Nitric oxide (NO) level of the follicular fluid in endometriosis patients
This study found higher nitric oxide (NO) levels in the follicular fluid of endometriosis patients compared to non-endometriosis patients, with specific genetic polymorphisms linked to increased NO and reduced fertility.
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The study compared nitric oxide (NO) levels in follicular fluid from 54 women with endometriosis versus tubectomy controls without endometriosis, with sampling during laparoscopy and tubectomy respectively, and measured NO using PCR-RFLP with STATA for analysis. NO levels were higher in the endometriosis group, and NO showed significant relationships with age, parity, dysmenorrhea, dyspareunia, type of endometriosis, and endometriosis grade. The authors also report that allele GG polymorphism was more frequent in endometriosis and, in their interpretation, is associated with higher eNOS and increased NO that may contribute to reduced fertility via degenerative oocytes. This paper is centrally about endometriosis — it measures follicular fluid nitric oxide levels and related eNOS polymorphism in women with endometriosis compared with non-endometriosis controls.
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- Female Infertility and Free Radicals: Potential Role in Adhesions and Endometriosis via openalex
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