The Impact of Hemp Seed Oil on Drug-Drug Interactions: A Comprehensive Review of Potential Mechanisms and Clinical Implications

Abstract Hemp seed oil (HSO), esteemed for its potential health benefits and therapeutic attributes, has garnered substantial attention in recent years. However, the escalating consumption of HSO has engendered apprehensions regarding its potential interactions with pharmaceutical medications, posing the risk of adverse effects or altered drug efficacy. This comprehensive review diligently explores and elucidates the underlying mechanisms through which HSO may interact with a spectrum of drugs, accompanied by an extensive assessment of the clinical ramifications of these interactions. By assiduously unraveling these intricate dynamics, this review equips healthcare professionals and consumers with the knowledge to make judicious decisions concerning the concurrent use of HSO and prescription medications. Moreover, this comprehensive review endeavors to identify and address research gaps, charting a route for future investigations in this critical domain. This review sheds light on HSO's impact on drug-drug interactions (DDIs), delivering invaluable insights for healthcare professionals, researchers, and consumers and fostering the responsible and informed incorporation of this natural product across diverse therapeutic contexts.