); CaO2, CjvO2 and CajvDO2 values of observation group 30 min before the end \nof operation and after operation were higher than those of control group (P<0.05); serum 5-HT, \nTH and MAOA values of observation group after treatment were lower than those of control \ngroup while GSH-Px and T-AOC values were higher than those of control group (P<0.05). \nConclusions: Combined general and epidural anesthesia for patients with laparoscopic \nhysterectomy can effectively inhibit body's inflammatory and oxidative stress state and \nmaintain stable immune state, and it has positive clinical significance.