Expression of Human β Defensin-2 in Eutopic and Ectopic Endometrium of Women with Endometriosis

【Objective】 To investigate the expression of human β defensin-2(hBD-2) in the eutopic and ectopic endometrium of women with ovarian endometriosis and explore the role of hBD-2 in the pathogenesis of endometriosis.【Methods】 Twenty-five women with ovarian endometriosis and 25 controls were studied.Expression of hBD-2 was investigated quantitatively using real-time PCR and in-situ hybridization.Expression of hBD-2 was compared in the eutopic and ectopic endometrium of different clinical stage.【Results】 hBD-2 gene expression was significantly stronger in the ectopic endometrium group than that in the eutopic endometrium group and the control group(P 0.05),but there were no significant difference between the control group and the eutopic endometrium group.In the ectopic endometrium group,hBD-2 expression in the first stage and second stage were obviously stronger than that in the third stage and forth stage(P 0.05),respectively.【Conclusion】 Up-regulated expression of hBD-2 might play a pathogenic role in the formation of endometriosis.