[Endometriosis: gynecological diagnosis and treatment : What should pain management specialists know?]

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This S2k guideline provides recommendations for the diagnosis and treatment of endometriosis, emphasizing interdisciplinary cooperation for patient care.

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This paper provides an overview of the main recommendations from Germany’s AWMF S2k guideline “Diagnostics and therapy of endometriosis,” developed using a systematic PubMed and Cochrane literature search (2014–2018) and assessed by multidisciplinary stakeholders including patient groups. The authors report that a structured consensus process produced 48 recommendations and 27 statements, with key emphasis placed on interprofessional, cross-sector interdisciplinary cooperation for patients with suspected or confirmed disease. A major caveat is that the paper is an extracted presentation of guideline content rather than an original study. This paper is centrally about endometriosis — it summarizes the S2k guideline’s diagnostic and treatment recommendations and highlights interdisciplinary care for (suspected) endometriosis.

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Abstract

BACKGROUND: Endometriosis is one of the most common diseases in women of reproductive age. Despite characteristic symptoms such as dysmenorrhea, chronic abdominal pain, dysuria, dyschezia and dyspareunia, the average latency until diagnosis is around 10 years. In addition to the individual limitations, the disease also has economic and health policy relevance. The complaints are followed by reductions in working hours, cyclically recurring short-term sick leave or presenteeism with reduced performance. OBJECTIVE: An overview of the main recommendations of the S2k guideline on the diagnosis and treatment of endometriosis. MATERIAL AND METHODS: For the S2k guideline "Diagnostics and therapy of endometriosis", a systematic literature search was conducted in PubMed and Cochrane according to a defined algorithm and over a period of more than 5 years, from 01.01.2014 to 31.12.2018. For the evaluation, 322 publications, including systematic reviews, meta-analyses and randomized controlled trials were considered and these were assessed by 41 mandate holders and representatives from 25 Association of the Scientific Medical Societies in Germany (AWMF) and non-AWMF professional societies, organizations, associations and working groups of the German Society for Gynecology and Obstetrics (DGGG), as well as two patient target groups. RESULTS: In a structured consensus process, 48 recommendations and 27 statements were formulated, which are presented in extracts in this paper. DISCUSSION: Interdisciplinary cooperation is essential in the treatment of patients with (suspected) endometriosis. This team should include all necessary disciplines in a cross-sectoral network. This is most likely to be achieved in a certified structure.
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Material

und Methoden Für die S2k-Leitlinie „Diagnostik und Therapie der Endometriose“ der Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften (AWMF; Registernummer 015/045) wurde eine systematisierte Literaturrecherche in PubMed und Cochrane nach einem definierten Algorithmus und über einen Zeitraum von 5 Jahren, vom 01.01.2014 bis 31.12.2018, durchgeführt. Für die Auswertung wurden 322 Publikationen, unter anderem systematische Reviews, Metaanalysen und randomisierte, kontrollierte Studien, berücksichtigt und von 41 Mandatsträgern und Stellvertretern aus 25 AWMF- und Nicht-AWMF-Fachgesellschaften, Organisationen, Vereinen und Arbeitsgemeinschaften der DGGG sowie von zwei Patientenzielgruppen beurteilt. Ergebnisse In einem strukturierten Konsensusprozess wurden 48 Empfehlungen und 27 Statements formuliert, die in der vorliegenden Arbeit auszugsweise vorgestellt werden sollen. Schlussfolgerung Wesentlich in der Behandlung von Patientinnen mit (Verdacht auf) Endometriose ist die interdisziplinäre Zusammenarbeit. Das interdisziplinäre Team sollte im sektorenübergreifenden Netzwerk alle notwendigen Disziplinen beinhalten. Dies ist am ehesten in einer zertifizierten Struktur realisierbar.

Abstract

Background Endometriosis is one of the most common diseases in women of reproductive age. Despite characteristic symptoms such as dysmenorrhea, chronic abdominal pain, dysuria, dyschezia and dyspareunia, the average latency until diagnosis is around 10 years. In addition to the individual limitations, the disease also has economic and health policy relevance. The complaints are followed by reductions in working hours, cyclically recurring short-term sick leave or presenteeism with reduced performance.

Objective

An overview of the main recommendations of the S2k guideline on the diagnosis and treatment of endometriosis.

Material and methods

For the S2k guideline “Diagnostics and therapy of endometriosis”, a systematic literature search was conducted in PubMed and Cochrane according to a defined algorithm and over a period of more than 5 years, from 01.01.2014 to 31.12.2018. For the evaluation, 322 publications, including systematic reviews, meta-analyses and randomized controlled trials were considered and these were assessed by 41 mandate holders and representatives from 25 Association of the Scientific Medical Societies in Germany (AWMF) and non-AWMF professional societies, organizations, associations and working groups of the German Society for Gynecology and Obstetrics (DGGG), as well as two patient target groups.

Results

In a structured consensus process, 48 recommendations and 27 statements were formulated, which are presented in extracts in this paper.

Discussion

Interdisciplinary cooperation is essential in the treatment of patients with (suspected) endometriosis. This team should include all necessary disciplines in a cross-sectoral network. This is most likely to be achieved in a certified structure. Similar content being viewed by others Literatur Burghaus S et al (2019) Standards used by a clinical and scientific endometriosis center for the diagnosis and therapy of patients with endometriosis. Geburtshilfe Frauenheilkd 79(5):487–497 Diagnosis and therapy of endometriosis. Guideline of the DGGG, SGGG and OEGGG (S2k-Level, AWMF Registry No. 045/015, Mai 2020). http://www.awmf.org/leitlinien/detail/ll/015-045.html. Zugegriffen: 9. Dez. 2020 Koninckx PR, Martin DC (1992) Deep endometriosis: a consequence of infiltration or retraction or possibly adenomyosis externa? 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Fertil Steril 110(1):137–152.e1 Muzii L et al (2016) Continuous versus cyclic oral contraceptives after laparoscopic excision of ovarian endometriomas: a systematic review and metaanalysis. Am J Obstet Gynecol 214(2):203–211 Grandi G et al (2015) Pelvic pain and quality of life of women with endometriosis during quadriphasic estradiol valerate/dienogest oral contraceptive: a patient-preference prospective 24-week pilot study. Reprod Sci 22(5):626–632 Hormonal Contraception. Guideline of the DGGG, SGGG and OEGGG (S 3‑Level , AW MF Registry No. 015/015 , November 2019). http://www.awmf.org/leitlinien/detail/II/015-015.html. Zugegriffen: 9. Dez. 2020 Gallo MF et al (2014) Combination contraceptives: effects on weight. Cochrane Database Syst Rev. https://doi.org/10.1002/14651858.CD003987.pub5 Ferrero S, Barra F, Leone Roberti Maggiore U (2018) Current and emerging therapeutics for the management of endometriosis. Drugs p:1–18 Li Q et al (2018) Drug therapy for adenomyosis: a prospective, nonrandomized, parallel-controlled study. J Int Med Res 46(5):1855–1865 Nagandla K et al (2014) Hormonal treatment for uterine adenomyosis. Cochrane Database Syst Rev. https://doi.org/10.1002/14651858.CD011372 de Resende JAJ et al (2017) Risk of urinary retention after nerve-sparing surgery for deep infiltrating endometriosis: a systematic review and meta-analysis. Neurourol Urodyn 36(1):57–61 Riley KA et al (2018) Surgical excision versus ablation for superficial endometriosis-associated pain: a randomized controlled trial. J Minim Invasive Gynecol 26(1):71–77 Mechsner S (2021) Endometrioseschmerz beherrschen. Stufenschema und klinische Erfahrungen. Schmerz. https://doi.org/10.1007/s00482-021-00543-8 Hudelist G et al (2012) Diagnostic delay for endometriosis in Austria and Germany: causes and possible consequences. Hum Reprod 27(12):3412–3416 Soliman AM et al (2016) The direct and indirect costs associated with endometriosis: a systematic literature review. Hum Reprod 31(4):712–722 Author information Authors and Affiliations Corresponding author Ethics declarations Interessenkonflikt S. Burghaus und M.W. Beckmann geben an, dass kein Interessenkonflikt besteht. Für diesen Beitrag wurden von den Autorinnen keine Studien an Menschen oder Tieren durchgeführt. Für die aufgeführten Studien gelten die jeweils dort angegebenen ethischen Richtlinien. Rights and permissions About this article Cite this article Burghaus, S., Beckmann, M.W. Endometriose – gynäkologische Diagnostik und Therapie. Schmerz 35, 172–178 (2021). https://doi.org/10.1007/s00482-021-00541-w Received: Revised: Accepted: Published: Version of record: Issue date: DOI: https://doi.org/10.1007/s00482-021-00541-w Schlüsselwörter - Klassifikation der Endometriose - Gestagene - Laparoskopie - Transvaginale Sonographie - Interdisziplinäres Versorgungsteam

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Condition tags

mesh:D004715endometriosisdysmenorrheadyspareunia

MeSH descriptors

Endometriosis Endometriosis Endometriosis Gynecology Female Germany Humans Pain Management Pregnancy Specialization

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