The relation between the expression of cytokines and the degree of pelvic adhesions in endometriosis

Objective To investigate the expression of cytokines TNF-a,IL-6 and IL-8 in endometriosis and its correlation with the degree of pelvic adhesions.Methods 50 patients with endometriosis were selected.The TNF-a,IL-6,IL-8 in serum before operation and 3 months after operation and in peritoneal fluid got intra-operation were detected by ELISA.The correlation with adhesions analyzed.Results 41 cases(80.2%)had different degree of pelvic adhesions,and TNF-α,IL-6 and IL-8 in serum and peritoneal fluid were significantly higher than those in the control group(P0.05).TNF-alpha,IL-6 and IL-8 in peritoneal fluid in patients with stage Ⅲ~Ⅳ was significantly higher than in those with Ⅰ~Ⅱ stage.The TNF-ain patients with stage Ⅰ-Ⅱ was significantly higher than those in the control group(P0.05);TNF-α,IL-6 and IL-8 in serum 3 months after operation were significantly decreased compared to those before operation(P0.05).Pelvic adhesion degree and IL-6,IL-8,TNF-ain peritoneal fluid were positively correlated(r=0.457,r=0.336,r=0.263,P0.05);preoperative serum cytokines except IL-8(r=0.135,P0.05),TNF-α,IL-6 was positively associated with adhesions(r=0.521,r=0.470,P0.05).Contusion Cytokines TNF-α,IL-6 and IL-8 were closely related to the clinical stage and therapeutic efficacy in the treatment of endometriosis.The change of TNF-α,IL-6 and IL-8 in endometriosis was an important index to preoperative evaluation,therapeutic evaluation and recurrence.