The Expressions of Matrix Metalloproteinase-9 and Tissue Inhibitors of Metalloproteinase-1 in Scar Endometriosis and Full Term Endometrium.

Objective : Endometriosis in a surgical scar following cesarian section is rare condition. And its pathogenesis has not been well established, The purpose of this study is to observe the expressions of matrix metalloproteinase-9 (MMP-9) and tissue inhibitors of metalloproteinase-I (TIMP-1) in scar endometriosis and full term endometrium during cesarian section. Methods: Nineteen scar endometriotic tissue and ten full term pregnant endometrium during cesarian section were investigated by immunohistochemical stain for MMP-9 and T1MP-1. Results: The MMP-9 was expressed in eleven of nineteen scar endometriotic tissue (57.9%) and eight of ten full term pregnant endometrium (80.0%). The T1MP-1 was not expressed in both scar endometriotic tissue and full term pregnant endometrium. Conclusion : These results suggest that the relationship between MMP-9 and T1MP-1 might play a role of pathogenesis of scar endometriosis.