Redefining Cancer: From Elimination to Debugging

Redefining Cancer: From Elimination to Debugging | Authorea try { document.documentElement.classList.add('js'); } catch (e) { } var _gaq = _gaq || []; _gaq.push(['_setAccount', 'G-8VDV14Y67G']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 'https://ssl' : 'http://www') + '.google-analytics.com/ga.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s); })(); Skip to main content Preprints Collections Wiley Open Research IET Open Research Ecological Society of Japan All Collections About About Authorea FAQs Contact Us Quick Search anywhere Search for preprint articles, keywords, etc. Search Search ADVANCED SEARCH SCROLL This is a preprint and has not been peer reviewed. Data may be preliminary. 15 September 2025 V3 Latest version Share on Redefining Cancer: From Elimination to Debugging Author : James Oliver 0009-0003-9912-095X [email protected] Authors Info & Affiliations https://doi.org/10.22541/au.173921658.84316821/v3 463 views 154 downloads Contents Abstract Supplementary Material Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Cancer is not just a mass to remove—it is genomic disorder accumulating faster than it can be repaired. This essay reframes oncology as debugging rather than deletion: measure instability as a composite entropy index, track its rate of change, and modulate three levers—damage rate, repair capacity, and selection pressure. We pair anatomical staging (I–IV) with genomic instability to avoid conflating tumor location with system disorder. The framework is falsifiable: it fails if cancers arise without rising entropy or if entropy metrics lack predictive value. We present a mechanistic model, observable proxies, and testable predictions for those seeking to move beyond reactive elimination toward proactive stabilization. Supplementary Material File (redefining cancer.pdf) Download 98.92 KB Information & Authors Information Version history V1 Version 1 10 February 2025 V2 Version 2 28 February 2025 V3 Version 3 15 September 2025 Copyright This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License Keywords biotech cancer research dna entropy genomics medical innovation molecular biology oncology philosophy of science precision medicine systems biology Authors Affiliations James Oliver 0009-0003-9912-095X [email protected] View all articles by this author Metrics & Citations Metrics Article Usage 463 views 154 downloads .FvxKWukQNSOunydq8rnd { width: 100px; } Citations Download citation James Oliver. Redefining Cancer: From Elimination to Debugging. Authorea . 15 September 2025. DOI: https://doi.org/10.22541/au.173921658.84316821/v3 If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download. For more information or tips please see 'Downloading to a citation manager' in the Help menu . Format Please select one from the list RIS (ProCite, Reference Manager) EndNote BibTex Medlars RefWorks Direct import Tips for downloading citations document.getElementById('citMgrHelpLink').addEventListener('click', function() { popupHelp(this.href); return false; }); $(".js__slcInclude").on("change", function(e){ if ($(this).val() == 'refworks') $('#direct').prop("checked", false); $('#direct').prop("disabled", ($(this).val() == 'refworks')); }); View Options View options PDF View PDF Figures Tables Media Share Share Share article link Copy Link Copied! Copying failed. 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