Mechanical properties and damage constitutive model of frozen brain tumors under cryogenic-mechanical coupling effect

Mechanical properties and damage constitutive model of frozen brain tumors under cryogenic-mechanical coupling effect | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Article Mechanical properties and damage constitutive model of frozen brain tumors under cryogenic-mechanical coupling effect Wenxuan Hu, Suran Wang, Youliang Chen This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-5346257/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Cryoablation, as an important method for tumor treatment, possesses the advantages of safety, efficiency, and minimally invasive characteristics. However, the phenomenon of intracranial pressure fluctuation caused by brain tumor cryoablation has not received sufficient attention. Investigating the mechanism behind the interaction between intracranial temperature and pressure may contribute to addressing this issue. Considering the coupling effect of temperature and confining pressure, the evolution equation and constitutive model of tumor mechanical damage after freezing were constructed to evaluate the influence of freezing on mechanical properties and damage law of biological tissues in a low temperature environment. Based on the Lemaitre's strain-equivalence principle, the microelement strength of tumor ice body under the coupling of low temperature and confining pressure is assumed to follow a Weibull distribution. The thermal and mechanical damage variables are introduced using continuous damage mechanics and statistical theory, and the microelement failure is in accordance with the SMP criterion. Adopts the numerical simulation of intracranial glioma cryoablation COMSOL temperature - mechanical coupling response mechanism, by numerical simulation and theoretical derivation method to obtain the required constitutive model parameters, the theory of stress-strain curve compared with simulated curve, accord well with those of two kinds of curve. The results show that the established damage statistical constitutive model can accurately reflect the stress-strain characteristics of biological tissues after freezing, and verify the rationality and reliability of the model and its parameter determination method. Physical sciences/Physics/Biological physics Physical sciences/Engineering/Biomedical engineering Cryoablation Stress-strain Solid mechanics Brain glioma Intracranial pressure Constitutive model Full Text Additional Declarations No competing interests reported. Supplementary Files Graphicalabstract.pdf Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-5346257","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Article","associatedPublications":[],"authors":[{"id":382042707,"identity":"19b4768e-a986-4bb6-85a9-ebd44aef9ccd","order_by":0,"name":"Wenxuan Hu","email":"","orcid":"","institution":"University of Shanghai for Science and Technology","correspondingAuthor":false,"prefix":"","firstName":"Wenxuan","middleName":"","lastName":"Hu","suffix":""},{"id":382042708,"identity":"60c2db7d-6763-4727-b5d3-efaa4a51e1ea","order_by":1,"name":"Suran Wang","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAA5klEQVRIiWNgGAWjYFAD9gYo4wDRWnhAShNI0iKRQKQWg+NnD7/82XZP3lzyjfHHnz8Y5PhuJDB+LsCn5UxemjVvW7Hhztk5ZtI8CQzGkjcSmKVn4NFidiDHzJixLYFxw+0cM2agwxI33EhgY+bBp+X8GzPDn20J9htunjH++COBoZ6wlhs5xg942xKAhvMYSAAdlmBASIv9jTdmzDznEpI3nEkrk+ZJkzCceeZhszQ+LZL9OUD3lCXYbjh+ePPHHzY28nzHkw9+xqcFCNgkkDggNmMDfg0MDMwfCKkYBaNgFIyCEQ4AVD5NfZxCQw8AAAAASUVORK5CYII=","orcid":"","institution":"University of Shanghai for Science and Technology","correspondingAuthor":true,"prefix":"","firstName":"Suran","middleName":"","lastName":"Wang","suffix":""},{"id":382042711,"identity":"e7232f32-70fc-4aa0-a81e-14397614719e","order_by":2,"name":"Youliang Chen","email":"","orcid":"","institution":"University of Shanghai for Science and Technology","correspondingAuthor":false,"prefix":"","firstName":"Youliang","middleName":"","lastName":"Chen","suffix":""}],"badges":[],"createdAt":"2024-10-28 10:23:30","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-5346257/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-5346257/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":75859221,"identity":"2bf89bcf-7ef3-4759-b713-6b38ecefc15a","added_by":"auto","created_at":"2025-02-10 04:38:45","extension":"pdf","order_by":1,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":892530,"visible":true,"origin":"","legend":"","description":"","filename":"manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-5346257/v1_covered_47c911cb-6ecc-4510-a7bb-3fa5039e9b46.pdf"},{"id":70278309,"identity":"649b2df7-2777-4150-ad3f-7d528709a695","added_by":"auto","created_at":"2024-12-01 13:19:18","extension":"pdf","order_by":1,"title":"","display":"","copyAsset":false,"role":"supplement","size":757653,"visible":true,"origin":"","legend":"","description":"","filename":"Graphicalabstract.pdf","url":"https://assets-eu.researchsquare.com/files/rs-5346257/v1/613f4f886dd8d38eb1415a30.pdf"}],"financialInterests":"No competing interests reported.","formattedTitle":"Mechanical properties and damage constitutive model of frozen brain tumors under cryogenic-mechanical coupling effect","fulltext":[],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":true,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"Cryoablation, Stress-strain, Solid mechanics, Brain glioma, Intracranial pressure, Constitutive model","lastPublishedDoi":"10.21203/rs.3.rs-5346257/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-5346257/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003eCryoablation, as an important method for tumor treatment, possesses the advantages of safety, efficiency, and minimally invasive characteristics. However, the phenomenon of intracranial pressure fluctuation caused by brain tumor cryoablation has not received sufficient attention. Investigating the mechanism behind the interaction between intracranial temperature and pressure may contribute to addressing this issue. Considering the coupling effect of temperature and confining pressure, the evolution equation and constitutive model of tumor mechanical damage after freezing were constructed to evaluate the influence of freezing on mechanical properties and damage law of biological tissues in a low temperature environment. Based on the Lemaitre's strain-equivalence principle, the microelement strength of tumor ice body under the coupling of low temperature and confining pressure is assumed to follow a Weibull distribution. The thermal and mechanical damage variables are introduced using continuous damage mechanics and statistical theory, and the microelement failure is in accordance with the SMP criterion. Adopts the numerical simulation of intracranial glioma cryoablation COMSOL temperature - mechanical coupling response mechanism, by numerical simulation and theoretical derivation method to obtain the required constitutive model parameters, the theory of stress-strain curve compared with simulated curve, accord well with those of two kinds of curve. The results show that the established damage statistical constitutive model can accurately reflect the stress-strain characteristics of biological tissues after freezing, and verify the rationality and reliability of the model and its parameter determination method.\u003c/p\u003e","manuscriptTitle":"Mechanical properties and damage constitutive model of frozen brain tumors under cryogenic-mechanical coupling effect","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2024-11-29 05:21:46","doi":"10.21203/rs.3.rs-5346257/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"9c663a27-5ddf-4287-b2d5-261bfcc33174","owner":[],"postedDate":"November 29th, 2024","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[{"id":40683960,"name":"Physical sciences/Physics/Biological physics"},{"id":40683961,"name":"Physical sciences/Engineering/Biomedical engineering"}],"tags":[],"updatedAt":"2025-02-10T04:38:08+00:00","versionOfRecord":[],"versionCreatedAt":"2024-11-29 05:21:46","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-5346257","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-5346257","identity":"rs-5346257","version":["v1"]},"buildId":"qtupq5eGEP_6zYnWcrvyt","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}