Effect of mifepristone on the expression of COX-2 in rat eutopic and ectopic endometrium

Aim: To explore the effect of mifepristone on the expression of COX-2 in rat eutopic and ectopic endometrium.Methods:Endometriotic rats were randomly divided into control group and mifepristone group(including low dose and high dose groups).4 weeks after gastrogavage with tuwen-80 only(control group) or tuwen-80 plus mifepristone 0.62 mg/d(low dose group) or 1.24 mg/d(high dose group),all rats were killed and tissues of ectopic and eutopic endometrium were removed for detecting COX-2 expression via immunohistochemistry(S-P method). Results:1) In the eutopic endometrium,the expression intensity of COX-2 in the high dose group was lower than that in the low dose group and the control group(P0.01).The expression intensity of COX-2 in the low dose group was lower than that in the control group(P0.01).2) In the ectopic endometrium,the expression intensity of COX-2 in the high dose group was lower than that in the low dose group(P0.01)and the control group(P0.01),but it was no markedly difference between the low dose group and the control group.3)In both high dose and low dose groups,the expression intensity of COX-2 in the ectopic endometrium was higher than that in the eutopic endometrium (P0.01),but in the control group,it was no significantly difference in the expression intensity of COX-2 between the ectopic endometrium and the eutopic endometrium.Conclusion:The treament effect of mifepristone on EMS might be related with decreased expression of COX-2.