The Feasibility of Modified Laparoscopic Female Radical Cystectomy: A Procedural Guide and Comparison with Traditional Technique

The Feasibility of Modified Laparoscopic Female Radical Cystectomy: A Procedural Guide and Comparison with Traditional Technique | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Article The Feasibility of Modified Laparoscopic Female Radical Cystectomy: A Procedural Guide and Comparison with Traditional Technique xin chen, Xiao-Lu Jiang, Jia-Ning Sun, Rui Yang, Feng Zhang, Wei-Cheng Sun, and 2 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-4108248/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Females are generally less likely to develop carcinoma of the urinary bladder compared with melas. Despite radical cystectomy (RC) being an effective surgical technique, its usage in women is limited due to the decreased incidence and potential postoperative complications. We sought to evaluate the safety and feasibility of a novel modified laparoscopic radical cystectomy (MLRC) for female patients with bladder cancer and introduce the modified procedural stepwise. The retrospective cohort study spanned from January 1, 2018, to September 30, 2023, and included 45 female patients who underwent RC. Perioperative data comparison between the MLRC group (25 patients) and the traditional laparoscopic radical cystectomy (TLRC) group (20 patients) was conducted, with differences being deemed significant at P < 0.05. All operations were performed successfully without conversion to open surgery. The MLRC group exhibited less %sCre change (P < 0.001), less estimated blood loss (EBL) (P < 0.001), shorter operative time (P < 0.001), shorter pelvic lymph node dissection (PLND) time (P < 0.001), shorter first postoperative defecation (FPD) time (P < 0.001), and fewer complications (P < 0.05). However, the postoperative hospital stay, urinary reconstruction, overall survival, local recurrence or distant metastasis, and American Society of Anaesthesiology (ASA) score showed no statistical difference. Patients were followed up for 3 to 65 months, with a median of 27 months.MLRC is a safe and feasible procedure that could improve perioperative outcomes compared to traditional procedures. Health sciences/Urology/Bladder Health sciences/Oncology/Surgical oncology bladder cancer laparoscopic radical cystectomy modified female Figures Figure 1 Figure 2 Figure 3 Introduction Bladder cancer is a frequently diagnosed cancer worldwide, with a ranking of 10th place for incidence. The incidence rates are considerably higher in men than in women, with four times higher rates observed in men [ 1 ] . However, female patients are more likely to present with more advanced-stage tumors and have more unfavorable outcomes compared to males [ 2 ] . There is a consensus supported by mainstay guidelines that RC remains the gold standard therapy for high-risk non-muscle-invasive bladder cancer (NMIBC) and muscle-invasive bladder cancer (MIBC) [ 3 – 5 ] . The standard procedure for female RC involves complete removal of the anterior pelvic organs, including the bladder, uterus, fallopian tubes, ovaries, anterior vaginal wall, and urethra [ 6 ] . This surgery has a significant impact on multiple organ systems in female patients. While RC is an effective surgical technique, it is also associated with a high incidence of complications and considerable mortality rates. Previous research has reported a significant incidence of early post-surgery complications following RC, with 64% of patients affected [ 7 ] . In addition, a randomized Phase 3 clinical trial found that the incidence of postoperative adverse events for both robot-assisted and open RC was relatively high, at 67% and 69% respectively [ 8 ] . In this context, modification of surgical procedures may represent a potential factor for the final postoperative outcome. Several studies have identified modifiable factors that can potentially reduce sexual dysfunction after female radical cystectomy [ 9 – 11 ] . However, most of these studies have focused on pelvic organ-preserving RC, leaving a gap in research on the modification of surgical procedures for female RC. Our current study aims to fill this gap by sharing our experience with a modified surgical technique during RC for female patients and providing a stepwise introduction to this approach. Method Patient This retrospective cohort study examined a group of female patients who underwent laparoscopic RC at the Affiliated Yantai Yuhuangding Hospital of Qingdao University between April 2018 and September 2023. The study enrolled 45 consecutive patients, 25 of whom received MLRC and 20 of whom underwent TLRC. All patients underwent standard PLND and completed their procedures without any conversions to open surgery or perioperative deaths. Preoperatively, all patients were diagnosed with malignant bladder tumors and received cystoscopes. Data were collected on demographic characteristics, ASA score, preoperative laboratory results, postoperative laboratory results, EBL, operation time, PLND time, FPD time, postoperative hospital stay, and postoperative complications data. The Clavien-Dindo scale was used to classify the severity of complications [ 12 ] . The anesthesia risk of all patients was evaluated according to ASA score [ 13 ] . The extent of postoperative renal function decline was determined by calculating the maximum change in serum creatinine level as a percentage (%sCre). Postoperative follow-up protocol was performed in accordance with EAU guidelines [ 3 ] . Patients were followed up for 3 to 65 months, with a median of 27 months. The procedure of this study was performed with the approval of the Affiliated Yantai Yuhuangding Hospital of Qingdao University Ethics Committee. All patients were informed that their clinical data might be used in future scientific research and signed the informed consent. Surgical technique Under general anesthesia, the patient is placed in a supine steep Trendelenburg position with the bowel shifted cephalally to expose the pelvic organs fully. A camera port measuring 10mm is inserted 3cm above the umbilicus. Two 12mm trocars are placed on either side of the primary trocar, along the edges of the rectus abdominis. Lastly, two 5mm trocars are placed 3cm medial to the anterior superior iliac spine on both sides. The anteversion of the uterus is achieved by filling sterile gloves with gauze into the vagina. Laparoscopic dissection proceeds with the identification and isolation of the ureters, which can be found at the intersection of the iliac vessels after incising the posterior peritoneum (Fig. 1 A). It is important to mobilize the ureters as close as possible to the bladder but not immediately ligating them. Removing fallopian tubes aims to expose the pelvic organs more clearly. The infundibulopelvic ligament is divided between Hem-o-lok clips (Fig. 1 B). However, if the ovaries need to be preserved, they should be suspended from the pelvic wall. The umbilical artery was secured with Hem-o-lok clips and transected to recognize lateral pelvic space (Fig. 1 C). The lateral uterine ligament was dissected (Fig. 1 D). Dissecting the retro-uterine space, followed by opening the recto-uterine pouch under the junction of the posterior vagina and uterus, sterile gloves with gauze in the vagina can help identify the posterior fornix and prevent disruption of CO2 pneumoperitoneum (Fig. 2 A). To ensure the complete removal of the bladder and anterior vaginal wall, the vaginal incision must pass laterally to the urethra (Fig. 2 B). After the steps above, the Retzius space can be accessed by incising the urachus and medial umbilical ligaments. Then, separate the peritoneum along the bladder's anterior plane to the urethra. After the above dissection was completed, pirarubicin was irrigated into the bladder for 30 minutes to avoid diffusion of cancer cells. A Foley catheter can be used to determine the urethra's position. After transecting the urethra and anterior vaginal wall with an ultrasound knife (Fig. 2 C, D), the uterus is resected en bloc with the bladder. The whole specimen connecting the ureters is then isolated from the pelvic wall. The ureters are connected bilaterally with the whole specimen, which consists of the bladder, uterus, and part of the anterior vagina wall. Hem-o-lok clips are used to ligate the ureters, and the distal ends are incision (Fig. 3 A). Finally, the specimen is put into a large specimen bag and extracted vaginally. Cover the anterior vagina wall's defect with the posterior vagina wall and secure it with absorbable sutures. The extended lymphadenectomy is performed after removing the specimen in vitro, as it allows for complete dissection of the lymph nodes due to more exposed space (Fig. 3 B). Finally, the urinary diversion steps are initiated using the appropriate approach. Statistical analysis The variables were compared between the two groups by student t-test, Mann-Whitney U-test, Pearson’s χ2 test, and Fisher’s exact probabilities according to data scaling. Data were considered statistically significant at p ≤ 0.05 for all tests. Results Table 1 displays the characteristics and perioperative outcomes of our study cohort, consisting of 45 female patients who received laparoscopic radical cystectomy. Of these patients, 25 (56%) underwent MLRC, and 20 (44%) underwent TLRC. Age, body mass index (BMI), postoperative hospital stays, and preoperative serum creatinine measurements did not differ significantly between the two groups. In the MLRC group, 10 (40%) cases received cutaneous ureterostomy (CU), and 15 (60%) cases received ileal conduit (IC). In the TLRC group, 7 (35%) cases received CU, and 13 (65%) cases received IC. No significant difference in the type of urinary diversion was observed between the two groups (P = 0.731). The ASA score exceeded level II in 8 (32%) cases and 7 (35%) cases for the MLRC and TLRC groups, respectively, with no significant difference between the two groups (P = 0.832). The MLRC group had a markedly lower EBL than the TLRC group (109.60 ± 38.24 ml vs. 257.00 ± 39.75 ml; P ＜ 0.001). Patients who underwent MLRC had a mean operation time of 246.20 ± 37.78 min, compared to 314.75 ± 52.28 min for those who underwent TLRC, with a statistically significant difference between the groups (P＜ 0.001). The PLND time was also significantly reduced in the MLRC group, at 23.76 ± 2.77 min compared to 33.75 ± 2.75 min in the TLRC group (P＜ 0.001). In terms of %sCre change, the median (IQR) was 14.8 (12.3) in the MLRC group and 30.1 (17.1) in the TLRC group, with a statistically significant difference between the groups (P＜ 0.001). Based on the Clavien-Dindo scale, it was observed that early complications were experienced by 9 (36%) cases in the MLRC group, while 14 (70%) cases were observed in the TLRC group. Significantly lower early complication rates were noted in the MLRC group (P = 0.023). Among the cases, 2 (8%) severe complications (Clavien grade > 2) were reported in the MLRC group, as compared to 9 (45%) patients with severe complications in the TLRC group. In the original cohort, the median (range) follow-up time was 27 (3–65) months. A total of 5 (20%) patients died in the MLRC group, and 5 (25%) patients died in the TLRC group. The overall survival was 80% in the MLRC group versus 75% in the TLRC group. There were no significant differences in OS (P = 0.688) between the two groups. 6 patients (24%) in the MLRC group and 6 patients (25%) in the TLRC group experienced either local recurrence or distant metastasis, with no significant difference observed across the two groups (P = 0.938). Table 2 displays the postoperative pathological findings of patients from both the MLRC and TLRC groups. The results revealed no significant differences between the two groups. Discussion Although bladder cancer is more prevalent in males than females, female patients tend to present with more advanced-stage tumors and have worse outcomes. Muscle-invasive bladder cancer (MIBC) comprises around 25% of bladder cancer cases and requires costly care while negatively impacting a patient's quality of life [ 14 ] . In cases of localized MIBC and high-risk non-muscle invasive bladder cancer (NMIBC), radical cystectomy (RC) is the preferred and standard therapy, with a five-year overall survival rate of roughly 55% [ 15 ] . Currently, advancements in surgical procedures and technology have led to the replacement of open surgery with minimally invasive options such as laparoscopic and robotic-assisted surgery [ 16 ] . A randomized controlled trial conducted by Khan et al. compared the perioperative outcomes of open RC versus robotic-assisted RC and laparoscopic RC, with the results demonstrating significantly improved outcomes among patients who underwent minimally invasive surgery [ 17 ] . In many developing countries, laparoscopic surgery remains the preferred option due to the comparatively high cost of robotic-assisted procedures, even with the increasing prevalence of robotic surgery [ 18 , 19 ] . The surgical techniques and resection sequences utilized in TLRC and open RC are comparable, involving the removal of the bladder, uterus, fallopian tubes, ovaries, and anterior vagina [ 6 ] . RC is considered an incredibly complex operation with frequent complications and non-negligible high mortality [ 20 – 22 ] . Additionally, studies have shown that females who undergo RC tend to experience longer operation times and higher rates of postoperative complications compared to males [ 23 , 24 ] . To improve perioperative outcomes and the quality of life for female bladder cancer patients, researchers are currently exploring the possibility of pelvic organ-sparing radical cystectomy (POSRC) [ 9 – 11 ] . However, the quality of evidence provided by these studies remains low, and more research is needed to refine patient selection methods [ 25 , 26 ] . To the best of our knowledge, there is currently a lack of surgical procedure modifications for female patients who are not suitable for POSRC. As a solution, we present a step-by-step guide to a new modified laparoscopic RC procedure for females. This innovative approach has the potential to enhance perioperative outcomes. The female pelvic fascia is the loose connective tissue network containing a large amount of vessels and nerves [ 27 ] . The structural alterations of the pelvic fascia have been suggested to be associated with health problems in females [ 28 ] . In our study, significant effort was made to safeguard the pelvic fascia during the modified procedure. As a result, we noted a marked reduction in intraoperative bleeding, a shorter time for the first postoperative bowel movement, and a lower incidence of early complications in the MLRC group. These outcomes demonstrate that protecting the pelvic fascia can help preserve nerves and blood vessels, improve postoperative bowel recovery, and enhance perioperative outcomes. In conventional female RC procedures, an extra surgical assistant would utilize a sponge stick or vaginal manipulator to maintain the uterine position and identify the vaginal apex [ 29 , 30 ] . However, this approach increased medical costs due to the need for more instruments and assistants. To address this issue and reduce costs, we have developed a modified approach that eliminates the need for an additional assistant. By inserting a sterile glove with gauze into the vagina, the uterine position can be maintained, and the vaginal apex can be identified while also preventing CO2 loss. Additionally, our modified technique processes the lateral space after transection of the umbilical artery, cuts the posterior vaginal fornix directly, performs a full-thickness resection bilaterally, and removes the bladder en bloc with the uterus. This modified procedure has significantly shorter operation times. Furrer et al. [ 31 ] conducted an observational cohort study to determine the prevalence of acute kidney injury after RC. Their findings showed that early postoperative AKI occurred in 100 out of 912 patients (11%). The high incidence of AKI is thought to be due to prolonged surgical clamping of the ureter, which hinders urine drainage [ 32 ] . In the patients who underwent MLRC, ureters were not clamped immediately after the ureters were completely dissociated. As results showed previously, the median %sCre change of the MLRC group was significantly lower than that of the TLRC group. This suggests that reducing the duration of ureteral clamping during surgery may help to minimize renal damage caused by the operation. We offer a method for achieving this goal. Removing pelvic lymph nodes is a crucial aspect of RC [ 6 ] . However, there is no agreement on whether to perform lymph node dissection before or after bladder resection. In the MLRC group of our study, all patients received an extended pelvic lymph node dissection following specimen removal. This alteration led to an enhanced surgical field, allowing for more precise operations and faster lymph node dissection. Several limitations exist in the present study. First, the non-randomized patients were collected retrospectively in the present study; the conclusions of this study were negatively affected by an inevitable selection bias. Second, the modified technique has not been widely used, and the surgeons need to have rich experience; MLRC needs to be further standardized. Lastly, the small sample size may decrease the validation of the study. Conclusion This study aims to introduce a reproducible modified laparoscopic female RC. MLRC is a safe and feasible technique that can improve perioperative outcomes with fewer early complications without compromising the oncological outcomes. Female patients who are eligible to receive RC should be considered as candidates for MLRC. Abbreviations RC: Radical cystectomy; MLRC: Modified laparoscopic radical cystectomy; TLRC: Traditional laparoscopic radical cystectomy; EBL: estimated blood loss; PLND: pelvic lymph node dissection; FPD: First postoperative defecation; ASA: American Society of Anaesthesiology; NMIBC: Non–muscle-invasive bladder cancer; MIBC: Muscle-invasive bladder cancer; BMI: body mass index; CU: cutaneous ureterostomy; IC: ileal conduit; Declarations Acknowledgments Not applicable. Authors’ contributions XC, XLJ, JNS, JTW, and HWZ participated in the design and coordination and drafted the manuscript. RY, FZ, and WCS conceived of the study participated in its design and coordination, and helped to edit the manuscript. All authors read and approved the final manuscript. Competing interests The authors declare no competing interests. Availability of data and materials The data that support the findings of this study are available from the corresponding author by email: [email protected] . Ethics approval and consent to participate In studies involving human participants, all procedures were in accordance with the ethical standards of the institutional and/or national research committees and the 1964 Declaration of Helsinki and its later amendments or similar ethical standards. The study was approved by the Yuhuangding Hospital Ethics Committee. All participants signed the informed consent. Consent for publication Informed consent for publication was obtained from all authors. References Sung, H. et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries CA . Cancer J . Clin. 71 , 209-249 (2021). Dobruch, J. et al. Gender and bladder cancer: a collaborative review of etiology, biology, and outcomes. Eur . Urol . 69 , 300-310 (2015). Witjes, J.A. et al. European association of urology guidelines on muscle-invasive and metastatic bladder cancer: summary of the 2020 guidelines. Eur . Urol. 79 , 82-104 (2021). Flaig, T.W. et al. NCCN guidelines® insights: bladder cancer, version 2.2022 J . Natl . Compr . Canc . Netw . 20 , 866-878 (2022). Ghandour, R., Singla, N. & Lotan, Y. Treatment options and outcomes in nonmetastatic muscle invasive bladder cancer. Trends Cancer . 5, 426-43 (2019). Lenis, A.T., Lec, P.M., Chamie, K. & Mshs, M. Bladder cancer: a review. JAMA . 324, 1980-1991 (2020). Shabsigh, A. et al. Defining early morbidity of radical cystectomy for patients with bladder cancer using a standardized reporting methodology. Eur . Urol. 55, 164-174 (2009). Parekh, D.J. et al. Robot-assisted radical cystectomy versus open radical cystectomy in patients with bladder cancer (RAZOR): an open-label, randomised, phase 3, non-inferiority trial. Lancet . 391, 2525-2536 (2018). Lavallée, E. et al. Functional and oncological outcomes of female pelvic organ–preserving robot-assisted radical cystectomy. Eur . Urol . Open Sci. 36, 34-40 (2022). Tuderti, G. et al. Sex-sparing robot-assisted radical cystectomy with intracorporeal padua ileal neobladder in female: surgical technique, perioperative, oncologic and functional outcomes. J . Clin Med . 9, 577 (2020). Zhong, W. et al. Long-term survival after female pelvic organ-sparing radical cystectomy versus standard radical cystectomy: a multi-institutional propensity score-matched analysis. Int. J. Surg . 109, 2742-2750 (2023). Dindo, D., Demartines, N. & Clavien, P.A. Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann . Surg. 240, 205-213 (2004). Li, G., Walco, J.P., Mueller, D.A., Wanderer, J.P. & Freundlich, R.E. Reliability of the ASA physical status classification system in predicting surgical morbidity: a retrospective analysis. J . Med . Syst . 45, 83 (2021). Lobo, N. et al. Epidemiology, screening, and prevention of bladder cancer. Eur . Urol . Oncol. 5, 628-639 (2022). Mitra, A.P. et al. Management trends and outcomes of patients undergoing radical cystectomy for urothelial carcinoma of the bladder: evolution of the university of southern california experience over 3,347 Cases. J . Urol. 207, 302-313 (2022). Wright, J.D. Robotic-assisted surgery: balancing evidence and implementation. JAMA. 318, 1545-1547 (2017). Khan, M.S. et al. A Single-centre early phase randomised controlled three-arm trial of open, robotic, and laparoscopic radical cystectomy (CORAL). Eur Urol. 69, 613-621 (2016). Sundram, M. Asian robotic experience. Urol . Oncol . 28, 677-681 (2010). Ng, A.P. et al. National analysis of cost disparities in robotic-assisted versus laparoscopic abdominal operations. Surgery. 173, 1340-1345 (2023). Kanno, T. et al. Complications and reoperations after laparoscopic radical cystectomy in a Japanese multicenter cohort. Int . J . Urol. 26, 493-498 (2019). Hampson, A., Vincent, A., Dasgupta, P. & Vasdev, N. Radical cystectomy complications and perioperative mortality. BJU . Int . 124, 3-4 (2019). Sobhani, S. et al. Perioperative mortality for radical cystectomy in the modern era: experience from a tertiary referral center. Int . Braz . J . Urol. 49, 351-358 (2023). Siegrist, T., Savage, C., Shabsigh, A., Cronin, A. & Donat, S.M. Analysis of gender differences in early perioperative complications following radical cystectomy at a tertiary cancer center using a standardized reporting methodology Urol . Oncol . 28, 112-117 (2010). Bukavina, L. et al. Gender disparity in cystectomy postoperative outcomes: propensity score analysis of the national surgical quality improvement program database. Eur Urol Oncol. 4, 84-92 (2021). Niver, B.E., Daneshmand, S. & Satkunasivam, R. Female reproductive organ-sparing radical cystectomy: contemporary indications, techniques and outcomes. Curr . Opin . Urol. 25, 105-110 (2015). Veskimäe, E. et al. Systematic review of the oncological and functional outcomes of pelvic organ‐preserving radical cystectomy (RC) compared with standard RC in women who undergo curative surgery and orthotopic neobladder substitution for bladder cancer. BJU . Int . 120, 12-24 (2017). Barber, M.D. Contemporary views on female pelvic anatomy. Cleve . Clin . J . Med . 72 Suppl 4 , S3-11 (2005). Roch, M. et al. The female pelvic floor fascia anatomy: a systematic search and review. Life (Basel) . 11, 900 (2021). Moinzadeh, A. et al. Laparoscopic radical cystectomy in the female. J Urol . 173, 1912-1917 (2005). Chan, K.G. et al. Robot-assisted radical cystectomy and urinary diversion: technical recommendations from the Pasadena Consensus Panel. Eur . Urol. 67, 423-431 (2015). Furrer, M.A., Schneider, M.P., Burkhard, F.C. & Wuethrich, P.Y. Incidence and perioperative risk factors for early acute kidney injury after radical cystectomy and urinary diversion. Urol . Oncol . 36, 306.e17-306.e23 (2018). Ishiyama, Y. et al. Association between ureteral clamping time and acute kidney injury during robot-assisted radical cystectomy. Curr Oncol . 28, 4986-4997 (2021). Tables Additional Declarations No competing interests reported. Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-4108248","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Article","associatedPublications":[],"authors":[{"id":285645798,"identity":"a62de9ea-7fbe-478d-9be0-5f471a80d3c2","order_by":0,"name":"xin chen","email":"","orcid":"","institution":"Affiliated Yantai Yuhuangding Hospital of Qingdao University","correspondingAuthor":false,"prefix":"","firstName":"xin","middleName":"","lastName":"chen","suffix":""},{"id":285645799,"identity":"a757832f-8853-4439-bad1-70c080fde12d","order_by":1,"name":"Xiao-Lu Jiang","email":"","orcid":"","institution":"Affiliated Yantai Yuhuangding Hospital of Qingdao University","correspondingAuthor":false,"prefix":"","firstName":"Xiao-Lu","middleName":"","lastName":"Jiang","suffix":""},{"id":285645800,"identity":"209ccb28-6f3e-4a5e-8b09-1f5d02fb3119","order_by":2,"name":"Jia-Ning Sun","email":"","orcid":"","institution":"Affiliated Hospital of Weifang Medical University, Weifang Medical University","correspondingAuthor":false,"prefix":"","firstName":"Jia-Ning","middleName":"","lastName":"Sun","suffix":""},{"id":285645801,"identity":"5c4fff9b-602f-4978-b217-9d6d25f9163e","order_by":3,"name":"Rui Yang","email":"","orcid":"","institution":"Affiliated Hospital of Weifang Medical University, Weifang Medical University","correspondingAuthor":false,"prefix":"","firstName":"Rui","middleName":"","lastName":"Yang","suffix":""},{"id":285645802,"identity":"f29f2e08-2840-4bf6-bc92-37c4850ddd5a","order_by":4,"name":"Feng Zhang","email":"","orcid":"","institution":"Binzhou Medical University","correspondingAuthor":false,"prefix":"","firstName":"Feng","middleName":"","lastName":"Zhang","suffix":""},{"id":285645803,"identity":"094f992d-7fe8-4b10-91aa-d54ce6fd74d4","order_by":5,"name":"Wei-Cheng Sun","email":"","orcid":"","institution":"Binzhou Medical University","correspondingAuthor":false,"prefix":"","firstName":"Wei-Cheng","middleName":"","lastName":"Sun","suffix":""},{"id":285645804,"identity":"38cea19a-3a70-45c6-a200-65c6c63600b0","order_by":6,"name":"Ji-Tao Wu","email":"","orcid":"","institution":"Affiliated Yantai Yuhuangding Hospital of Qingdao University","correspondingAuthor":false,"prefix":"","firstName":"Ji-Tao","middleName":"","lastName":"Wu","suffix":""},{"id":285645805,"identity":"db6a0347-0442-4be3-baf1-f2a564c45073","order_by":7,"name":"Hong-Wei Zhao","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAA40lEQVRIie3Rr4vDMBTA8UAgM+lqX7jRuulAoap/zCuDqu3YXGWPQSKO8/dnVJ5sN5jKfMWJ1kxf5cGxn3ZH27mJfHS+vLyEEMt6Qswvddv+nTyX0rLGNOpPxkAVFRkNhFYzWZukP/FgpIiT0Tg3ZioatRlwsZc3VYsvFojPOUuRFcTV79idTEotV4Z7Lix2FfJvAmafdyckzgAYXKa8JhXCgUhYDEg4k3FezcMlyu2ABGIFjsLr+iFBHJLwch2AKW6PDFgkvHcXX+um+UmL21e2v8fIc/VHd3KHP3bcsizL+tcZjw5NhuYCESUAAAAASUVORK5CYII=","orcid":"","institution":"Affiliated Yantai Yuhuangding Hospital of Qingdao University","correspondingAuthor":true,"prefix":"","firstName":"Hong-Wei","middleName":"","lastName":"Zhao","suffix":""}],"badges":[],"createdAt":"2024-03-15 13:31:35","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-4108248/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-4108248/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":53954615,"identity":"ea9e4a2b-2041-44c3-a14a-2c88e3b3cf72","added_by":"auto","created_at":"2024-04-02 16:42:49","extension":"jpg","order_by":1,"title":"Figure 1","display":"","copyAsset":false,"role":"figure","size":67238,"visible":true,"origin":"","legend":"\u003cp\u003e\u003cstrong\u003eA \u003c/strong\u003eDissection of the ureter at the intersection of the iliac vessels. \u003cstrong\u003eB \u003c/strong\u003eInfundibulopelvic ligament was cut off. \u003cstrong\u003eC \u003c/strong\u003eTransection of the umbilical artery. \u003cstrong\u003eD \u003c/strong\u003eDissection of the lateral uterine ligament.\u003c/p\u003e","description":"","filename":"1.jpg","url":"https://assets-eu.researchsquare.com/files/rs-4108248/v1/ec29810efffe5cf3e8991b67.jpg"},{"id":53954616,"identity":"d51ca96e-6b1a-465f-bb7f-660f12a0c274","added_by":"auto","created_at":"2024-04-02 16:42:49","extension":"jpg","order_by":2,"title":"Figure 2","display":"","copyAsset":false,"role":"figure","size":74045,"visible":true,"origin":"","legend":"\u003cp\u003e\u003cstrong\u003eA\u003c/strong\u003e, \u003cstrong\u003eBand C \u003c/strong\u003eIncision of the posterior, lateral, and anterior vaginal wall. Sterile gloves with gauze in the vagina help identify the position of the vaginal. \u003cstrong\u003eD \u003c/strong\u003eUsing ultrasound knife to transect urethra.\u003c/p\u003e","description":"","filename":"2.jpg","url":"https://assets-eu.researchsquare.com/files/rs-4108248/v1/a0fd358dba7bf23f7c2d007e.jpg"},{"id":53954617,"identity":"498324ff-6f97-4029-bf00-5db219bda687","added_by":"auto","created_at":"2024-04-02 16:42:50","extension":"jpg","order_by":3,"title":"Figure 3","display":"","copyAsset":false,"role":"figure","size":35731,"visible":true,"origin":"","legend":"\u003cp\u003e\u003cstrong\u003eA \u003c/strong\u003eLigate the ureters and incise the distal end close to the bladder. \u003cstrong\u003eB \u003c/strong\u003ePelvic lymph node dissection was performed.\u003c/p\u003e","description":"","filename":"3.jpg","url":"https://assets-eu.researchsquare.com/files/rs-4108248/v1/0a9df802d5595168efcdf995.jpg"},{"id":58036667,"identity":"dded622e-f57a-4946-bc75-622bbc14060c","added_by":"auto","created_at":"2024-06-10 09:23:40","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":633474,"visible":true,"origin":"","legend":"","description":"","filename":"manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-4108248/v1/f223d802-263b-425e-9af1-4082063eff56.pdf"}],"financialInterests":"No competing interests reported.","formattedTitle":"The Feasibility of Modified Laparoscopic Female Radical Cystectomy: A Procedural Guide and Comparison with Traditional Technique","fulltext":[{"header":"Introduction","content":"\u003cp\u003eBladder cancer is a frequently diagnosed cancer worldwide, with a ranking of 10th place for incidence. The incidence rates are considerably higher in men than in women, with four times higher rates observed in men\u003csup\u003e[\u003cspan citationid=\"CR1\" class=\"CitationRef\"\u003e1\u003c/span\u003e]\u003c/sup\u003e. However, female patients are more likely to present with more advanced-stage tumors and have more unfavorable outcomes compared to males\u003csup\u003e[\u003cspan citationid=\"CR2\" class=\"CitationRef\"\u003e2\u003c/span\u003e]\u003c/sup\u003e. There is a consensus supported by mainstay guidelines that RC remains the gold standard therapy for high-risk non-muscle-invasive bladder cancer (NMIBC) and muscle-invasive bladder cancer (MIBC)\u003csup\u003e[\u003cspan additionalcitationids=\"CR4\" citationid=\"CR3\" class=\"CitationRef\"\u003e3\u003c/span\u003e\u0026ndash;\u003cspan citationid=\"CR5\" class=\"CitationRef\"\u003e5\u003c/span\u003e]\u003c/sup\u003e. The standard procedure for female RC involves complete removal of the anterior pelvic organs, including the bladder, uterus, fallopian tubes, ovaries, anterior vaginal wall, and urethra\u003csup\u003e[\u003cspan citationid=\"CR6\" class=\"CitationRef\"\u003e6\u003c/span\u003e]\u003c/sup\u003e. This surgery has a significant impact on multiple organ systems in female patients. While RC is an effective surgical technique, it is also associated with a high incidence of complications and considerable mortality rates. Previous research has reported a significant incidence of early post-surgery complications following RC, with 64% of patients affected\u003csup\u003e[\u003cspan citationid=\"CR7\" class=\"CitationRef\"\u003e7\u003c/span\u003e]\u003c/sup\u003e. In addition, a randomized Phase 3 clinical trial found that the incidence of postoperative adverse events for both robot-assisted and open RC was relatively high, at 67% and 69% respectively\u003csup\u003e[\u003cspan citationid=\"CR8\" class=\"CitationRef\"\u003e8\u003c/span\u003e]\u003c/sup\u003e. In this context, modification of surgical procedures may represent a potential factor for the final postoperative outcome. Several studies have identified modifiable factors that can potentially reduce sexual dysfunction after female radical cystectomy\u003csup\u003e[\u003cspan additionalcitationids=\"CR10\" citationid=\"CR9\" class=\"CitationRef\"\u003e9\u003c/span\u003e\u0026ndash;\u003cspan citationid=\"CR11\" class=\"CitationRef\"\u003e11\u003c/span\u003e]\u003c/sup\u003e. However, most of these studies have focused on pelvic organ-preserving RC, leaving a gap in research on the modification of surgical procedures for female RC. Our current study aims to fill this gap by sharing our experience with a modified surgical technique during RC for female patients and providing a stepwise introduction to this approach.\u003c/p\u003e"},{"header":"Method","content":"\u003cdiv id=\"Sec3\" class=\"Section2\"\u003e \u003ch2\u003ePatient\u003c/h2\u003e \u003cp\u003eThis retrospective cohort study examined a group of female patients who underwent laparoscopic RC at the Affiliated Yantai Yuhuangding Hospital of Qingdao University between April 2018 and September 2023. The study enrolled 45 consecutive patients, 25 of whom received MLRC and 20 of whom underwent TLRC. All patients underwent standard PLND and completed their procedures without any conversions to open surgery or perioperative deaths. Preoperatively, all patients were diagnosed with malignant bladder tumors and received cystoscopes. Data were collected on demographic characteristics, ASA score, preoperative laboratory results, postoperative laboratory results, EBL, operation time, PLND time, FPD time, postoperative hospital stay, and postoperative complications data. The Clavien-Dindo scale was used to classify the severity of complications\u003csup\u003e[\u003cspan citationid=\"CR12\" class=\"CitationRef\"\u003e12\u003c/span\u003e]\u003c/sup\u003e. The anesthesia risk of all patients was evaluated according to ASA score\u003csup\u003e[\u003cspan citationid=\"CR13\" class=\"CitationRef\"\u003e13\u003c/span\u003e]\u003c/sup\u003e. The extent of postoperative renal function decline was determined by calculating the maximum change in serum creatinine level as a percentage (%sCre). Postoperative follow-up protocol was performed in accordance with EAU guidelines\u003csup\u003e[\u003cspan citationid=\"CR3\" class=\"CitationRef\"\u003e3\u003c/span\u003e]\u003c/sup\u003e. Patients were followed up for 3 to 65 months, with a median of 27 months.\u003c/p\u003e \u003cp\u003e The procedure of this study was performed with the approval of the Affiliated Yantai Yuhuangding Hospital of Qingdao University Ethics Committee. All patients were informed that their clinical data might be used in future scientific research and signed the informed consent.\u003c/p\u003e \u003c/div\u003e \u003cdiv id=\"Sec4\" class=\"Section2\"\u003e \u003ch2\u003eSurgical technique\u003c/h2\u003e \u003cp\u003eUnder general anesthesia, the patient is placed in a supine steep Trendelenburg position with the bowel shifted cephalally to expose the pelvic organs fully. A camera port measuring 10mm is inserted 3cm above the umbilicus. Two 12mm trocars are placed on either side of the primary trocar, along the edges of the rectus abdominis. Lastly, two 5mm trocars are placed 3cm medial to the anterior superior iliac spine on both sides. The anteversion of the uterus is achieved by filling sterile gloves with gauze into the vagina.\u003c/p\u003e \u003cp\u003eLaparoscopic dissection proceeds with the identification and isolation of the ureters, which can be found at the intersection of the iliac vessels after incising the posterior peritoneum (Fig.\u0026nbsp;\u003cspan refid=\"Fig1\" class=\"InternalRef\"\u003e1\u003c/span\u003eA). It is important to mobilize the ureters as close as possible to the bladder but not immediately ligating them. Removing fallopian tubes aims to expose the pelvic organs more clearly. The infundibulopelvic ligament is divided between Hem-o-lok clips (Fig.\u0026nbsp;\u003cspan refid=\"Fig1\" class=\"InternalRef\"\u003e1\u003c/span\u003eB). However, if the ovaries need to be preserved, they should be suspended from the pelvic wall. The umbilical artery was secured with Hem-o-lok clips and transected to recognize lateral pelvic space (Fig.\u0026nbsp;\u003cspan refid=\"Fig1\" class=\"InternalRef\"\u003e1\u003c/span\u003eC). The lateral uterine ligament was dissected (Fig.\u0026nbsp;\u003cspan refid=\"Fig1\" class=\"InternalRef\"\u003e1\u003c/span\u003eD). Dissecting the retro-uterine space, followed by opening the recto-uterine pouch under the junction of the posterior vagina and uterus, sterile gloves with gauze in the vagina can help identify the posterior fornix and prevent disruption of CO2 pneumoperitoneum (Fig.\u0026nbsp;\u003cspan refid=\"Fig2\" class=\"InternalRef\"\u003e2\u003c/span\u003eA). To ensure the complete removal of the bladder and anterior vaginal wall, the vaginal incision must pass laterally to the urethra (Fig.\u0026nbsp;\u003cspan refid=\"Fig2\" class=\"InternalRef\"\u003e2\u003c/span\u003eB). After the steps above, the Retzius space can be accessed by incising the urachus and medial umbilical ligaments. Then, separate the peritoneum along the bladder's anterior plane to the urethra. After the above dissection was completed, pirarubicin was irrigated into the bladder for 30 minutes to avoid diffusion of cancer cells. A Foley catheter can be used to determine the urethra's position. After transecting the urethra and anterior vaginal wall with an ultrasound knife (Fig.\u0026nbsp;\u003cspan refid=\"Fig2\" class=\"InternalRef\"\u003e2\u003c/span\u003eC, D), the uterus is resected en bloc with the bladder. The whole specimen connecting the ureters is then isolated from the pelvic wall. The ureters are connected bilaterally with the whole specimen, which consists of the bladder, uterus, and part of the anterior vagina wall. Hem-o-lok clips are used to ligate the ureters, and the distal ends are incision (Fig.\u0026nbsp;\u003cspan refid=\"Fig3\" class=\"InternalRef\"\u003e3\u003c/span\u003eA). Finally, the specimen is put into a large specimen bag and extracted vaginally. Cover the anterior vagina wall's defect with the posterior vagina wall and secure it with absorbable sutures. The extended lymphadenectomy is performed after removing the specimen in vitro, as it allows for complete dissection of the lymph nodes due to more exposed space (Fig.\u0026nbsp;\u003cspan refid=\"Fig3\" class=\"InternalRef\"\u003e3\u003c/span\u003eB). Finally, the urinary diversion steps are initiated using the appropriate approach.\u003c/p\u003e \u003cp\u003e \u003c/p\u003e \u003cp\u003e \u003c/p\u003e \u003cp\u003e \u003c/p\u003e \u003c/div\u003e \u003cdiv id=\"Sec5\" class=\"Section2\"\u003e \u003ch2\u003eStatistical analysis\u003c/h2\u003e \u003cp\u003eThe variables were compared between the two groups by student t-test, Mann-Whitney U-test, Pearson\u0026rsquo;s χ2 test, and Fisher\u0026rsquo;s exact probabilities according to data scaling. Data were considered statistically significant at p\u0026thinsp;\u0026le;\u0026thinsp;0.05 for all tests.\u003c/p\u003e \u003c/div\u003e"},{"header":"Results","content":"\u003cp\u003eTable 1 displays the characteristics and perioperative outcomes of our study cohort, consisting of 45 female patients who received laparoscopic radical cystectomy. Of these patients, 25 (56%) underwent MLRC, and 20 (44%) underwent TLRC. Age, body mass index (BMI), postoperative hospital stays, and preoperative serum creatinine measurements did not differ significantly between the two groups. In the MLRC group, 10 (40%) cases received cutaneous ureterostomy (CU), and 15 (60%) cases received ileal conduit (IC). In the TLRC group, 7 (35%) cases received CU, and 13 (65%) cases received IC. No significant difference in the type of urinary diversion was observed between the two groups (P = 0.731). The ASA score exceeded level II in 8 (32%) cases and 7 (35%) cases for the MLRC and TLRC groups, respectively, with no significant difference between the two groups (P = 0.832).\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eThe MLRC group had a markedly lower EBL than the TLRC group (109.60 \u0026plusmn; 38.24 ml vs. 257.00 \u0026plusmn; 39.75 ml; P ＜ 0.001). Patients who underwent MLRC had a mean operation time of 246.20 \u0026plusmn; 37.78 min, compared to 314.75 \u0026plusmn; 52.28 min for those who underwent TLRC, with a statistically significant difference between the groups (P＜ 0.001). The PLND time was also significantly reduced in the MLRC group, at 23.76 \u0026plusmn; 2.77 min compared to 33.75 \u0026plusmn; 2.75 min in the TLRC group (P＜ 0.001). In terms of %sCre change, the median (IQR) was 14.8 (12.3) in the MLRC group and 30.1 (17.1) in the TLRC group, with a statistically significant difference between the groups (P＜ 0.001).\u003c/p\u003e\n\u003cp\u003eBased on the Clavien-Dindo scale, it was observed that early complications were experienced by 9 (36%) cases in the MLRC group, while 14 (70%) cases were observed in the TLRC group. Significantly lower early complication rates were noted in the MLRC group (P = 0.023). Among the cases, 2 (8%) severe complications (Clavien grade \u0026gt; 2) were reported in the MLRC group, as compared to 9 (45%) patients with severe complications in the TLRC group.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eIn the original cohort, the median (range) follow-up time was 27 (3\u0026ndash;65) months. A total of 5 (20%) patients died in the MLRC group, and 5 (25%) patients died in the TLRC group. The overall survival was 80% in the MLRC group versus 75% in the TLRC group. There were no significant differences in OS (P = 0.688) between the two groups. 6 patients (24%) in the MLRC group and 6 patients (25%) in the TLRC group experienced either local recurrence or distant metastasis, with no significant difference observed across the two groups (P = 0.938).\u003c/p\u003e\n\u003cp\u003eTable 2 displays the postoperative pathological findings of patients from both the MLRC and TLRC groups. The results revealed no significant differences between the two groups.\u003c/p\u003e"},{"header":"Discussion","content":"\u003cp\u003eAlthough bladder cancer is more prevalent in males than females, female patients tend to present with more advanced-stage tumors and have worse outcomes. Muscle-invasive bladder cancer (MIBC) comprises around 25% of bladder cancer cases and requires costly care while negatively impacting a patient's quality of life\u003csup\u003e[\u003cspan citationid=\"CR14\" class=\"CitationRef\"\u003e14\u003c/span\u003e]\u003c/sup\u003e. In cases of localized MIBC and high-risk non-muscle invasive bladder cancer (NMIBC), radical cystectomy (RC) is the preferred and standard therapy, with a five-year overall survival rate of roughly 55%\u003csup\u003e[\u003cspan citationid=\"CR15\" class=\"CitationRef\"\u003e15\u003c/span\u003e]\u003c/sup\u003e. Currently, advancements in surgical procedures and technology have led to the replacement of open surgery with minimally invasive options such as laparoscopic and robotic-assisted surgery\u003csup\u003e[\u003cspan citationid=\"CR16\" class=\"CitationRef\"\u003e16\u003c/span\u003e]\u003c/sup\u003e. A randomized controlled trial conducted by Khan et al. compared the perioperative outcomes of open RC versus robotic-assisted RC and laparoscopic RC, with the results demonstrating significantly improved outcomes among patients who underwent minimally invasive surgery\u003csup\u003e[\u003cspan citationid=\"CR17\" class=\"CitationRef\"\u003e17\u003c/span\u003e]\u003c/sup\u003e. In many developing countries, laparoscopic surgery remains the preferred option due to the comparatively high cost of robotic-assisted procedures, even with the increasing prevalence of robotic surgery\u003csup\u003e[\u003cspan citationid=\"CR18\" class=\"CitationRef\"\u003e18\u003c/span\u003e, \u003cspan citationid=\"CR19\" class=\"CitationRef\"\u003e19\u003c/span\u003e]\u003c/sup\u003e. The surgical techniques and resection sequences utilized in TLRC and open RC are comparable, involving the removal of the bladder, uterus, fallopian tubes, ovaries, and anterior vagina\u003csup\u003e[\u003cspan citationid=\"CR6\" class=\"CitationRef\"\u003e6\u003c/span\u003e]\u003c/sup\u003e. RC is considered an incredibly complex operation with frequent complications and non-negligible high mortality\u003csup\u003e[\u003cspan additionalcitationids=\"CR21\" citationid=\"CR20\" class=\"CitationRef\"\u003e20\u003c/span\u003e\u0026ndash;\u003cspan citationid=\"CR22\" class=\"CitationRef\"\u003e22\u003c/span\u003e]\u003c/sup\u003e. Additionally, studies have shown that females who undergo RC tend to experience longer operation times and higher rates of postoperative complications compared to males\u003csup\u003e[\u003cspan citationid=\"CR23\" class=\"CitationRef\"\u003e23\u003c/span\u003e, \u003cspan citationid=\"CR24\" class=\"CitationRef\"\u003e24\u003c/span\u003e]\u003c/sup\u003e. To improve perioperative outcomes and the quality of life for female bladder cancer patients, researchers are currently exploring the possibility of pelvic organ-sparing radical cystectomy (POSRC)\u003csup\u003e[\u003cspan additionalcitationids=\"CR10\" citationid=\"CR9\" class=\"CitationRef\"\u003e9\u003c/span\u003e\u0026ndash;\u003cspan citationid=\"CR11\" class=\"CitationRef\"\u003e11\u003c/span\u003e]\u003c/sup\u003e. However, the quality of evidence provided by these studies remains low, and more research is needed to refine patient selection methods\u003csup\u003e[\u003cspan citationid=\"CR25\" class=\"CitationRef\"\u003e25\u003c/span\u003e, \u003cspan citationid=\"CR26\" class=\"CitationRef\"\u003e26\u003c/span\u003e]\u003c/sup\u003e. To the best of our knowledge, there is currently a lack of surgical procedure modifications for female patients who are not suitable for POSRC. As a solution, we present a step-by-step guide to a new modified laparoscopic RC procedure for females. This innovative approach has the potential to enhance perioperative outcomes.\u003c/p\u003e \u003cp\u003eThe female pelvic fascia is the loose connective tissue network containing a large amount of vessels and nerves\u003csup\u003e[\u003cspan citationid=\"CR27\" class=\"CitationRef\"\u003e27\u003c/span\u003e]\u003c/sup\u003e. The structural alterations of the pelvic fascia have been suggested to be associated with health problems in females\u003csup\u003e[\u003cspan citationid=\"CR28\" class=\"CitationRef\"\u003e28\u003c/span\u003e]\u003c/sup\u003e. In our study, significant effort was made to safeguard the pelvic fascia during the modified procedure. As a result, we noted a marked reduction in intraoperative bleeding, a shorter time for the first postoperative bowel movement, and a lower incidence of early complications in the MLRC group. These outcomes demonstrate that protecting the pelvic fascia can help preserve nerves and blood vessels, improve postoperative bowel recovery, and enhance perioperative outcomes. In conventional female RC procedures, an extra surgical assistant would utilize a sponge stick or vaginal manipulator to maintain the uterine position and identify the vaginal apex\u003csup\u003e[\u003cspan citationid=\"CR29\" class=\"CitationRef\"\u003e29\u003c/span\u003e, \u003cspan citationid=\"CR30\" class=\"CitationRef\"\u003e30\u003c/span\u003e]\u003c/sup\u003e. However, this approach increased medical costs due to the need for more instruments and assistants. To address this issue and reduce costs, we have developed a modified approach that eliminates the need for an additional assistant. By inserting a sterile glove with gauze into the vagina, the uterine position can be maintained, and the vaginal apex can be identified while also preventing CO2 loss. Additionally, our modified technique processes the lateral space after transection of the umbilical artery, cuts the posterior vaginal fornix directly, performs a full-thickness resection bilaterally, and removes the bladder en bloc with the uterus. This modified procedure has significantly shorter operation times.\u003c/p\u003e \u003cp\u003eFurrer et al.\u003csup\u003e[\u003cspan citationid=\"CR31\" class=\"CitationRef\"\u003e31\u003c/span\u003e]\u003c/sup\u003econducted an observational cohort study to determine the prevalence of acute kidney injury after RC. Their findings showed that early postoperative AKI occurred in 100 out of 912 patients (11%). The high incidence of AKI is thought to be due to prolonged surgical clamping of the ureter, which hinders urine drainage\u003csup\u003e[\u003cspan citationid=\"CR32\" class=\"CitationRef\"\u003e32\u003c/span\u003e]\u003c/sup\u003e. In the patients who underwent MLRC, ureters were not clamped immediately after the ureters were completely dissociated. As results showed previously, the median %sCre change of the MLRC group was significantly lower than that of the TLRC group. This suggests that reducing the duration of ureteral clamping during surgery may help to minimize renal damage caused by the operation. We offer a method for achieving this goal.\u003c/p\u003e \u003cp\u003eRemoving pelvic lymph nodes is a crucial aspect of RC\u003csup\u003e[\u003cspan citationid=\"CR6\" class=\"CitationRef\"\u003e6\u003c/span\u003e]\u003c/sup\u003e. However, there is no agreement on whether to perform lymph node dissection before or after bladder resection. In the MLRC group of our study, all patients received an extended pelvic lymph node dissection following specimen removal. This alteration led to an enhanced surgical field, allowing for more precise operations and faster lymph node dissection.\u003c/p\u003e \u003cp\u003eSeveral limitations exist in the present study. First, the non-randomized patients were collected retrospectively in the present study; the conclusions of this study were negatively affected by an inevitable selection bias. Second, the modified technique has not been widely used, and the surgeons need to have rich experience; MLRC needs to be further standardized. Lastly, the small sample size may decrease the validation of the study.\u003c/p\u003e"},{"header":"Conclusion","content":"\u003cp\u003eThis study aims to introduce a reproducible modified laparoscopic female RC. MLRC is a safe and feasible technique that can improve perioperative outcomes with fewer early complications without compromising the oncological outcomes. Female patients who are eligible to receive RC should be considered as candidates for MLRC.\u003c/p\u003e"},{"header":"Abbreviations","content":"\u003cp\u003eRC: Radical cystectomy; MLRC: Modified laparoscopic radical cystectomy; TLRC: Traditional laparoscopic radical cystectomy; EBL: estimated blood loss; PLND: pelvic lymph node dissection; FPD: First postoperative defecation; ASA: American Society of Anaesthesiology; NMIBC: Non\u0026ndash;muscle-invasive bladder cancer; MIBC: Muscle-invasive bladder cancer; BMI: body mass index; CU: cutaneous ureterostomy; IC: ileal conduit;\u0026nbsp;\u003c/p\u003e"},{"header":"Declarations","content":"\u003cp\u003e\u003cstrong\u003eAcknowledgments\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eNot applicable.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAuthors’ contributions\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eXC, XLJ, JNS, JTW, and HWZ participated in the design and coordination and drafted the manuscript. RY, FZ, and WCS conceived of the study participated in its design and coordination, and helped to edit the manuscript. All authors read and approved the final manuscript.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eCompeting interests\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe authors declare no competing interests.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAvailability of data and materials\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe data that support the findings of this study are available from the corresponding author by email: [email protected].\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eEthics approval and consent to participate\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eIn studies involving human participants, all procedures were in accordance with the ethical standards of the institutional and/or national research committees and the 1964 Declaration of Helsinki and its later amendments or similar ethical standards. The study was approved by the Yuhuangding Hospital Ethics Committee. All participants signed the informed consent.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eConsent for publication\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eInformed consent for publication was obtained from all authors.\u003c/p\u003e"},{"header":"References","content":"\u003col\u003e\n\u003cli\u003eSung, H. et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries \u003cem\u003eCA\u003c/em\u003e\u003cem\u003e.\u003c/em\u003e\u003cem\u003e Cancer J\u003c/em\u003e\u003cem\u003e.\u003c/em\u003e\u003cem\u003e Clin.\u003c/em\u003e \u003cstrong\u003e71\u003c/strong\u003e\u003cstrong\u003e,\u003c/strong\u003e 209-249 (2021).\u003c/li\u003e\n\u003cli\u003eDobruch, J. et al. Gender and bladder cancer: a collaborative review of etiology, biology, and outcomes. \u003cem\u003eEur\u003c/em\u003e\u003cem\u003e.\u003c/em\u003e\u003cem\u003e Urol\u003c/em\u003e. \u003cstrong\u003e69\u003c/strong\u003e\u003cstrong\u003e,\u003c/strong\u003e 300-310 (2015).\u003c/li\u003e\n\u003cli\u003eWitjes, J.A. et al. European association of urology guidelines on muscle-invasive and metastatic bladder cancer: summary of the 2020 guidelines.\u003cem\u003e Eur\u003c/em\u003e\u003cem\u003e.\u003c/em\u003e\u003cem\u003e Urol.\u003c/em\u003e \u003cstrong\u003e79\u003c/strong\u003e\u003cstrong\u003e,\u003c/strong\u003e 82-104 (2021).\u003c/li\u003e\n\u003cli\u003eFlaig, T.W. et al. NCCN guidelines\u0026reg; insights: bladder cancer, version 2.2022 \u003cem\u003eJ\u003c/em\u003e\u003cem\u003e.\u003c/em\u003e\u003cem\u003e Natl\u003c/em\u003e\u003cem\u003e.\u003c/em\u003e\u003cem\u003e Compr\u003c/em\u003e\u003cem\u003e.\u003c/em\u003e\u003cem\u003e Canc\u003c/em\u003e\u003cem\u003e.\u003c/em\u003e\u003cem\u003e Netw\u003c/em\u003e. \u003cstrong\u003e20\u003c/strong\u003e\u003cstrong\u003e,\u003c/strong\u003e 866-878 (2022).\u003c/li\u003e\n\u003cli\u003eGhandour, R., Singla, N. \u0026amp; Lotan, Y. Treatment options and outcomes in nonmetastatic muscle invasive bladder cancer. \u003cem\u003eTrends Cancer\u003c/em\u003e\u003cem\u003e.\u003c/em\u003e \u003cstrong\u003e5,\u003c/strong\u003e 426-43 (2019).\u003c/li\u003e\n\u003cli\u003eLenis, A.T., Lec, P.M., Chamie, K. \u0026amp; Mshs, M. Bladder cancer: a review. \u003cem\u003eJAMA\u003c/em\u003e. \u003cstrong\u003e324,\u003c/strong\u003e 1980-1991 (2020).\u003c/li\u003e\n\u003cli\u003eShabsigh, A. et al. Defining early morbidity of radical cystectomy for patients with bladder cancer using a standardized reporting methodology. \u003cem\u003eEur\u003c/em\u003e\u003cem\u003e.\u003c/em\u003e\u003cem\u003e Urol.\u003c/em\u003e\u003cem\u003e \u003c/em\u003e\u003cstrong\u003e55,\u003c/strong\u003e 164-174 (2009).\u003c/li\u003e\n\u003cli\u003eParekh, D.J. et al. Robot-assisted radical cystectomy versus open radical cystectomy in patients with bladder cancer (RAZOR): an open-label, randomised, phase 3, non-inferiority trial. \u003cem\u003eLancet\u003c/em\u003e. \u003cstrong\u003e391,\u003c/strong\u003e 2525-2536 (2018).\u003c/li\u003e\n\u003cli\u003eLavall\u0026eacute;e, E. et al. Functional and oncological outcomes of female pelvic organ\u0026ndash;preserving robot-assisted radical cystectomy. \u003cem\u003eEur\u003c/em\u003e\u003cem\u003e.\u003c/em\u003e\u003cem\u003e Urol\u003c/em\u003e\u003cem\u003e.\u003c/em\u003e\u003cem\u003e Open Sci.\u003c/em\u003e \u003cstrong\u003e36,\u003c/strong\u003e 34-40 (2022).\u003c/li\u003e\n\u003cli\u003eTuderti, G. et al. Sex-sparing robot-assisted radical cystectomy with intracorporeal padua ileal neobladder in female: surgical technique, perioperative, oncologic and functional outcomes. \u003cem\u003eJ\u003c/em\u003e\u003cem\u003e.\u003c/em\u003e\u003cem\u003e Clin Med\u003c/em\u003e. \u003cstrong\u003e9,\u003c/strong\u003e 577 (2020).\u003c/li\u003e\n\u003cli\u003eZhong, W. et al. Long-term survival after female pelvic organ-sparing radical cystectomy versus standard radical cystectomy: a multi-institutional propensity score-matched analysis. \u003cem\u003eInt. J. Surg\u003c/em\u003e\u003cem\u003e.\u003c/em\u003e \u003cstrong\u003e109,\u003c/strong\u003e 2742-2750 (2023).\u003c/li\u003e\n\u003cli\u003eDindo, D., Demartines, N. \u0026amp; Clavien, P.A. Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. \u003cem\u003eAnn\u003c/em\u003e\u003cem\u003e.\u003c/em\u003e\u003cem\u003e Surg.\u003c/em\u003e \u003cstrong\u003e240, \u003c/strong\u003e205-213 (2004).\u003c/li\u003e\n\u003cli\u003eLi, G., Walco, J.P., Mueller, D.A., Wanderer, J.P. \u0026amp; Freundlich, R.E. Reliability of the ASA physical status classification system in predicting surgical morbidity: a retrospective analysis. \u003cem\u003eJ\u003c/em\u003e\u003cem\u003e.\u003c/em\u003e\u003cem\u003e Med\u003c/em\u003e\u003cem\u003e.\u003c/em\u003e\u003cem\u003e Syst\u003c/em\u003e. \u003cstrong\u003e45,\u003c/strong\u003e 83 (2021).\u003c/li\u003e\n\u003cli\u003eLobo, N. et al. Epidemiology, screening, and prevention of bladder cancer. \u003cem\u003eEur\u003c/em\u003e\u003cem\u003e.\u003c/em\u003e\u003cem\u003e Urol\u003c/em\u003e\u003cem\u003e.\u003c/em\u003e\u003cem\u003e Oncol.\u003c/em\u003e\u003cem\u003e \u003c/em\u003e\u003cstrong\u003e5,\u003c/strong\u003e 628-639 (2022).\u003c/li\u003e\n\u003cli\u003eMitra, A.P. et al. Management trends and outcomes of patients undergoing radical cystectomy for urothelial carcinoma of the bladder: evolution of the university of southern california experience over 3,347 Cases. \u003cem\u003eJ\u003c/em\u003e\u003cem\u003e.\u003c/em\u003e\u003cem\u003e Urol.\u003c/em\u003e \u003cstrong\u003e207,\u003c/strong\u003e 302-313 (2022).\u003c/li\u003e\n\u003cli\u003eWright, J.D. Robotic-assisted surgery: balancing evidence and implementation. \u003cem\u003eJAMA.\u003c/em\u003e \u003cstrong\u003e318,\u003c/strong\u003e 1545-1547 (2017).\u003c/li\u003e\n\u003cli\u003eKhan, M.S. et al. A Single-centre early phase randomised controlled three-arm trial of open, robotic, and laparoscopic radical cystectomy (CORAL). \u003cem\u003eEur Urol.\u003c/em\u003e \u003cstrong\u003e69,\u003c/strong\u003e 613-621 (2016). \u003c/li\u003e\n\u003cli\u003eSundram, M. Asian robotic experience. \u003cem\u003eUrol\u003c/em\u003e\u003cem\u003e.\u003c/em\u003e\u003cem\u003e Oncol\u003c/em\u003e\u003cem\u003e. \u003c/em\u003e\u003cstrong\u003e28,\u003c/strong\u003e 677-681 (2010).\u003c/li\u003e\n\u003cli\u003eNg, A.P. et al. National analysis of cost disparities in robotic-assisted versus laparoscopic abdominal operations. \u003cem\u003eSurgery.\u003c/em\u003e \u003cstrong\u003e173,\u003c/strong\u003e 1340-1345 (2023).\u003c/li\u003e\n\u003cli\u003eKanno, T. et al. Complications and reoperations after laparoscopic radical cystectomy in a Japanese multicenter cohort. \u003cem\u003eInt\u003c/em\u003e\u003cem\u003e.\u003c/em\u003e\u003cem\u003e J\u003c/em\u003e\u003cem\u003e.\u003c/em\u003e\u003cem\u003e Urol.\u003c/em\u003e \u003cstrong\u003e26,\u003c/strong\u003e 493-498 (2019).\u003c/li\u003e\n\u003cli\u003eHampson, A., Vincent, A., Dasgupta, P. \u0026amp; Vasdev, N. Radical cystectomy complications and perioperative mortality. \u003cem\u003eBJU\u003c/em\u003e\u003cem\u003e.\u003c/em\u003e\u003cem\u003e Int\u003c/em\u003e. \u003cstrong\u003e124,\u003c/strong\u003e 3-4 (2019).\u003c/li\u003e\n\u003cli\u003eSobhani, S. et al. Perioperative mortality for radical cystectomy in the modern era: experience from a tertiary referral center. \u003cem\u003eInt\u003c/em\u003e\u003cem\u003e.\u003c/em\u003e\u003cem\u003e Braz\u003c/em\u003e\u003cem\u003e.\u003c/em\u003e\u003cem\u003e J\u003c/em\u003e\u003cem\u003e.\u003c/em\u003e\u003cem\u003e Urol.\u003c/em\u003e\u003cem\u003e \u003c/em\u003e\u003cstrong\u003e49,\u003c/strong\u003e 351-358 (2023).\u003c/li\u003e\n\u003cli\u003eSiegrist, T., Savage, C., Shabsigh, A., Cronin, A. \u0026amp; Donat, S.M. Analysis of gender differences in early perioperative complications following radical cystectomy at a tertiary cancer center using a standardized reporting methodology \u003cem\u003eUrol\u003c/em\u003e\u003cem\u003e.\u003c/em\u003e\u003cem\u003e Oncol\u003c/em\u003e\u003cem\u003e. \u003c/em\u003e\u003cstrong\u003e28,\u003c/strong\u003e 112-117 (2010).\u003c/li\u003e\n\u003cli\u003eBukavina, L. et al. Gender disparity in cystectomy postoperative outcomes: propensity score analysis of the national surgical quality improvement program database. \u003cem\u003eEur Urol Oncol.\u003c/em\u003e \u003cstrong\u003e4, \u003c/strong\u003e84-92 (2021).\u003c/li\u003e\n\u003cli\u003eNiver, B.E., Daneshmand, S. \u0026amp; Satkunasivam, R. Female reproductive organ-sparing radical cystectomy: contemporary indications, techniques and outcomes. \u003cem\u003eCurr\u003c/em\u003e\u003cem\u003e.\u003c/em\u003e\u003cem\u003e Opin\u003c/em\u003e\u003cem\u003e.\u003c/em\u003e\u003cem\u003e Urol.\u003c/em\u003e \u003cstrong\u003e25,\u003c/strong\u003e 105-110 (2015).\u003c/li\u003e\n\u003cli\u003eVeskim\u0026auml;e, E. et al. Systematic review of the oncological and functional outcomes of pelvic organ‐preserving radical cystectomy (RC) compared with standard RC in women who undergo curative surgery and orthotopic neobladder substitution for bladder cancer. \u003cem\u003eBJU\u003c/em\u003e\u003cem\u003e.\u003c/em\u003e\u003cem\u003e Int\u003c/em\u003e. \u003cstrong\u003e120,\u003c/strong\u003e 12-24 (2017).\u003c/li\u003e\n\u003cli\u003eBarber, M.D. Contemporary views on female pelvic anatomy. \u003cem\u003eCleve\u003c/em\u003e\u003cem\u003e.\u003c/em\u003e\u003cem\u003e Clin\u003c/em\u003e\u003cem\u003e.\u003c/em\u003e\u003cem\u003e J\u003c/em\u003e\u003cem\u003e.\u003c/em\u003e\u003cem\u003e Med\u003c/em\u003e. \u003cstrong\u003e72 Suppl 4\u003c/strong\u003e\u003cstrong\u003e,\u003c/strong\u003e S3-11 (2005).\u003c/li\u003e\n\u003cli\u003eRoch, M. et al. The female pelvic floor fascia anatomy: a systematic search and review. \u003cem\u003eLife (Basel)\u003c/em\u003e. \u003cstrong\u003e11,\u003c/strong\u003e 900 (2021).\u003c/li\u003e\n\u003cli\u003eMoinzadeh, A. et al. Laparoscopic radical cystectomy in the female. \u003cem\u003eJ Urol\u003c/em\u003e. \u003cstrong\u003e173,\u003c/strong\u003e 1912-1917 (2005).\u003c/li\u003e\n\u003cli\u003eChan, K.G. et al. Robot-assisted radical cystectomy and urinary diversion: technical recommendations from the Pasadena Consensus Panel. \u003cem\u003eEur\u003c/em\u003e\u003cem\u003e.\u003c/em\u003e\u003cem\u003e Urol.\u003c/em\u003e \u003cstrong\u003e67,\u003c/strong\u003e 423-431 (2015). \u003c/li\u003e\n\u003cli\u003eFurrer, M.A., Schneider, M.P., Burkhard, F.C. \u0026amp; Wuethrich, P.Y. Incidence and perioperative risk factors for early acute kidney injury after radical cystectomy and urinary diversion. \u003cem\u003eUrol\u003c/em\u003e\u003cem\u003e.\u003c/em\u003e\u003cem\u003e Oncol\u003c/em\u003e. \u003cstrong\u003e36,\u003c/strong\u003e 306.e17-306.e23 (2018).\u003c/li\u003e\n\u003cli\u003eIshiyama, Y. et al. Association between ureteral clamping time and acute kidney injury during robot-assisted radical cystectomy. \u003cem\u003eCurr Oncol\u003c/em\u003e. 28, 4986-4997 (2021).\u003c/li\u003e\n\u003c/ol\u003e"},{"header":"Tables","content":"\u003cp\u003e\u003cimg src=\"data:image/png;base64,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\" width=\"664\" height=\"682\"\u003e\u003c/p\u003e\n\u003cp\u003e\u003cimg src=\"data:image/png;base64,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\" width=\"659\" height=\"504\"\u003e\u003c/p\u003e"}],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":true,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":false,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":false,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"bladder cancer, laparoscopic radical cystectomy, modified, female","lastPublishedDoi":"10.21203/rs.3.rs-4108248/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-4108248/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003eFemales are generally less likely to develop carcinoma of the urinary bladder compared with melas. Despite radical cystectomy (RC) being an effective surgical technique, its usage in women is limited due to the decreased incidence and potential postoperative complications. We sought to evaluate the safety and feasibility of a novel modified laparoscopic radical cystectomy (MLRC) for female patients with bladder cancer and introduce the modified procedural stepwise. The retrospective cohort study spanned from January 1, 2018, to September 30, 2023, and included 45 female patients who underwent RC. Perioperative data comparison between the MLRC group (25 patients) and the traditional laparoscopic radical cystectomy (TLRC) group (20 patients) was conducted, with differences being deemed significant at P\u0026thinsp;\u0026lt;\u0026thinsp;0.05. All operations were performed successfully without conversion to open surgery. The MLRC group exhibited less %sCre change (P\u0026thinsp;\u0026lt;\u0026thinsp;0.001), less estimated blood loss (EBL) (P\u0026thinsp;\u0026lt;\u0026thinsp;0.001), shorter operative time (P\u0026thinsp;\u0026lt;\u0026thinsp;0.001), shorter pelvic lymph node dissection (PLND) time (P\u0026thinsp;\u0026lt;\u0026thinsp;0.001), shorter first postoperative defecation (FPD) time (P\u0026thinsp;\u0026lt;\u0026thinsp;0.001), and fewer complications (P\u0026thinsp;\u0026lt;\u0026thinsp;0.05). However, the postoperative hospital stay, urinary reconstruction, overall survival, local recurrence or distant metastasis, and American Society of Anaesthesiology (ASA) score showed no statistical difference. Patients were followed up for 3 to 65 months, with a median of 27 months.MLRC is a safe and feasible procedure that could improve perioperative outcomes compared to traditional procedures.\u003c/p\u003e","manuscriptTitle":"The Feasibility of Modified Laparoscopic Female Radical Cystectomy: A Procedural Guide and Comparison with Traditional Technique","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2024-04-02 16:42:45","doi":"10.21203/rs.3.rs-4108248/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"55866b6c-f8be-44df-b7a9-8940388e0343","owner":[],"postedDate":"April 2nd, 2024","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[{"id":30070734,"name":"Health sciences/Urology/Bladder"},{"id":30070735,"name":"Health sciences/Oncology/Surgical oncology"}],"tags":[],"updatedAt":"2024-06-10T09:15:34+00:00","versionOfRecord":[],"versionCreatedAt":"2024-04-02 16:42:45","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-4108248","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-4108248","identity":"rs-4108248","version":["v1"]},"buildId":"qtupq5eGEP_6zYnWcrvyt","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}