Investigational and experimental GnRH analogs and associated neurotransmitters

Blumenfeld Z, Zeev Blumenfeld
Expert opinion on investigational drugs · 2017 · vol. 26(6) , pp. 661–667 · doi:10.1080/13543784.2017.1323869 · PMID:28441891 · W2609505714
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⚙ AI-generated summary by claude@2026-06, 2026-06-13 ⓘ

This review summarizes investigational GnRH agonists and discusses their differences from GnRH antagonists, Kisspeptin, and Neurokinin B analogs for various medical conditions.

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Abstract

INTRODUCTION: The GnRH agonistic analogs enable for desensitizing the hypothalamo-pituitary-gonadal axis in malignant and benign conditions where minimizing the production of sex hormones, or blocking ovulation is necessary. The possible indications are prostate cancer, benign prostate hyperplasia, breast cancer, endometriosis, precocious puberty, uterine leiomyomata, assisted reproduction (ART)/in vitro fertilization (IVF), PCOS, minimizing the gonadotoxic effect of chemotherapy in young women, and possibly ovarian cancer. Areas covered: The aim of the current review is to summarize, giving a critical overview, of the investigational GnRH agonists, and shortly discuss the difference between the GnRH agonists, antagonists, Kisspeptin, and Neurokinin B analogs. Expert opinion: The broad armamentarium of agonists may make it possible, in the future, to expand the indications and uses of these analogs, choosing and specifically tailoring the analog to the required effect, while minimizing side effects.

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Condition tags

endometriosis

MeSH descriptors

Drugs, Investigational Gonadotropin-Releasing Hormone Hypothalamo-Hypophyseal System Drugs, Investigational Drugs, Investigational Drugs, Investigational Female Gonadotropin-Releasing Hormone Gonadotropin-Releasing Hormone Gonadotropin-Releasing Hormone Humans Hypothalamo-Hypophyseal System Hypothalamo-Hypophyseal System Kisspeptins Kisspeptins Male Neurokinin B Neurokinin B

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References (42)

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License: CC0 · commercial use OK