The Use of Natural Agents to Counteract Telomere Shortening: Effects of a Multi-Component Extract of Astragalus mongholicus Bunge and Danazol

Isabelle Guinobert, Claude Blondeau, Bruno Colicchio, Noufϊssa Oudrhiri, Alain Dieterlen, Éric Jeandidier, Georges Deschênes, Valérie Bardot, César Cotte, Isabelle Ripoche, Patrice Carde, Lucile Berthomier, Radhia M’kacher
In: Biomedicines · 2020 · vol. 8(2) , pp. 31 · doi:10.3390/biomedicines8020031 · PMID:32059353 · W3006643068
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A multi-component extract of Astragalus mongholicus Bunge significantly elongated telomeres in peripheral blood lymphocytes from healthy donors, demonstrating less toxicity than danazol and suggesting potential for managing age-related diseases.

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Abstract

Bunge and assessed its effects on telomeres compared to those of danazol. Astragalosides I to IV, flavonoids, amino acids and sugars were detected in the HRE. Samples of peripheral blood lymphocytes with short telomeres from 18 healthy donors (mean age 63.5 years; range 3286 years) were exposed to a single dose of 1 µg/mL HRE or danazol for three days. Telomere length and telomerase expression were then measured. Significant elongation of telomeres associated to a less toxicity was observed in lymphocytes from 13/18 donors following HRE treatment (0.54 kb (0.15-2.06 kb)) and in those from 9/18 donors after danazol treatment (0.95 kb (0.06-2.06 kb)). The rate of cells with short telomeres (<3 kb) decreased in lymphocytes from all donors after exposure to either HRE or danazol, telomere elongation being telomerase-dependent. These findings suggest that the HRE could be used for the management of age-related diseases.

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