Usage of methods diffuse Mueller-matrix introscopy for early diagnosis of endometriosis based on study of dehydrated films of peritoneal fluid

The aim of the study. To evaluate the effectiveness of early diagnosis of endometriosis using the methods of diffuse Mullermatrix endoscopy of scattering dehydrated films of peritoneal fluid. Material and methods. Two groups of samples were studied: peritoneal fluid obtained during diagnostic laparoscopy – control group 3.1 – 68 samples; peritoneal fluid obtained during diagnostic laparoscopy in women with endometriosis associated with infertility – experimental group 3.2 – 59 samples. Results. Detected the presence of fluctuations in the amount of circular birefringence of the supramolecular polycrystalline chiral structure of leukocytes in the peritoneal fluid films of patients from all groups; increase in the magnitude of fluctuations of circular birefringence of supramolecular structures of peritoneal fluid samples of patients with endometriosis; the correlation of changes in the optically active (chiral) structure of supramolecular networks of leukocytes in the peritoneal fluid and the growth of circular birefringence fluctuations in endometriosis; diagnostic and statistically reliable markers of the pathological process and the effectiveness of the treatment of endometriosis - the values of the average and dispersion, which characterize the distribution of the fluctuations of the circular birefringence. pi=1;2;3;4  0,05 Conclusions. By means of statistical analysis of a series of thesiograms of coordinate distributions of random values of fluctuations in the amount of variations in the optical anisotropy of biological preparations, additional markers for early diagnosis of endometriosis were experimentally established. Linear birefringence – good (88.1% – 89.7%) diagnostic accuracy - groups 3.1–3.2; circular birefringence – excellent (96.8% – 97.4%) and very good (92.9% – 93.7%) diagnostic accuracy – groups 3.1–3.2; linear dichroism – very good (90.5% – 92.1%) diagnostic accuracy – groups 3.1–3.2; circular dichroism – very good (89.8% – 92.1%) diagnostic accuracy – groups 3.1–3.2. SM SM SM SM SM SM SM SM SM SM SM SM SM SM 1 1 1 2 3 4 1 2 3 4 1 2 3 4