F04Prognostic value of Dopplerometry during antirecurrent hormonal therapy in patients with hyperplastic process of the endometrium

Background The purpose of study was to find out changes of Doppler parameters in all uterine arteries during antirecurrent hormonal courses and to define their role in prediction of outcomes. Method 53 patients receiving hormonal therapy (Norcolut, Provera, Danazol) after D & C were undergone 6 months monitoring by transvaginal ultrasound with Color Flow Mapping and Doppler assessment of the main uterine, arcuate, radial and basal arteries. The mean values of resistance indices (RI) were calculated after retrospective division into groups with effective ( n = 41) and effectless ( n = 12) treatment. Investigated RI data were used for statistical creation of prognostic upper and lower cut‐off levels (for P < 0.05). Results The resistance indices were: Healthy Effective treatment Effectless treatment Cut‐off intervals for P < 0.05 Uterine arteries 0.88 0.86 0.83 0.83–0.87 Arcuate arteries 0.78 0.74 0.72 0.65–0.80 Radial arteries 0.71 0.73* 0.65* 0.60–0.75 Basal arteries 0.57 0.62 0.57 0.48–0.68 – p < 0.10 Conclusion For predicting effectiveness of hormonal treatment after two months from its beginning Doppler measurements should be carried out in Radial Arteries and RI must exceed 0.75.