FEATURES OF HEREDITARY, SOMATIC AND REPRODUCTIVE HISTORY IN WOMEN WITH EARLY MENOPAUSE

The article presents the results of studying the hereditary, somatic and reproductive history of women with early depletion of ovarian function with an assessment of their prognostic value.Materials and methods of investigation: 144 women were examined, which were divided into 2 groups. 74 patients had complaints of stopping menstruation before the age of 40 (I, the main group) and 70 women in menopause that occurred after the age of 45 (II, group of comparisons). In all patients by means of a specially developed questionnaire an information about the features of the onset of menopause in mothers and sisters, factors of somatic anamnesis and the state of reproductive health was received. An increase of relative risk was calculated at 95% confidence interval.Results and its discussion. Among the factors of the hereditary history, the greatest increase in the relative risk was found for menopause in the mother or in one of the sisters before the age of 40, which indicates the possibility of inheritance predisposition on the maternal line. For somatic anamnesis factors, an increase in the relative risk of early ovarian malnutrition was not detected. Reproductive health factors were significant for the development of complications - later menarche, combined oral contraceptives, 3or more pregnancy interruptions, and laparoscopic ovarian surgary. Given the possibility of modifying some of these factors, these data should be used when counseling patients.Conclusions:Family history is important for the early depletion of ovarian function - the onset of menopause in a mother up to 40 years increases the risk by 1.8 times, in one of the sisters - by 1.6 times.Later, the menarche raises the risk of ovarian failure by three times, while operative interventions on the ovaries by laparoscopic access are 2.5 times, long-term oral contraceptive intake 1.5 times, and artificial abortion 1.8 times.