Suggested Markers for the Diagnosis of Endometriosis
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This paper hypothesizes that immune system regulation by cytokines influences endometriosis pathophysiology, suggesting a potential diagnostic tool bypassing surgery.
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Abstract
Endometriosis is a multifactorial and enigmatic disease since the causal clusters of conditions leading to one of the four stages of the malady comprise, but are not limited to, anatomical, pathological, genetic and immunological dysfunctions. Since the early 80s, immunologic parameters appear associated with the evolving entity of the disease influencing directly or indirectly the pathophysiology factor(s) implicated. We hereby propose a hypothesis on how regulation of the immune system by cytokines and other molecules actively participating in immune conditioning and reactions, sets the conditions for the manifestation of the disease and also how this information may lead to a novel diagnostic evaluation tool bypassing surgery. Keywords: Endometriosis, cytokines, IL-12, IL-15, IL-18, IFN-γ, VEGF
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Cited by (6)
- Blood biomarkers for the non-invasive diagnosis of endometriosis 2016
- Non-invasive tests for the diagnosis of endometriosis 2012
- Can Incapacitation of the Mesenchymal Endometriotic Stem Cell via the Fortification of the Immune System Lead to the Eradication of Endometriosis? 2011
- Premature Immunosenescence Impairs Immune Surveillance Allowing the Endometriotic Stem Cell to Migrate: The Cytokine Profile as a Common Denominator 2010
- Premature immunosenescence impairs immune surveillance allowing the endometriotic stemcell to migrate: The cytokine profile as a common denominator 2010
- Different HLA-DR expression in endometriotic and adenomyotic lesions: correlation with transvaginal ultrasonography findings 2009
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