n

ud 2 7 mk its to tamoxifen induced premature uterine adenomyosis and was associated with abnormal development particularly of the inner myometrium. In the present study, we examined the effect of neonatal tamoxifen administration upon uterine development in the of endometrial glands and/or stroma deep within a human primates, dogs, cats, laboratory rodents and affected, with disease severity increasing thereafter ifen to female CD-1 pups has been demonstrated to rabbits (McCann & Myers 1970, Suire et al. 1978).DOI: 10.1530/REP-09-0443In mice, its prevalence is strain dependent. In CD-1 q 2010 Society for Reproduction and Fertilityinduce the premature appearance of adenomyosis by 6 weeks of age rather than at 6 months in untreatedhypertrophic and hyperplastic myometrium (Bird et al. 1972). The pathophysiology of adenomyosis is poorly understood, but risk factors in women include age,